Expression of genes encoding bone morphogenetic proteins and sonic hedgehog in talpid (ta3) limb buds: Their relationships in the signalling cascade involved in limb patterning
The chicken mutant talpid3 (ta3) has polydactylous limbs with up to 7–8 morphologically similar digits. This lack of antero–posterior polarity in digit pattern is correlated with symmetrical expression of genes of the HoxD complex. We determined the distribution of polarizing activity in limb buds o...
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Published in | Developmental dynamics Vol. 203; no. 2; pp. 187 - 197 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
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01.06.1995
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Abstract | The chicken mutant talpid3 (ta3) has polydactylous limbs with up to 7–8 morphologically similar digits. This lack of antero–posterior polarity in digit pattern is correlated with symmetrical expression of genes of the HoxD complex. We determined the distribution of polarizing activity in limb buds of the chick mutant ta3 by assessing the ability of mesenchyme from various positions along the antero‐posterior axis to induce digit duplications when grafted anteriorly into a normal limb. Cells with highest polarizing activity were found at the posterior margin of the wing as in the polarizing region of normal limb buds. However, in contrast to normal limb buds, ta3 anterior mesenchyme also had low polarizing activity. Application of retinoic acid or a polarizing region graft to the anterior of ta3 limb buds changed digit morphology but did not induce digit duplications or digits with any characteristic a–p pattern. To determine which genes are associated with polarizing activity and which are associated with patterning of the digits, we examined expression of the genes Sonic hedgehog (shh), Bmp‐2, and Bmp‐7, whose expression is normally confined to the posterior margin of the early wing bud and is associated with the polarizing region. In addition, we determined the distribution of Fgf‐4 transcripts which in normal limb buds are restricted to the posterior part of the apical ectodermal ridge. In ta3 limb buds, shh expression is restricted to the posterior limb mesenchyme, which has high polarizing activity, but is not expressed in regions which have low polarizing activity. In contrast, Bmp‐2 and Bmp‐7 are expressed uniformly along the a–p axis. Fgf‐4 transcripts are present throughout the apical ectodermal ridge in ta3 limb buds. In the ta3 mutant, there is both an abnormal distribution of signalling activity and response to polarizing signals. In addition, the dissociation between the expression of shh and Bmps suggests distinct roles for the encoded molecules in signalling and response in a–p patterning of limb buds. ©1995 Wiley‐Liss, Inc. |
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AbstractList | The chicken mutant talpid3 (ta3) has polydactylous limbs with up to 7-8 morphologically similar digits. This lack of antero-posterior polarity in digit pattern is correlated with symmetrical expression of genes of the HoxD complex. We determined the distribution of polarizing activity in limb buds of the chick mutant ta3 by assessing the ability of mesenchyme from various positions along the antero-posterior axis to induce digit duplications when grafted anteriorly into a normal limb. Cells with highest polarizing activity were found at the posterior margin of the wing as in the polarizing region of normal limb buds. However, in contrast to normal limb buds, ta3 anterior mesenchyme also had low polarizing activity. Application of retinoic acid or a polarizing region graft to the anterior of ta3 limb buds changed digit morphology but did not induce digit duplications or digits with any characteristic a-p pattern. To determine which genes are associated with polarizing activity and which are associated with patterning of the digits, we examined expression of the genes Sonic hedgehog (shh), Bmp-2, and Bmp-7, whose expression is normally confined to the posterior margin of the early wing bud and is associated