A Mechanistic Study on the Fluidization and Enhancement Effects of Cineole Toward Stratum Corneum Intercellular Lamellar Lipids: A Liquid Crystalline Model Approach

• Published in: Iranian journal of pharmaceutical research : IJPR Vol. 22; no. 1; p. e134731
• Main Authors: Karami, Leila, Moghimi, Hamid Reza
• Format: Journal Article
• Language: English
• Published: Netherlands Brieflands 01.12.2023
• Subjects: Skin Permeation Enhancers; 1,8-Cineole; Transdermal Drug Delivery; Lamellar Liquid Crystals; Model Stratum Corneum Lipids

Background: The stratum corneum (SC) serves as the primary barrier for permeation in human skin. Penetration enhancers, such as 1,8-cineole, are utilized to enhance the permeation of drugs. Cineole increases the permeation of chemicals through different mechanisms. However, its mechanism, particular...