Selective Inhibition of Proline Hydroxylation by 3,4-Dehydroproline

• Published in: Plant physiology (Bethesda) Vol. 73; no. 2; pp. 324 - 328
• Main Authors: Cooper, James B., Varner, Joseph E.
• Format: Journal Article
• Language: English
• Published: Rockville, MD American Society of Plant Physiologists 01.10.1983
• Subjects: Amino acids; Biological and medical sciences; Cell growth; Cell walls; Enzymes; Fundamental and applied biological sciences. Psychology; Glycoproteins; Metabolism; Metabolism. Physicochemical requirements; Nitrates; Plant physiology and development; Plant roots; Plants; Protein synthesis; Tritium; Daucus carota; Structure activity relation; Dicotyledones; Angiospermae; Glycoprotein; Spermatophyta; Umbelliferae; Metabolic inhibitor

The effect of proline analogs on peptidyl proline hydroxylation has been studied in vivo using aerated root slices of Daucus carota. One analog, 3,4-dehydroproline, acted at micromolar concentrations to rapidly and selectively inhibit peptidyl proline hydroxylation. A structurally altered hydroxypro...