Late-Life High Blood Pressure and Enlarged Perivascular Spaces in the Putaminal Regions of Community-Dwelling Japanese Older Persons
Enlarged perivascular spaces (EPVS) of the brain may be involved in dementia, such as Alzheimer's disease and cerebral small vessel disease (CSVD). Hypertension has been reported to be a risk factor for dementia and CSVD, but the association between blood pressure (BP) and perivascular spaces i...
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Published in | Journal of geriatric psychiatry and neurology p. 8919887231195235 |
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Main Authors | , , , , , , , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
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United States
01.01.2024
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Abstract | Enlarged perivascular spaces (EPVS) of the brain may be involved in dementia, such as Alzheimer's disease and cerebral small vessel disease (CSVD). Hypertension has been reported to be a risk factor for dementia and CSVD, but the association between blood pressure (BP) and perivascular spaces is still unclear. The aim of this study was to determine the association between BP and EPVS volumes and to examine the interactions of relevant factors.
A total of 9296 community-dwelling subjects aged ≥65 years participated in a brain magnetic resonance imaging and health status screening examination. Perivascular volume was measured using a software package based on deep learning that was developed in-house. The associations between BP and EPVS volumes were examined by analysis of covariance and multiple regression analysis.
Mean EPVS volumes increased significantly with rising systolic and diastolic BP levels (
for trend = .003,
for trend<.001, respectively). In addition, mean EPVS volumes increased significantly for every 1-mmHg-increment in systolic and diastolic BPs (both
values <.001). These significant associations were still observed in the sensitivity analysis after excluding subjects with dementia.
The present data suggest that higher systolic and diastolic BP levels are associated with greater EPVS volumes in cognitively normal older people. |
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AbstractList | Enlarged perivascular spaces (EPVS) of the brain may be involved in dementia, such as Alzheimer's disease and cerebral small vessel disease (CSVD). Hypertension has been reported to be a risk factor for dementia and CSVD, but the association between blood pressure (BP) and perivascular spaces is still unclear. The aim of this study was to determine the association between BP and EPVS volumes and to examine the interactions of relevant factors.
A total of 9296 community-dwelling subjects aged ≥65 years participated in a brain magnetic resonance imaging and health status screening examination. Perivascular volume was measured using a software package based on deep learning that was developed in-house. The associations between BP and EPVS volumes were examined by analysis of covariance and multiple regression analysis.
Mean EPVS volumes increased significantly with rising systolic and diastolic BP levels (
for trend = .003,
for trend<.001, respectively). In addition, mean EPVS volumes increased significantly for every 1-mmHg-increment in systolic and diastolic BPs (both
values <.001). These significant associations were still observed in the sensitivity analysis after excluding subjects with dementia.
The present data suggest that higher systolic and diastolic BP levels are associated with greater EPVS volumes in cognitively normal older people. |
Author | Ueno, Shu-Ichi Ozaki, Tomoki Mimura, Masaru Ono, Kenjiro Maeda, Tetsuya Tachibana, Ayumi Hata, Jun Yoshida, Taku Ninomiya, Toshiharu Iga, Jun-Ichi Taki, Yasuyuki Chen, Hongkun Yoshino, Yuta Ohara, Tomoyuki Nakaji, Shigeyuki Furuta, Yoshihiko Nakashima, Kenji Thyreau, Benjamin Takebayashi, Minoru Mori, Takaaki Shibata, Mao Tatewaki, Yasuko Shimizu, Hideaki |
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Title | Late-Life High Blood Pressure and Enlarged Perivascular Spaces in the Putaminal Regions of Community-Dwelling Japanese Older Persons |
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