New Perspectives of Dyrk1A Role in Neurogenesis and Neuropathologic Features of Down Syndrome
Down syndrome (DS) is one of the most common genetic disorders accompanying with mental retardation, cognitive impairment, and deficits in learning and memory. The brains with DS also display many neuropathological features including alteration in neurogenesis and synaptogenesis and early onset of A...
Saved in:
| Published in | Experimental neurobiology Vol. 22; no. 4; pp. 244 - 248 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Korea (South)
The Korean Society for Brain and Neural Science
01.12.2013
한국뇌신경과학회 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1226-2560 2093-8144 |
| DOI | 10.5607/en.2013.22.4.244 |
Cover
| Abstract | Down syndrome (DS) is one of the most common genetic disorders accompanying with mental retardation, cognitive impairment, and deficits in learning and memory. The brains with DS also display many neuropathological features including alteration in neurogenesis and synaptogenesis and early onset of Alzheimer's disease (AD)-like symptoms. Triplication of all or a part of human chromosome 21, especially the 21q22.1~21q22.3 region called 'Down syndrome critical region (DSCR)', has been considered as the main cause of DS. One gene product of DSCR, dual-specificity tyrosine-phosphorylation-regulated kinase 1A (Dyrk1A), has been highlighted as a key contributor to the neural consequences of DS. This minireview summarizes accumulating recent reports about Dyrk1A involvement in the neuritogenesis, synaptogenesis, and AD-like neurofibrillary tangle formation, which is mainly focusing on Dyrk1A-mediated regulation of cytoskeletal proteins, such as tubulin, actin, and microtubule-associated protein tau. Understanding the molecular mechanisms of these phenomena may provide us a rational for new preventive and therapeutic treatment of DS. |
|---|---|
| AbstractList | Down syndrome (DS) is one of the most common genetic disorders accompanying with mental retardation, cognitive impairment,and deficits in learning and memory. The brains with DS also display many neuropathological features including alteration inneurogenesis and synaptogenesis and early onset of Alzheimer’s disease (AD)-like symptoms. Triplication of all or a part of humanchromosome 21, especially the 21q22.1~21q22.3 region called ‘Down syndrome critical region (DSCR)’, has been considered asthe main cause of DS. One gene product of DSCR, dual-specificity tyrosine-phosphorylation-regulated kinase 1A (Dyrk1A), hasbeen highlighted as a key contributor to the neural consequences of DS. This minireview summarizes accumulating recent reportsabout Dyrk1A involvement in the neuritogenesis, synaptogenesis, and AD-like neurofibrillary tangle formation, which is mainlyfocusing on Dyrk1A-mediated regulation of cytoskeletal proteins, such as tubulin, actin, and microtubule-associated protein tau.
