Calcimycin mediates apoptosis in breast and cervical cancer cell lines by inducing intracellular calcium levels in a P2RX4-dependent manner - Neha; Ranjan, Prashant; Das, Parimal (Biochimica et biophysica acta. General subjects, 2024)
Keywords: 4',6-diamidino-2-phenylindole; antagonists; antibiotics; apoptosis; Apoptosis - drug effects; breasts; Calcimycin - pharmacology; calcium; Calcium - metabolism; cations; Cell Cycle Checkpoints - drug effects; cell growth; Cell Line, Tumor; cell lines; Cell Movement - drug effects; Cell Proliferation - drug effects; cytotoxicity; dose response; fluorescence; gene expression; Humans; Intracellular Space - metabolism; ion channels; MCF-7 Cells; mechanism of action; Membrane Potential, Mitochondrial - drug effects; mitochondria; mitogen-activated protein kinase; neoplasm cells; p38 Mitogen-Activated Protein Kinases - metabolism; phosphorylation; Receptors, Purinergic P2X4 - metabolism; Streptomyces; therapeutics; uterine cervical neoplasms; Antiproliferative; P2RX4; Cell death; Calcimycin; p38 MAPK; Ca(2+) signaling; Apoptosis