A simple, fast and cost-effective method of synthesis of cupric oxide nanoparticle with promising antibacterial potency: Unraveling the biological and chemical modes of action

• Published in: Biochimica et biophysica acta Vol. 1850; no. 4; pp. 845 - 856
• Main Authors: Chakraborty, Ruchira, Sarkar, Raj Kumar, Chatterjee, Arijit Kumar, Manju, Unnikrishnan, Chattopadhyay, Asoke Prasun, Basu, Tarakdas
• Format: Journal Article
• Language: English
• Published: Netherlands 01.04.2015
• Subjects: agar; Anti-Bacterial Agents - chemical synthesis; Anti-Bacterial Agents - pharmacology; antibacterial properties; antibiotic resistance; antibiotics; atomic force microscopy; Colloids; Copper - pharmacology; cost effectiveness; Cost-Benefit Analysis; Culture Media; cupric oxide; DNA; energy-dispersive X-ray analysis; Escherichia coli; Fourier transform infrared spectroscopy; gel electrophoresis; lipids; mechanism of action; Metal Nanoparticles; minimum inhibitory concentration; nanoparticles; polyvinyl alcohol; Reactive Oxygen Species - metabolism; Staphylococcus aureus; sterilizing; transmission electron microscopy; Antibacterial action; Cupric oxide nanoparticle; ROS generation; Modification of Cu(II) oxide NP; Colloidal suspension; Growth media organics

Gradual attainment of bacterial resistance to antibiotics led us to develop a robust method of synthesis of stable, colloidal cupric oxide nanoparticle of physiological pH with potential antibacterial action. Cu(II) oxide NP was synthesized by reduction-oxidation of CuCl2, using polyvinyl alcohol as...