with the polarizing region. In addition, we determined the distribution of Fgf-4 transcripts which in normal limb buds are restricted to the posterior part of the apical ectodermal ridge. In ta3 limb buds, shh expression is restricted to the posterior limb mesenchyme, which has high polarizing activity, but is not expressed in regions which have low polarizing activity. In contrast, Bmp-2 and Bmp-7 are expressed uniformly along the a-p axis. Fgf-4 transcripts are present throughout the apical ectodermal ridge in ta3 limb buds. In the ta3 mutant, there is both an abnormal distribution of signalling activity and response to polarizing signals. In addition, the dissociation between the expression of shh and Bmps suggests distinct roles for the encoded molecules in signalling and response in a-p patterning of limb buds. Abstract The chicken mutant talpid 3 ( ta 3 ) has polydactylous limbs with up to 7–8 morphologically similar digits. This lack of antero–posterior polarity in digit pattern is correlated with symmetrical expression of genes of the HoxD complex. We determined the distribution of polarizing activity in limb buds of the chick mutant ta 3 by assessing the ability of mesenchyme from various positions along the antero‐posterior axis to induce digit duplications when grafted anteriorly into a normal limb. Cells with highest polarizing activity were found at the posterior margin of the wing as in the polarizing region of normal limb buds. However, in contrast to normal limb buds, ta 3 anterior mesenchyme also had low polarizing activity. Application of retinoic acid or a polarizing region graft to the anterior of ta 3 limb buds changed digit morphology but did not induce digit duplications or digits with any characteristic a–p pattern. To determine which genes are associated with polarizing activity and which are associated with patterning of the digits, we examined expression of the genes Sonic hedgehog ( shh ), Bmp ‐2, and Bmp ‐7, whose expression is normally confined to the posterior margin of the early wing bud and is associated with the polarizing region. In addition, we determined the distribution of Fgf ‐ 4 transcripts which in normal limb buds are restricted to the posterior part of the apical ectodermal ridge. In ta 3 limb buds, shh expression is restricted to the posterior limb mesenchyme, which has high polarizing activity, but is not expressed in regions which have low polarizing activity. In contrast, Bmp ‐2 and Bmp ‐ 7 are expressed uniformly along the a–p axis. Fgf ‐ 4 transcripts are present throughout the apical ectodermal ridge in ta 3 limb buds. In the ta 3 mutant, there is both an abnormal distribution of signalling activity and response to polarizing signals. In addition, the dissociation between the expression of shh and Bmps suggests distinct roles for the encoded molecules in signalling and response in a–p patterning of limb buds. ©1995 Wiley‐Liss, Inc. The chicken mutant talpid3 (ta3) has polydactylous limbs with up to 7–8 morphologically similar digits. This lack of antero–posterior polarity in digit pattern is correlated with symmetrical expression of genes of the HoxD complex. We determined the distribution of polarizing activity in limb buds of the chick mutant ta3 by assessing the ability of mesenchyme from various positions along the antero‐posterior axis to induce digit duplications when grafted anteriorly into a normal limb. Cells with highest polarizing activity were found at the posterior margin of the wing as in the polarizing region of normal limb buds. However, in contrast to normal limb buds, ta3 anterior mesenchyme also had low polarizing activity. Application of retinoic acid or a polarizing region graft to the anterior of ta3 limb buds changed digit morphology but did not induce digit duplications or digits with any characteristic a–p pattern. To determine which genes are associated with polarizing activity and which are associated with patterning of the digits, we examined expression of the genes Sonic hedgehog (shh), Bmp‐2, and Bmp‐7, whose expression is normally confined to the posterior margin of the early wing bud and is