Glucose- and arginine-induced insulin secretion by human pancreatic beta-cells: the role of HERG K(+) channels in firing and release

• Published in: The FASEB journal Vol. 14; no. 15; p. 2601
• Main Authors: Rosati, B, Marchetti, P, Crociani, O, Lecchi, M, Lupi, R, Arcangeli, A, Olivotto, M, Wanke, E
• Format: Journal Article
• Language: English
• Published: United States 01.12.2000
• Subjects: Arginine - pharmacology; ATP-Binding Cassette Transporters; Benzimidazoles - pharmacology; Cation Transport Proteins; DNA-Binding Proteins; Electric Conductivity; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Glucose - pharmacology; Humans; Insulin - metabolism; Insulin Secretion; Islets of Langerhans - drug effects; Islets of Langerhans - metabolism; KATP Channels; Patch-Clamp Techniques; Potassium - metabolism; Potassium Channel Blockers; Potassium Channels - metabolism; Potassium Channels, Inwardly Rectifying; Potassium Channels, Voltage-Gated; Radioimmunoassay; Reproducibility of Results; Sulfanilamides - pharmacology; Tolbutamide - pharmacology; Trans-Activators; Transcriptional Regulator ERG

The human ether-a-go-go-related genes (herg) are expressed in tissues other than heart and brain where the HERG K(+) channels are known to regulate the repolarization of the heart action potential and the neuronal spike-frequency accommodation. We provide evidence that herg1 transcripts are present...