Acceleration of Body Clearance of DiethylCarbamazine By Oral Activated Charcoal

• Published in: Pharmacological research Vol. 42; no. 2; pp. 167 - 170
• Main Authors: Orisakwe, Orish E., Ilondu, Ndidi A., Afonne, O.Johnson, Ofoefule, Sabinus I., Orish, Chinna N.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.08.2000
• Subjects: Administration, Oral; Adult; Antidotes - pharmacology; Charcoal - pharmacology; Cross-Over Studies; Diethylcarbamazine - adverse effects; Diethylcarbamazine - blood; Diethylcarbamazine - pharmacokinetics; diethylcarbamazine, total body clearance, activated charcoal, maximum concentration; Drug Interactions; Filaricides - adverse effects; Filaricides - blood; Filaricides - pharmacokinetics; Humans; Male; Metabolic Clearance Rate - drug effects; diethylcarbamazine, total body clearance, activated charcoal, maximum concentration

The effect of activated charcoal (AC) on body clearance of diethylcarbamazine (DEC) was investigated in six healthy volunteers. On three occasions at weekly intervals, each subject received 150 mg of DEC with 350 ml of water. One and two weeks later, 150 mg of DEC plus 7.5 g and 15 g of AC, respecti...