associated with the polarizing region. In addition, we determined the distribution of Fgf‐4 transcripts which in normal limb buds are restricted to the posterior part of the apical ectodermal ridge. In ta3 limb buds, shh expression is restricted to the posterior limb mesenchyme, which has high polarizing activity, but is not expressed in regions which have low polarizing activity. In contrast, Bmp‐2 and Bmp‐7 are expressed uniformly along the a–p axis. Fgf‐4 transcripts are present throughout the apical ectodermal ridge in ta3 limb buds. In the ta3 mutant, there is both an abnormal distribution of signalling activity and response to polarizing signals. In addition, the dissociation between the expression of shh and Bmps suggests distinct roles for the encoded molecules in signalling and response in a–p patterning of limb buds. ©1995 Wiley‐Liss, Inc. |
Author | Rodriguez, C. Robertson, K. E. Brickell, P. M. Francis‐West, P. H. Ede, D. A. Izpisúa‐Belmonte, J. C. Houston, B. Gribbin, C. Burt, D. W. Tickle, C. |
Author_xml | – sequence: 1 givenname: P. H. surname: Francis‐West fullname: Francis‐West, P. H. – sequence: 2 givenname: K. E. surname: Robertson fullname: Robertson, K. E. – sequence: 3 givenname: D. A. surname: Ede fullname: Ede, D. A. – sequence: 4 givenname: C. surname: Rodriguez fullname: Rodriguez, C. – sequence: 5 givenname: J. C. surname: Izpisúa‐Belmonte fullname: Izpisúa‐Belmonte, J. C. – sequence: 6 givenname: B. surname: Houston fullname: Houston, B. – sequence: 7 givenname: D. W. surname: Burt fullname: Burt, D. W. – sequence: 8 givenname: C. surname: Gribbin fullname: Gribbin, C. – sequence: 9 givenname: P. M. surname: Brickell fullname: Brickell, P. M. – sequence: 10 givenname: C. surname: Tickle fullname: Tickle, C. |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/7655081$$D View this record in MEDLINE/PubMed |
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Cites_doi | 10.1038/372175a0 10.1016/0047-6374(73)90002-X 10.1038/371609a0 10.1038/368208a0 10.1242/dev.119.1.199 10.1038/327625a0 10.1038/254199a0 10.1515/9783110861082-009 10.1002/aja.1001930107 10.1073/pnas.84.14.5082 10.1677/jme.0.0130289 10.1016/0092-8674(93)90391-3 10.1242/dev.115.2.629 10.1101/gad.3.11.1657 10.1038/350585a0 10.1016/S0021-9258(19)38285-7 10.1242/dev.117.4.1421 10.1016/0092-8674(95)90352-6 10.1002/j.1460-2075.1992.tb05189.x 10.1038/296564a0 10.1242/dev.114.4.959 10.1016/0092-8674(94)90030-2 10.1016/0012-1606(85)90348-3 10.1016/0092-8674(93)90626-2 10.1242/dev.115.2.553 10.1006/dbio.1994.1195 10.1016/0092-8674(93)90512-O 10.1016/0092-8674(91)90274-3 10.1002/jmor.1050880104 10.1242/dev.120.1.209 |
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References | 1989; 3 1992c; 5 1991; 350 1985; 109 1994; 372 1987; 327 1951; 88 1975; 254 1985; 86 1964a; 12 1985; 87 1994; 317 1990; 265 1992b; 114 1993; 117 1992; 193 1995; 80 1987; 84 1992a; 11 1994; 368 1993; 119 1964b; 12 1994; 164 1994; 120 1991; 64 1993; 75 1992; 115 1993; 74 1967; 17 1982; 296 1994; 13 1994; 79 1980 1973; 2 1968 Vogel A. (e_1_2_1_38_1) 1993; 119 Hinchliffe J. R. (e_1_2_1_14_1) 1967; 17 Hinchliffe J. R. (e_1_2_1_15_1) 1980 Hinchliffe J. R. (e_1_2_1_16_1) 1985; 86 Ede D. A. (e_1_2_1_11_1) 1964; 12 Ede D. A. (e_1_2_1_9_1) 1980 e_1_2_1_20_1 e_1_2_1_24_1 Sampath T. K. (e_1_2_1_32_1) 1990; 265 e_1_2_1_21_1 e_1_2_1_27_1 e_1_2_1_28_1 e_1_2_1_25_1 e_1_2_1_26_1 Izpisúa‐Belmonte J.‐C. (e_1_2_1_22_1) 1992; 114 e_1_2_1_29_1 Izpisúa‐Belmonte J.‐C. (e_1_2_1_23_1) 1992; 5 e_1_2_1_7_1 e_1_2_1_31_1 e_1_2_1_8_1 e_1_2_1_30_1 e_1_2_1_6_1 Anderson R. (e_1_2_1_2_1) 1993; 117 e_1_2_1_3_1 e_1_2_1_12_1 Saunders J. W. (e_1_2_1_33_1) 1968 e_1_2_1_35_1 e_1_2_1_4_1 e_1_2_1_13_1 e_1_2_1_34_1 Coelho C. N. D. (e_1_2_1_5_1) 1992; 115 Ede D. A. (e_1_2_1_10_1) 1964; 12 e_1_2_1_37_1 e_1_2_1_36_1 Honig L. S. (e_1_2_1_17_1) 1985; 87 e_1_2_1_18_1 e_1_2_1_19_1 |
