Antipsychotic Response Worsens With Postmenopausal Duration in Women With Schizophrenia

• Published in: Journal of clinical psychopharmacology Vol. 36; no. 6; p. 580
• Main Authors: González-Rodríguez, Alexandre, Catalán, Rosa, Penadés, Rafael, Ruiz Cortés, Victoria, Torra, Mercè, Seeman, Mary V, Bernardo, Miquel
• Format: Journal Article
• Language: English
• Published: United States 01.12.2016
• Subjects: Aged; Antipsychotic Agents - administration & dosage; Antipsychotic Agents - pharmacology; Female; Humans; Middle Aged; Outcome Assessment (Health Care); Postmenopause; Prospective Studies; Schizophrenia - blood; Schizophrenia - drug therapy; Schizophrenia - physiopathology; Smoking; Time Factors

The loss of estrogens in the menopause may lead to increased vulnerability for psychotic relapse, poor clinical outcome, and a need for increased antipsychotic dose. However, confounders such as cumulative estrogen exposure and time since menopause have been inadequately studied. Our aim was to inve...