The β2 adrenergic receptor regulates morphine tolerance and physical dependence

• Published in: Behavioural brain research Vol. 181; no. 1; pp. 118 - 126
• Main Authors: Liang, De-Yong, Shi, Xiaoyou, Li, Xiangqi, Li, Jun, Clark, J. David
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier B.V 19.07.2007; Elsevier Science
• Subjects: Addictive behaviors; Adult and adolescent clinical studies; Behavioral psychophysiology; Biological and medical sciences; Butoxamine; Drug abuse; Drug addiction; Fundamental and applied biological sciences. Psychology; Gene expression; Medical sciences; Morphine; Null mutant; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Psychopathology. Psychiatry; Drug abuse; Morphine; Butoxamine; Gene expression; Null mutant; Drug addiction; Tolerance; Opiates; β2-Adrenergic receptor; Substance abuse; Narcotic analgesic; Addiction; Dependence; Mutation

Adaptations to the chronic administration of opioids reduce the utility of these drugs in treating pain and support addiction. Recent genetics-based approaches have implicated the β2 adrenergic receptor (β2-AR) in controlling some of these responses. We do not know, however, whether this receptor ca...