Understanding the molecular mechanisms of these phenomena may provide us a rational for new preventive and therapeutictreatment of DS. KCI Citation Count: 0 Down syndrome (DS) is one of the most common genetic disorders accompanying with mental retardation, cognitive impairment, and deficits in learning and memory. The brains with DS also display many neuropathological features including alteration in neurogenesis and synaptogenesis and early onset of Alzheimer's disease (AD)-like symptoms. Triplication of all or a part of human chromosome 21, especially the 21q22.1~21q22.3 region called 'Down syndrome critical region (DSCR)', has been considered as the main cause of DS. One gene product of DSCR, dual-specificity tyrosine-phosphorylation-regulated kinase 1A (Dyrk1A), has been highlighted as a key contributor to the neural consequences of DS. This minireview summarizes accumulating recent reports about Dyrk1A involvement in the neuritogenesis, synaptogenesis, and AD-like neurofibrillary tangle formation, which is mainly focusing on Dyrk1A-mediated regulation of cytoskeletal proteins, such as tubulin, actin, and microtubule-associated protein tau. Understanding the molecular mechanisms of these phenomena may provide us a rational for new preventive and therapeutic treatment of DS.Down syndrome (DS) is one of the most common genetic disorders accompanying with mental retardation, cognitive impairment, and deficits in learning and memory. The brains with DS also display many neuropathological features including alteration in neurogenesis and synaptogenesis and early onset of Alzheimer's disease (AD)-like symptoms. Triplication of all or a part of human chromosome 21, especially the 21q22.1~21q22.3 region called 'Down syndrome critical region (DSCR)', has been considered as the main cause of DS. One gene product of DSCR, dual-specificity tyrosine-phosphorylation-regulated kinase 1A (Dyrk1A), has been highlighted as a key contributor to the neural consequences of DS. This minireview summarizes accumulating recent reports about Dyrk1A involvement in the neuritogenesis, synaptogenesis, and AD-like neurofibrillary tangle formation, which is mainly focusing on Dyrk1A-mediated regulation of cytoskeletal proteins, such as tubulin, actin, and microtubule-associated protein tau. Understanding the molecular mechanisms of these phenomena may provide us a rational for new preventive and therapeutic treatment of DS. Down syndrome (DS) is one of the most common genetic disorders accompanying with mental retardation, cognitive impairment, and deficits in learning and memory. The brains with DS also display many neuropathological features including alteration in neurogenesis and synaptogenesis and early onset of Alzheimer's disease (AD)-like symptoms. Triplication of all or a part of human chromosome 21, especially the 21q22.1~21q22.3 region called 'Down syndrome critical region (DSCR)', has been considered as the main cause of DS. One gene product of DSCR, dual-specificity tyrosine-phosphorylation-regulated kinase 1A (Dyrk1A), has been highlighted as a key contributor to the neural consequences of DS. This minireview summarizes accumulating recent reports about Dyrk1A involvement in the neuritogenesis, synaptogenesis, and AD-like neurofibrillary tangle formation, which is mainly focusing on Dyrk1A-mediated regulation of cytoskeletal proteins, such as tubulin, actin, and microtubule-associated protein tau. Understanding the molecular mechanisms of these phenomena may provide us a rational for new preventive and therapeutic treatment of DS. |
