Analysis of p53 gene mutations in acute myeloid leukemia

• Published in: American journal of hematology Vol. 46; no. 4; p. 304
• Main Authors: Trecca, D, Longo, L, Biondi, A, Cro, L, Calori, R, Grignani, F, Maiolo, A T, Pelicci, P G, Neri, A
• Format: Journal Article
• Language: English
• Published: United States 01.08.1994
• Subjects: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Base Sequence; Child; Child, Preschool; DNA, Single-Stranded - genetics; Female; Humans; Infant; Leukemia, Myeloid - genetics; Male; Middle Aged; Molecular Sequence Data; Mutation; Polymerase Chain Reaction; Polymorphism, Genetic; Tumor Suppressor Protein p53 - genetics

We have previously reported the absence of mutations within exons 5-9 of the p53 gene in a panel of 30 cases of acute promyelocytic leukemia (APL), which represent the M3 FAB type of acute myeloid leukemia (AML). In the present report, we extend our analysis of p53 gene mutations to 70 cases of AML...