Proteolysis of tau by granzyme A in tauopathies generates fragments that are aggregation prone

• Published in: Biochemical journal Vol. 481; no. 18; p. 1255
• Main Authors: Quinn, James P, Fisher, Kate, Corbett, Nicola, Warwood, Stacey, Knight, David, Kellett, Katherine A B, Hooper, Nigel M
• Format: Journal Article
• Language: English
• Published: England 18.09.2024
• Subjects: Brain - metabolism; Brain - pathology; CD8-Positive T-Lymphocytes - metabolism; Granzymes - genetics; Granzymes - metabolism; Humans; Protein Aggregation, Pathological - genetics; Protein Aggregation, Pathological - metabolism; Proteolysis; tau Proteins - genetics; tau Proteins - metabolism; Tauopathies - genetics; Tauopathies - metabolism; Tauopathies - pathology; protease; tauopathy; granzyme; tau proteins; Alzheimers disease

Tauopathies, including Alzheimer's disease, corticobasal degeneration and progressive supranuclear palsy, are characterised by the aggregation of tau into insoluble neurofibrillary tangles in the brain. Tau is subject to a range of post-translational modifications, including proteolysis, that c...