| Author | Chung, Kwang Chul Park, Joongkyu |
| AuthorAffiliation | 1 Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University, Seoul 120-749, Korea 2 Program in Cellular Neuroscience, Neurodegeneration and Repair (CNNR), Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510, USA |
| AuthorAffiliation_xml | – name: 1 Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University, Seoul 120-749, Korea – name: 2 Program in Cellular Neuroscience, Neurodegeneration and Repair (CNNR), Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510, USA |
| Author_xml | – sequence: 1 givenname: Joongkyu surname: Park fullname: Park, Joongkyu organization: Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University, Seoul 120-749, Korea, Program in Cellular Neuroscience, Neurodegeneration and Repair (CNNR), Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510, USA – sequence: 2 givenname: Kwang Chul surname: Chung fullname: Chung, Kwang Chul organization: Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University, Seoul 120-749, Korea |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24465139$$D View this record in MEDLINE/PubMed https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART001844395$$DAccess content in National Research Foundation of Korea (NRF) |
| BookMark | eNp1kU1v1DAQhi1URJfSOyfkI5ek_k5yQVoVSitVBZVyRJbjTLZms3awk1b77_F2W74kfBnJfp55R56X6MAHDwi9pqSUilQn4EtGKC8ZK0XJhHiGFow0vKipEAdoQRlTBcvkITpO6TvJR8pGUvUCHWZaScqbBfp2Bff4M8Q0gp3cHSQcevx-G9d0ia_DANh5fAVzDCvwkFzCxnf7i9FMt2EIK2fxGZhpjo9uuPf4y9Z3MWzgFXremyHB8WM9Ql_PPtycnheXnz5enC4vC8sFEQUD07WilZwY07NOCaJ6DlUviWoJNKq2RklBrGh53akM8LrlRDLa2qqubceP0Nt9Xx97vbZOB-Me6iroddTL65sLLVjFRZ3Rd3t0nNsNdBb8FM2gx-g2Jm4fxL9fvLvNbe40r5tK1fJ31hjDjxnSpDcuWRgG4yHMSdM8KaWEcZrRN39m_Qp5-v4MqD1gY0gpQq-tm8zkwi7aDZoSvVu1Bq93q9aMabGzs0j-EZ96_1f5Cc4fq6M |
| CitedBy_id | crossref_primary_10_1016_j_ejmech_2024_116409 crossref_primary_10_1007_s00726_015_1941_1 crossref_primary_10_1111_jcmm_17817 crossref_primary_10_3389_fcell_2023_1277537 crossref_primary_10_1016_j_nbd_2017_06_010 crossref_primary_10_1371_journal_pone_0132453 crossref_primary_10_7554_eLife_88318 crossref_primary_10_1248_yakushi_16_00236_2 crossref_primary_10_1002_mgg3_334 crossref_primary_10_1016_j_ijbiomac_2024_132024 crossref_primary_10_1038_s41420_022_01290_0 crossref_primary_10_3390_genes12111833 crossref_primary_10_1371_journal_pbio_3002097 crossref_primary_10_3389_fnins_2024_1485499 crossref_primary_10_7705_biomedica_5354 crossref_primary_10_1016_j_bbamcr_2023_119611 crossref_primary_10_1074_jbc_RA120_015574 crossref_primary_10_3390_ijms18081627 crossref_primary_10_3233_JAD_190475 crossref_primary_10_3390_biomedicines10061380 crossref_primary_10_3389_fnins_2024_1462893 crossref_primary_10_1016_j_jbc_2024_107206 crossref_primary_10_3389_fcell_2022_877711 crossref_primary_10_7554_eLife_88318_3 crossref_primary_10_1038_ejhg_2015_29 crossref_primary_10_1002_mgg3_1544 crossref_primary_10_1038_mp_2015_5 crossref_primary_10_1016_j_nbd_2023_106359 crossref_primary_10_1007_s10571_021_01060_z