Conditionally replicative adenovirus as a therapy for malignant peripheral nerve sheath tumors

• Published in: Molecular therapy. Oncology Vol. 32; no. 2; p. 200783
• Main Authors: Nikrad, Julia A, Galvin, Robert T, Sheehy, Mackenzie M, Novacek, Ethan L, Jacobsen, Kari L, Corbière, Stanislas M A S, Beckmann, Pauline J, Jubenville, Tyler A, Yamamoto, Masato, Largaespada, David A
• Format: Journal Article
• Language: English
• Published: United States 20.06.2024
• Subjects: cyclooxygenase 2 (COX2); oncolytic adenovirus; conditionally replicative adenovirus (CRAd); neurofibromatosis type 1 (NF1); MT: Regular Issue; malignant peripheral nerve sheath tumor (MPNST)

Oncolytic adenoviruses (Ads) stand out as a promising strategy for the targeted infection and lysis of tumor cells, with well-established clinical utility across various malignancies. This study delves into the therapeutic potential of oncolytic Ads in the context of neurofibromatosis type 1 (NF1)-a...