Neuroradiological findings (MRS, MRI, SPECT) in infantile neuronal ceroid-lipofuscinosis (infantile CLN1) at different stages of the disease

• Published in: Neuropediatrics Vol. 35; no. 1; p. 27
• Main Authors: Vanhanen, S-L, Puranen, J, Autti, T, Raininko, R, Liewendahl, K, Nikkinen, P, Santavuori, P, Suominen, P, Vuori, K, Häkkinen, A-M
• Format: Journal Article
• Language: English
• Published: Germany 01.02.2004
• Subjects: Aspartic Acid - analogs & derivatives; Aspartic Acid - metabolism; Brain - blood supply; Brain - metabolism; Brain - pathology; Child; Child, Preschool; Choline - metabolism; Creatinine - metabolism; Humans; Infant; Infant, Newborn; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Neuronal Ceroid-Lipofuscinoses - metabolism; Neuronal Ceroid-Lipofuscinoses - pathology; Oximes; Radiopharmaceuticals; Tomography, Emission-Computed, Single-Photon

Infantile neuronal ceroid-lipofuscinosis (infantile CLN1) is a progressive and uniformly fatal lysosomal storage disease of the nervous system. The purpose of this study was to compare the findings of various radiological examinations of the brain in the course of infantile CLN1 in order to evaluate...