crossref_primary_10_1155_2015_382530 crossref_primary_10_1016_j_celrep_2021_109226 crossref_primary_10_1093_hmg_ddv284 crossref_primary_10_1016_j_pbb_2022_173404 crossref_primary_10_1038_s41598_020_67133_z crossref_primary_10_1016_j_ejmech_2015_06_046 crossref_primary_10_1111_jnc_13164 crossref_primary_10_15252_embr_201540374 crossref_primary_10_3390_ijms22169083 crossref_primary_10_3389_fnbeh_2016_00104 crossref_primary_10_1016_j_scr_2018_10_023 crossref_primary_10_1007_s40142_014_0043_9 crossref_primary_10_1371_journal_pone_0207779 crossref_primary_10_1242_bio_032862 crossref_primary_10_3389_fncel_2014_00331 crossref_primary_10_1016_j_celrep_2018_04_008 |
| Cites_doi | 10.1016/0888-7543(89)90065-7 10.1007/s00018-009-0123-2 10.1016/S0140-6736(03)12987-X 10.1038/nm0196-93 10.1074/jbc.M112.355412 10.1007/s00401-008-0419-6 10.5483/BMBRep.2009.42.1.006 10.1097/NEN.0b013e31827733c8 10.1016/j.mcn.2007.07.007 10.1159/000472398 10.1042/BJ20070797 10.1038/nrg1448 10.1016/j.freeradbiomed.2005.03.023 10.1371/journal.pone.0004606 10.1016/0022-510X(87)90223-1 10.1371/journal.pone.0078561 10.1007/s11064-007-9494-7 10.1007/BF00294247 10.1007/BF00688755 10.1212/WNL.35.7.957 10.1002/hipo.20308 10.1042/bj3550609 10.1074/jbc.M707358200 10.1074/jbc.275.4.2431 10.1016/S0140-6736(99)05264-2 10.1242/jcs.040162 10.1091/mbc.E04-12-1085 10.1371/journal.pone.0019264 10.1016/j.cub.2008.02.005 10.1002/ana.410170310 10.1111/j.1742-4658.2009.07346.x 10.1093/cercor/bhr362 10.1111/j.1365-2559.1988.tb02018.x 10.1186/gb-2009-10-3-r26 10.1242/jcs.086124 10.1096/fj.07-104539 |
| ContentType | Journal Article |
| Copyright | Copyright © Experimental Neurobiology 2013. 2013 |
| Copyright_xml | – notice: Copyright © Experimental Neurobiology 2013. 2013 |
| DBID | AAYXX CITATION NPM 7X8 5PM ACYCR |
| DOI | 10.5607/en.2013.22.4.244 |
| DatabaseName | CrossRef PubMed MEDLINE - Academic PubMed Central (Full Participant titles) Korean Citation Index |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic PubMed |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Anatomy & Physiology |
| EISSN | 2093-8144 |
| EndPage | 248 |
| ExternalDocumentID | oai_kci_go_kr_ARTI_427348 PMC3897685 24465139 10_5607_en_2013_22_4_244 |
| Genre | Journal Article Review |
| GrantInformation_xml | – fundername: National Research Foundation grantid: 2007-0056092 – fundername: Ministry for Health and Welfare grantid: A092004 – fundername: Ministry for Health and Welfare grantid: A111653 – fundername: National Research Foundation grantid: 2012R1A6A3A03039314 – fundername: National Research Foundation grantid: 2012R1A1A2021749 |
| GroupedDBID | 5-W 8JR 8XY AAYXX ADBBV ADRAZ ALMA_UNASSIGNED_HOLDINGS AOIJS CITATION EF. HYE KQ8 M48 OK1 PGMZT RPM NPM 7X8 5PM ACYCR M~E |
| ID | FETCH-LOGICAL-c3404-2eadb4b530aaf2d6406f3e7f506b0e968ca6540c4b38d62d638b30521bc788cd3 |
| IEDL.DBID | M48 |
| ISSN | 1226-2560 |
| IngestDate | Tue Nov 21 21:42:25 EST 2023 Thu Aug 21 14:19:36 EDT 2025 Fri Jul 11 16:39:02 EDT 2025 Thu Apr 03 07:04:37 EDT 2025 Tue Jul 01 02:48:16 EDT 2025 Thu Apr 24 23:01:45 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Keywords | down syndrome neuritogenesis cytoskeletal proteins synaptogenesis Dyrk1A |
