SECRETION OF IL-6, IL-11 AND LIF BY HUMAN CARDIOMYOCYTES IN PRIMARY CULTURE
Interleukin (IL)-6-type cytokines are multifunctional proteins involved in cardiac hypertrophy and myocardial protection. Recent studies, performed on animal models, report the production of these cytokines by heart. The aim of this study was to analyse the capacity of myocytes and fibroblasts isola...
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Published in | Cytokine (Philadelphia, Pa.) Vol. 18; no. 4; pp. 199 - 205 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
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England
Elsevier Ltd
21.05.2002
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Abstract | Interleukin (IL)-6-type cytokines are multifunctional proteins involved in cardiac hypertrophy and myocardial protection. Recent studies, performed on animal models, report the production of these cytokines by heart. The aim of this study was to analyse the capacity of myocytes and fibroblasts isolated from human atrium to secrete IL-6, leukaemia inhibitory factor (LIF), cardiotrophin-1 (CT-1), IL-11, oncostatin M (OSM), ciliary neurotrophic factor (CNTF) and the soluble receptor subunits sIL-6R and sgp130 during primary culture. We detected LIF, IL-11, sgp130 and a large amount of IL-6, but not OSM, CT-1, CNTF nor IL-6R in these culture supernatants. Both cardiomyocytes and fibroblasts are able to spontaneously produce IL-6. The increase of IL-6 production all along the culture period appears to be the consequence of fibroblast proliferation and gp130 stimulation. This is the first demonstration that human cardiac cells are able to secrete IL-6, but also LIF and IL-11 in vitro. These cytokines could be involved in an autocrine and/or a paracrine networks regulating myocardial cyto-protection, hypertrophy and fibrosis. |
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AbstractList | Interleukin (IL)-6-type cytokines are multifunctional proteins involved in cardiac hypertrophy and myocardial protection. Recent studies, performed on animal models, report the production of these cytokines by heart. The aim of this study was to analyse the capacity of myocytes and fibroblasts isolated from human atrium to secrete IL-6, leukaemia inhibitory factor (LIF), cardiotrophin-1 (CT-1), IL-11, oncostatin M (OSM), ciliary neurotrophic factor (CNTF) and the soluble receptor subunits sIL-6R and sgp130 during primary culture. We detected LIF, IL-11, sgp130 and a large amount of IL-6, but not OSM, CT-1, CNTF nor IL-6R in these culture supernatants. Both cardiomyocytes and fibroblasts are able to spontaneously produce IL-6. The increase of IL-6 production all along the culture period appears to be the consequence of fibroblast proliferation and gp130 stimulation. This is the first demonstration that human cardiac cells are able to secrete IL-6, but also LIF and IL-11 in vitro. These cytokines could be involved in an autocrine and/or a paracrine networks regulating myocardial cyto-protection, hypertrophy and fibrosis. |
Author | Wijdenes, John Froger, Josy Ancey, Cecile Delwail, Adriana Potreau, Daniel Corbi, Pierre Lecron, Jean-Claude Gascan, Hugues |
Author_xml | – sequence: 1 givenname: Cecile surname: Ancey fullname: Ancey, Cecile organization: Laboratoire des Biomembranes et Signalisation Cellulaire, UMR CNRS 6558, Université de Poitiers, France – sequence: 2 givenname: Pierre surname: Corbi fullname: Corbi, Pierre organization: Unité de Chirurgie Cardio-thoracique, Centre Hospitalier Universitaire, Poitiers, France – sequence: 3 givenname: Josy surname: Froger fullname: Froger, Josy organization: INSERM EMI 9928, Centre Hospitalier Universitaire, Angers, France – sequence: 4 givenname: Adriana surname: Delwail fullname: Delwail, Adriana organization: Laboratoire Cytokines, FRE CNRS 2224, Université de Poitiers, France – sequence: 5 givenname: John surname: Wijdenes fullname: Wijdenes, John organization: DIACLONE Laboratory, Besançon, France – sequence: 6 givenname: Hugues surname: Gascan fullname: Gascan, Hugues organization: INSERM EMI 9928, Centre Hospitalier Universitaire, Angers, France – sequence: 7 givenname: Daniel surname: Potreau fullname: Potreau, Daniel organization: Laboratoire des Biomembranes et Signalisation Cellulaire, UMR CNRS 6558, Université de Poitiers, France – sequence: 8 givenname: Jean-Claude surname: Lecron fullname: Lecron, Jean-Claude organization: Laboratoire Cytokines, FRE CNRS 2224, Université de Poitiers, France |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/12126642$$D View this record in MEDLINE/PubMed |
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Snippet | Interleukin (IL)-6-type cytokines are multifunctional proteins involved in cardiac hypertrophy and myocardial protection. Recent studies, performed on animal... |
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SubjectTerms | Aged Antigens, CD - biosynthesis cardiomyocyte/fibroblast/interleukin-6/interleukin-11/leukaemia inhibitory factor Cells, Cultured Ciliary Neurotrophic Factor - biosynthesis Cytokine Receptor gp130 Cytokines - biosynthesis Cytokines - metabolism Fibroblasts - metabolism Humans Interleukin-11 - biosynthesis Interleukin-6 - biosynthesis Kinetics Leukemia Inhibitory Factor Membrane Glycoproteins - biosynthesis Microscopy, Fluorescence Middle Aged Molecular Chaperones - biosynthesis Myocardium - cytology Myocardium - metabolism Oncostatin M Peptides - metabolism Proteins Receptors, Interleukin-6 - biosynthesis Time Factors |
Title | SECRETION OF IL-6, IL-11 AND LIF BY HUMAN CARDIOMYOCYTES IN PRIMARY CULTURE |
URI | https://dx.doi.org/10.1006/cyto.2002.1033 https://www.ncbi.nlm.nih.gov/pubmed/12126642 https://search.proquest.com/docview/71929653 |
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