References_xml | – volume: 64 start-page: 1197 year: 1991 end-page: 1205 article-title: Involvement of the Chox‐4 chicken homeobox genes in determination of anteroposterior axial polarity during limb development publication-title: Cell – volume: 117 start-page: 421 year: 1993 end-page: 433 article-title: Maintenance of ZPA signaling in cultured mouse limb bud cells publication-title: Development – start-page: 53 year: 1980 end-page: 66 – volume: 86 start-page: 169 year: 1985 end-page: 175 article-title: The distribution of the polarizing zone (ZPA) in the leg bud of the chick embryo publication-title: J. Embryol. Exp. Morphol. – volume: 265 start-page: 13198 year: 1990 end-page: 13205 article-title: Bovine osteogenic protein is composed of OP‐1 and BMP‐2A, two members of the transforming growth factor‐B superfamily publication-title: J. Biol. Chem. – volume: 75 start-page: 579 year: 1993 end-page: 587 article-title: FGF‐4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb publication-title: Cell – volume: 109 start-page: 92 year: 1985 end-page: 95 article-title: A quantitative analysis of the effect of all‐ ‐retinoic acid on the pattern of chick wing development publication-title: Dev. Biol. – volume: 120 start-page: 209 year: 1994 end-page: 218 article-title: Bone morphogenetic proteins and a signalling pathway that controls patterning in the developing chick limb publication-title: Development – volume: 368 start-page: 208 year: 1994 end-page: 214 article-title: Compartment boundaries and the control of limb pattern by hedgehog protein publication-title: Nature – volume: 119 start-page: 199 year: 1993 end-page: 206 article-title: FGF‐4 maintains polarizing activity of posterior limb buds cells in vivo and in vitro publication-title: Development – volume: 88 start-page: 49 year: 1951 end-page: 92 article-title: A series of normal stages in the development of the chick embryo publication-title: J. Morphol. – start-page: 78 year: 1968 end-page: 97 – volume: 17 start-page: 385 year: 1967 end-page: 404 article-title: Limb development in the polydactylous mutant of the fowl publication-title: J. Embryol. Exp. Morphol. – volume: 75 start-page: 1401 year: 1993 end-page: 1416 article-title: Sonic hedgehog mediates the polarizing activity of the ZPA publication-title: Cell – volume: 12 start-page: 339 year: 1964a end-page: 356 article-title: Developmental abnormalities in the trunk and limbs of the mutant of the fowl publication-title: J. Embryol. Exp. Morphol. – volume: 164 start-page: 241 year: 1994 end-page: 257 article-title: Conversion of anterior limb bud cells to ZPA signaling cells in vitro and in vivo publication-title: Dev. Biol. – volume: 79 start-page: 993 year: 1994 end-page: 1003 article-title: Sonic Hedgehog and Fgf‐4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud publication-title: Cell – volume: 114 start-page: 959 year: 1992b end-page: 963 article-title: The mis‐expression of posterior Hox‐4 genes in Talpid (ta3) mutant wings correlates with the absence of antero‐posterior polarity publication-title: Development – volume: 3 start-page: 1657 year: 1989 end-page: 1668 article-title: Patterns of expression of murine Vgr‐1 and BMP2a RNA suggest that transforming growth factor‐B‐like genes coordinately regulate aspects of embryonic development publication-title: Genes Dev. – volume: 74 start-page: 645 year: 1993 end-page: 659 article-title: The Homeobox gene goosecoid and the origin of organiser cells in the early chick blastoderm publication-title: Cell – volume: 5 start-page: 553 year: 1992c end-page: 560 article-title: Hox‐4 gene expression in mouse/chicken heterospecific grafts of signalling regions to limb buds reveals similarities in patterning mechanisms publication-title: Development 1 – volume: 12 start-page: 161 year: 1964b end-page: 182 article-title: Developmental abnormalities in the head region of the mutant of the fowl publication-title: J. Embryol. Exp. Morphol. – volume: 372 start-page: 175 year: 1994 end-page: 179 article-title: Cell interaction between compartments establishes the proximal‐distal axis of legs publication-title: Nature – volume: 11 start-page: 1451 year: 1992a end-page: 1457 article-title: Expression of Hox‐4 genes in the chick wing links pattern formation to the epithelial‐mesenchymal interactions that mediate growth publication-title: EMBO J. – volume: 296 start-page: 564 year: 1982 end-page: 565 article-title: Local application of retinoic acid to the limb bud mimics the action of the polarizing region publication-title: Nature – year: 1980 – volume: 254 start-page: 199 year: 1975 end-page: 202 article-title: Positional signalling and specification of digits in chick limb morphogenesis publication-title: Nature – volume: 2 start-page: 1 year: 1973 end-page: 12 article-title: Spatiotemporal distribution of mechanisms that control outgrowth and anteroposterior polarizing of the limb bud in the chick embryo publication-title: Mech. Ageing Dev. – volume: 84 start-page: 5082 year: 1987 end-page: 5086 article-title: Heterodimers and homodimers of inhibin subunits have different paracrine action in the modulation of luteinizing hormone‐stimulated androgen biosynthesis publication-title: Proc. Natl. Acad. Sci. U.S.A. – volume: 317 start-page: 609 year: 1994 end-page: 612 article-title: A positive feedback loop coordinates growth and patterning in the vertebrate limb publication-title: Nature – volume: 13 start-page: 289 year: 1994 end-page: 301 article-title: Molecular cloning and expression of bone morphogenetic protein‐7 in the chick epiphyseal growth plate publication-title: J. Mol. Endocrinol. – volume: 193 start-page: 40 year: 1992 end-page: 48 article-title: The chick limb has weak polarizing activity and can respond to retinoic acid and polarizing zone signal publication-title: Dev. Dyn. – volume: 350 start-page: 585 year: 1991 end-page: 589 article-title: Expression of the homeobox Hox‐4 genes and the specification of position in chick wing development publication-title: Nature – volume: 115 start-page: 629 year: 1992 end-page: 637 article-title: Role of the chicken homeobox genes GHox‐4. 6 and GHox‐8 in the specification of positional identities during the development of normal and polydactylous chick limb buds publication-title: Development – volume: 87 start-page: 163 year: 1985 end-page: 174 article-title: Maps of strength of positional signalling activity in the developing chick wing bud publication-title: J. Embryol. Exp. Morphol. – volume: 80 start-page: 239 year: 1995 end-page: 246 article-title: Fibroblast growth factors induce additional limb development from the flank of chick embryos publication-title: Cell – volume: 327 start-page: 625 year: 1987 end-page: 628 article-title: Identification and spatial distribution of retinoids in the developing chick limb publication-title: Nature – ident: e_1_2_1_7_1 doi: 10.1038/372175a0 – ident: e_1_2_1_27_1 doi: 10.1016/0047-6374(73)90002-X – ident: e_1_2_1_29_1 doi: 10.1038/371609a0 – ident: e_1_2_1_4_1 doi: 10.1038/368208a0 – volume: 119 start-page: 199 year: 1993 ident: e_1_2_1_38_1 article-title: FGF‐4 maintains polarizing activity of posterior limb buds cells in vivo and in vitro publication-title: Development doi: 10.1242/dev.119.1.199 contributor: fullname: Vogel A. – volume: 12 start-page: 161 year: 1964 ident: e_1_2_1_11_1 article-title: Developmental abnormalities in the head region of the talpid 3 mutant of the fowl publication-title: J. Embryol. Exp. Morphol. contributor: fullname: Ede D. A. – volume-title: Development of the Vertebrate Limb year: 1980 ident: e_1_2_1_15_1 contributor: fullname: Hinchliffe J. R. – ident: e_1_2_1_34_1 doi: 10.1038/327625a0 – ident: e_1_2_1_36_1 doi: 10.1038/254199a0 – volume: 86 start-page: 169 year: 1985 ident: e_1_2_1_16_1 article-title: The distribution of the polarizing zone (ZPA) in the leg bud of the chick embryo publication-title: J. Embryol. Exp. Morphol. contributor: fullname: Hinchliffe J. R. – start-page: 53 volume-title: Teratology of the Limbs year: 1980 ident: e_1_2_1_9_1 doi: 10.1515/9783110861082-009 contributor: fullname: Ede D. A. – volume: 87 start-page: 163 year: 1985 ident: e_1_2_1_17_1 article-title: Maps of strength of positional signalling activity in the developing chick wing bud publication-title: J. Embryol. Exp. Morphol. contributor: fullname: Honig L. S. – volume: 12 start-page: 339 year: 1964 ident: e_1_2_1_10_1 article-title: Developmental abnormalities in the trunk and limbs of the talpid 3 mutant of the fowl publication-title: J. Embryol. Exp. Morphol. contributor: fullname: Ede D. A. – ident: e_1_2_1_8_1 doi: 10.1002/aja.1001930107 – volume: 17 start-page: 385 year: 1967 ident: e_1_2_1_14_1 article-title: Limb development in the polydactylous talpid 3 mutant of the fowl publication-title: J. Embryol. Exp. Morphol. contributor: fullname: Hinchliffe J. R. – ident: e_1_2_1_19_1 doi: 10.1073/pnas.84.14.5082 – ident: e_1_2_1_18_1 doi: 10.1677/jme.0.0130289 – ident: e_1_2_1_28_1 doi: 10.1016/0092-8674(93)90391-3 – volume: 115 start-page: 629 year: 1992 ident: e_1_2_1_5_1 article-title: Role of the chicken homeobox genes GHox‐4. 