| Language | English |
| License | This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c3404-2eadb4b530aaf2d6406f3e7f506b0e968ca6540c4b38d62d638b30521bc788cd3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 G704-SER000009883.2013.22.4.011 |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.5607/en.2013.22.4.244 |
| PMID | 24465139 |
| PQID | 1540110231 |
| PQPubID | 23479 |
| PageCount | 5 |
| ParticipantIDs | nrf_kci_oai_kci_go_kr_ARTI_427348 pubmedcentral_primary_oai_pubmedcentral_nih_gov_3897685 proquest_miscellaneous_1540110231 pubmed_primary_24465139 crossref_citationtrail_10_5607_en_2013_22_4_244 crossref_primary_10_5607_en_2013_22_4_244 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 20131201 |
| PublicationDateYYYYMMDD | 2013-12-01 |
| PublicationDate_xml | – month: 12 year: 2013 text: 20131201 day: 1 |
| PublicationDecade | 2010 |
| PublicationPlace | Korea (South) |
| PublicationPlace_xml | – name: Korea (South) |
| PublicationTitle | Experimental neurobiology |
| PublicationTitleAlternate | Exp Neurobiol |
| PublicationYear | 2013 |
| Publisher | The Korean Society for Brain and Neural Science 한국뇌신경과학회 |
| Publisher_xml | – name: The Korean Society for Brain and Neural Science – name: 한국뇌신경과학회 |
| References | Teller (10.5607/en.2013.22.4.244_ref30) 1996; 2 Wisniewski (10.5607/en.2013.22.4.244_ref12) 1984; 311 Scales (10.5607/en.2013.22.4.244_ref24) 2009; 122 Woods (10.5607/en.2013.22.4.244_ref32) 2001; 355 Suetsugu (10.5607/en.2013.22.4.244_ref19) 1980; 50 Liu (10.5607/en.2013.22.4.244_ref27) 2009; 10 McCormick (10.5607/en.2013.22.4.244_ref6) 1989; 5 Bain (10.5607/en.2013.22.4.244_ref39) 2007; 408 Park (10.5607/en.2013.22.4.244_ref28) 2012; 125 Kelly (10.5607/en.2013.22.4.244_ref21) 2005; 16 Wegiel (10.5607/en.2013.22.4.244_ref35) 2008; 116 Park (10.5607/en.2013.22.4.244_ref9) 2009; 42 Wisniewski (10.5607/en.2013.22.4.244_ref16) 1985; 17 Göckler (10.5607/en.2013.22.4.244_ref25) 2009; 276 Frost (10.5607/en.2013.22.4.244_ref40) 2011; 6 Martinez de Lagran (10.5607/en.2013.22.4.244_ref23) 2012; 22 Yin (10.5607/en.2013.22.4.244_ref36) 2012; 287 Park (10.5607/en.2013.22.4.244_ref11) 2009; 66 Contestabile (10.5607/en.2013.22.4.244_ref14) 2007; 17 Guedj (10.5607/en.2013.22.4.244_ref38) 2009; 4 Mann (10.5607/en.2013.22.4.244_ref31) 1988; 13 Mann (10.5607/en.2013.22.4.244_ref13) 1987; 80 Kimura (10.5607/en.2013.22.4.244_ref15) 2005; 39 Lejeune (10.5607/en.2013.22.4.244_ref5) 1959; 248 Park (10.5607/en.2013.22.4.244_ref22) 2007; 36 Himpel (10.5607/en.2013.22.4.244_ref10) 2000; 275 Antonarakis (10.5607/en.2013.22.4.244_ref2) 2004; 5 Delabar (10.5607/en.2013.22.4.244_ref8) 1993; 1 Wisniewski (10.5607/en.2013.22.4.244_ref17) 1985; 35 Ferrer (10.5607/en.2013.22.4.244_ref18) 1990; 79 Tatebe (10.5607/en.2013.22.4.244_ref26) 2008; 18 Haas (10.5607/en.2013.22.4.244_ref20) 2013; 8 Roizen (10.5607/en.2013.22.4.244_ref3) 2003; 361 Ryoo (10.5607/en.2013.22.4.244_ref33) 2007; 282 Dowjat (10.5607/en.2013.22.4.244_ref29) 2012; 71 Xie (10.5607/en.2013.22.4.244_ref37) 2008; 33 Korenberg (10.5607/en.2013.22.4.244_ref7) 1990; 47 Liu (10.5607/en.2013.22.4.244_ref34) 2008; 22 Down (10.5607/en.2013.22.4.244_ref1) 1995; 33 Hasle (10.5607/en.2013.22.4.244_ref4) 2000; 355 19796173 - FEBS J. 2009 Nov;276(21):6324-37 11311121 - Biochem J. 2001 May 1;355(Pt 3):609-15 8055322 - Eur J Hum Genet. 