Transactivation of the Mouse Sulfonylurea Receptor I Gene by BETA2/NeuroD

• Published in: Molecular endocrinology (Baltimore, Md.) Vol. 16; no. 5; pp. 1097 - 1107
• Main Authors: Kim, Ji-Won, Seghers, Victor, Cho, Jang-Hyeon, Kang, Yup, Kim, Soyeon, Ryu, Yoonseok, Baek, Kwanghee, Aguilar-Bryan, Lydia, Lee, Young-Don, Bryan, Joseph, Suh-Kim, Haeyoung
• Format: Journal Article
• Language: English
• Published: Endocrine Society 01.05.2002; Oxford University Press

The sulfonylurea receptor 1 (SUR1) plays a key role in regulation of insulin secretion in pancreatic β-cells. In this study we investigated the mechanism for tissue-specific expression of the SUR1 gene. A −138/−20 fragment exhibited basal promoter activity while the −660/−20 fragment contained a reg...