Cytokines signatures and susceptibility to cutaneous leishmaniasis in patients from Sistan and Baluchestan province of Iran

• Published in: Gene Vol. 903; p. 148224
• Main Authors: Jahanshahi, Saeideh, Nejad, Hamideh Rouhani, Kazemi, Bahram, Saeedi, Pardis
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 20.04.2024
• Subjects: Cutaneous leishmaniasis; Cytokine; DNA; gene frequency; genes; genetic polymorphism; genotype; Genotyping; interleukin-10; Iran; Leishmania; microscopy; parasites; Phlebotominae; Single nucleotide polymorphism (SNP); Iran; Cutaneous leishmaniasis; ORs; Genotyping; SNP; Cytokine; ITS2; CL; Cis; Single nucleotide polymorphism (SNP); ML; cutaneous leishmaniasis; Single Nucleotide Polymorphism (SNP)

•Certain cytokine gene polymorphisms associate with cutaneous leishmaniasis (CL) susceptibility.•Significant differences exist between CL patients and endemic controls for TGF-β1, IFN-γ, and IL-10 variants.•The TGF-β1 (rs1800469) SNP links to over 5-fold greater CL risk in southeastern Iran.•IFN-γ (...