Developmental exposure to the Parkinson’s disease-associated organochlorine pesticide dieldrin alters dopamine neurotransmission in α-synuclein pre-formed fibril (PFF)-injected mice

• Published in: Toxicological sciences Vol. 196; no. 1; pp. 99 - 111
• Main Authors: Boyd, Sierra L, Kuhn, Nathan C, Patterson, Joseph R, Stoll, Anna C, Zimmerman, Sydney A, Kolanowski, Mason R, Neubecker, Joseph J, Luk, Kelvin C, Ramsson, Eric S, Sortwell, Caryl E, Bernstein, Alison I
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 30.10.2023
• Subjects: alpha-Synuclein - metabolism; Animals; Dieldrin - toxicity; Dopamine; Female; Male; Mice; Mice, Inbred C57BL; Neurotoxicology; Parkinson Disease; Pesticides - toxicity; Substantia Nigra - metabolism; Synaptic Transmission; Synucleinopathies; Vesicular Monoamine Transport Proteins; Parkinson disease; dieldrin; alpha-synuclein; pesticides; dopamine; developmental neurotoxicity

Abstract Parkinson’s disease (PD) is the fastest-growing neurological disease worldwide, with increases outpacing aging and occurring most rapidly in recently industrialized areas, suggesting a role of environmental factors. Epidemiological, post-mortem, and mechanistic studies suggest that persiste...