6 and GHox‐8 in the specification of positional identities during the development of normal and polydactylous chick limb buds publication-title: Development doi: 10.1242/dev.115.2.629 contributor: fullname: Coelho C. N. D. – ident: e_1_2_1_26_1 doi: 10.1101/gad.3.11.1657 – ident: e_1_2_1_20_1 doi: 10.1038/350585a0 – volume: 265 start-page: 13198 year: 1990 ident: e_1_2_1_32_1 article-title: Bovine osteogenic protein is composed of OP‐1 and BMP‐2A, two members of the transforming growth factor‐B superfamily publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(19)38285-7 contributor: fullname: Sampath T. K. – volume: 117 start-page: 421 year: 1993 ident: e_1_2_1_2_1 article-title: Maintenance of ZPA signaling in cultured mouse limb bud cells publication-title: Development doi: 10.1242/dev.117.4.1421 contributor: fullname: Anderson R. – ident: e_1_2_1_6_1 doi: 10.1016/0092-8674(95)90352-6 – ident: e_1_2_1_21_1 doi: 10.1002/j.1460-2075.1992.tb05189.x – ident: e_1_2_1_37_1 doi: 10.1038/296564a0 – volume: 114 start-page: 959 year: 1992 ident: e_1_2_1_22_1 article-title: The mis‐expression of posterior Hox‐4 genes in Talpid (ta3) mutant wings correlates with the absence of antero‐posterior polarity publication-title: Development doi: 10.1242/dev.114.4.959 contributor: fullname: Izpisúa‐Belmonte J.‐C. – ident: e_1_2_1_25_1 doi: 10.1016/0092-8674(94)90030-2 – ident: e_1_2_1_35_1 doi: 10.1016/0012-1606(85)90348-3 – ident: e_1_2_1_31_1 doi: 10.1016/0092-8674(93)90626-2 – volume: 5 start-page: 553 year: 1992 ident: e_1_2_1_23_1 article-title: Hox‐4 gene expression in mouse/chicken heterospecific grafts of signalling regions to limb buds reveals similarities in patterning mechanisms publication-title: Development 1 doi: 10.1242/dev.115.2.553 contributor: fullname: Izpisúa‐Belmonte J.‐C. – ident: e_1_2_1_3_1 doi: 10.1006/dbio.1994.1195 – ident: e_1_2_1_24_1 doi: 10.1016/0092-8674(93)90512-O – ident: e_1_2_1_30_1 doi: 10.1016/0092-8674(91)90274-3 – ident: e_1_2_1_13_1 doi: 10.1002/jmor.1050880104 – ident: e_1_2_1_12_1 doi: 10.1242/dev.120.1.209 – start-page: 78 volume-title: Epithelial‐Mesenchymal Interactions year: 1968 ident: e_1_2_1_33_1 contributor: fullname: Saunders J. W. |
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Snippet | The chicken mutant talpid3 (ta3) has polydactylous limbs with up to 7–8 morphologically similar digits. This lack of antero–posterior polarity in digit pattern... The chicken mutant talpid3 (ta3) has polydactylous limbs with up to 7-8 morphologically similar digits. This lack of antero-posterior polarity in digit pattern... Abstract The chicken mutant talpid 3 ( ta 3 ) has polydactylous limbs with up to 7–8 morphologically similar digits. This lack of antero–posterior polarity in... |
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SubjectTerms | Animals a–p patterning Bmp Bone Morphogenetic Protein 7 Bone Morphogenetic Proteins Chick Embryo - physiology Chromosome Mapping Embryonic and Fetal Development Extremities - embryology Fgf‐4 Fibroblast Growth Factor 4 Fibroblast Growth Factors - genetics Gene Expression Genes Hedgehog Proteins Limb Mesoderm - drug effects Mutation Polarizing activity Proteins - genetics Proto-Oncogene Proteins - genetics shh Signal Transduction Trans-Activators Transforming Growth Factor beta Tretinoin - pharmacology |
Title | Expression of genes encoding bone morphogenetic proteins and sonic hedgehog in talpid (ta3) limb buds: Their relationships in the signalling cascade involved in limb patterning |
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