A novel bifunctionality: PAT1 and PAT2 mediate electrogenic proton/amino acid and electroneutral proton/fatty acid symport

• Published in: The FASEB journal Vol. 18; no. 14; p. 1758
• Main Authors: Foltz, Martin, Boll, Michael, Raschka, Ladislav, Kottra, Gabor, Daniel, Hannelore
• Format: Journal Article
• Language: English
• Published: United States 01.11.2004
• Subjects: Amino Acid Transport Systems - metabolism; Amino Acids - metabolism; Animals; Biological Transport; Electric Conductivity; Fatty Acids, Volatile - metabolism; Hydrogen-Ion Concentration; Membrane Transport Proteins - metabolism; Oocytes - metabolism; Oocytes - physiology; Patch-Clamp Techniques; Proton Pumps - metabolism; Symporters - metabolism; Xenopus laevis

Recently, the PAT family of proton-dependent amino acid transporters has been identified as a novel class of mammalian amino acid symporters. PAT1 and PAT2 members mediate electrogenic uptake of small, neutral amino acids and derivatives by cotransport of protons. Analysis of the structural requirem...