Early Life Environmental Control: Effect on Symptoms, Sensitization, and Lung Function at Age 3 Years

• Published in: American journal of respiratory and critical care medicine Vol. 170; no. 4; pp. 433 - 439
• Main Authors: Woodcock, Ashley, Lowe, Lesley A, Murray, Clare S, Simpson, Bridget M, Pipis, Spyros D, Kissen, Patricia, Simpson, Angela, Custovic, Adnan
• Format: Journal Article
• Language: English
• Published: New York, NY Am Thoracic Soc 15.08.2004; American Lung Association; American Thoracic Society
• Subjects: Allergens - analysis; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Child, Preschool; Comorbidity; Dust - analysis; Environmental Exposure - statistics & numerical data; Female; Follow-Up Studies; Humans; Hypersensitivity - diagnosis; Hypersensitivity - epidemiology; Hypersensitivity - immunology; Hypersensitivity - prevention & control; Immunoglobulin E - blood; Infant, Newborn; Intensive care medicine; Lung Diseases, Obstructive - epidemiology; Lung Diseases, Obstructive - immunology; Male; Medical sciences; Pregnancy; Prenatal Exposure Delayed Effects; Prospective Studies; Respiratory Function Tests; United Kingdom - epidemiology; Allergy; Immunopathology; Lung disease; Intensive care; Respiratory disease; environmental control; Asthma; Atopy; Prevention; Lung function; primary prevention; Bronchus disease; Environmental effect; Obstructive pulmonary disease; Resuscitation

We investigated whether environmental control during pregnancy and early life affects sensitization and lung function at the age of 3 years. High-risk children (n = 251) were prenatally randomized to stringent environmental control (active) or no intervention (control). Questionnaires, skin testing,...