Drug detection in oral fluid and urine after single therapeutic doses of dexamphetamine, lisdexamphetamine, and methylphenidate in healthy volunteers

• Published in: Journal of analytical toxicology Vol. 49; no. 2; pp. 65 - 72
• Main Authors: Helland, Arne, Muller, Sébastien, Spigset, Olav, Krabseth, Hege-Merete, Hansen, Miriam, Skråstad, Ragnhild Bergene
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 15.02.2025
• Subjects: Administration, Oral; Adult; Central Nervous System Stimulants - administration & dosage; Central Nervous System Stimulants - analysis; Central Nervous System Stimulants - pharmacokinetics; Central Nervous System Stimulants - urine; Dexmethylphenidate Hydrochloride - administration & dosage; Dexmethylphenidate Hydrochloride - analysis; Dexmethylphenidate Hydrochloride - urine; Dextroamphetamine - administration & dosage; Dextroamphetamine - analysis; Dextroamphetamine - urine; Editor's Choice; Female; Healthy Volunteers; Humans; Lisdexamfetamine Dimesylate - administration & dosage; Lisdexamfetamine Dimesylate - analysis; Lisdexamfetamine Dimesylate - pharmacokinetics; Lisdexamfetamine Dimesylate - urine; Male; Methylphenidate - administration & dosage; Methylphenidate - analogs & derivatives; Methylphenidate - analysis; Methylphenidate - pharmacokinetics; Methylphenidate - urine; Saliva - chemistry; Substance Abuse Detection - methods; Young Adult

Dexamphetamine, lisdexamphetamine, and methylphenidate are central stimulant drugs widely used to treat attention-deficit/hyperactivity disorder (ADHD), but poor adherence may lead to treatment failure, and the drugs are also subject to misuse and diversion. Drug analysis in oral fluid may thus be u...