1993;1(2):114-24 22250195 - J Cell Sci. 2012 Jan 1;125(Pt 1):67-80 23147510 - J Neuropathol Exp Neurol. 2012 Dec;71(12):1100-12 15993336 - Free Radic Biol Med. 2005 Aug 1;39(3):374-80 13639368 - C R Hebd Seances Acad Sci. 1959 Mar 16;248(11):1721-2 15917294 - Mol Biol Cell. 2005 Aug;16(8):3562-73 19549690 - J Cell Sci. 2009 Jul 15;122(Pt 14):2424-35 18696092 - Acta Neuropathol. 2008 Oct;116(4):391-407 24205261 - PLoS One. 2013 Oct 30;8(10):e78561 22215728 - Cereb Cortex. 2012 Dec;22(12):2867-77 3159974 - Neurology. 1985 Jul;35(7):957-61 17906291 - J Biol Chem. 2007 Nov 30;282(48):34850-7 22767602 - J Biol Chem. 2012 Aug 31;287(36):30497-506 2143053 - Am J Hum Genet. 1990 Aug;47(2):236-46 10644696 - J Biol Chem. 2000 Jan 28;275(4):2431-8 17943438 - Neurochem Res. 2008 May;33(5):776-83 10675114 - Lancet. 2000 Jan 15;355(9199):165-9 19242551 - PLoS One. 2009;4(2):e4606 2956368 - J Neurol Sci. 1987 Aug;80(1):79-89 15510164 - Nat Rev Genet. 2004 Oct;5(10):725-38 6237262 - N Engl J Med. 1984 Nov 1;311(18):1187-8 17850214 - Biochem J. 2007 Dec 15;408(3):297-315 18328707 - Curr Biol. 2008 Mar 11;18(5):322-30 3158266 - Ann Neurol. 1985 Mar;17(3):278-82 2971602 - Histopathology. 1988 Aug;13(2):125-37 19265526 - Genome Biol. 2009;10(3):R26 19685005 - Cell Mol Life Sci. 2009 Oct;66(20):3235-40 6447982 - Acta Neuropathol. 1980;50(3):207-10 18509201 - FASEB J. 2008 Sep;22(9):3224-33 2141748 - Acta Neuropathol. 1990;79(6):680-5 21573099 - PLoS One. 2011 May 06;6(5):e19264 8564851 - Nat Med. 1996 Jan;2(1):93-5 7707939 - Ment Retard. 1995 Feb;33(1):54-6 17720532 - Mol Cell Neurosci. 2007 Oct;36(2):270-9 2529205 - Genomics. 1989 Aug;5(2):325-31 19192387 - BMB Rep. 2009 Jan 31;42(1):6-15 17546680 - Hippocampus. 2007;17(8):665-78 12699967 - Lancet. 2003 Apr 12;361(9365):1281-9 |
| References_xml | – volume: 5 start-page: 325 year: 1989 ident: 10.5607/en.2013.22.4.244_ref6 publication-title: Genomics doi: 10.1016/0888-7543(89)90065-7 – volume: 66 start-page: 3235 year: 2009 ident: 10.5607/en.2013.22.4.244_ref11 publication-title: Cell Mol Life Sci doi: 10.1007/s00018-009-0123-2 – volume: 361 start-page: 1281 year: 2003 ident: 10.5607/en.2013.22.4.244_ref3 publication-title: Lancet doi: 10.1016/S0140-6736(03)12987-X – volume: 2 start-page: 93 year: 1996 ident: 10.5607/en.2013.22.4.244_ref30 publication-title: Nat Med doi: 10.1038/nm0196-93 – volume: 287 start-page: 30497 year: 2012 ident: 10.5607/en.2013.22.4.244_ref36 publication-title: J Biol Chem doi: 10.1074/jbc.M112.355412 – volume: 116 start-page: 391 year: 2008 ident: 10.5607/en.2013.22.4.244_ref35 publication-title: Acta Neuropathol doi: 10.1007/s00401-008-0419-6 – volume: 42 start-page: 6 year: 2009 ident: 10.5607/en.2013.22.4.244_ref9 publication-title: BMB Rep doi: 10.5483/BMBRep.2009.42.1.006 – volume: 71 start-page: 1100 year: 2012 ident: 10.5607/en.2013.22.4.244_ref29 publication-title: J Neuropathol Exp Neurol doi: 10.1097/NEN.0b013e31827733c8 – volume: 36 start-page: 270 year: 2007 ident: 10.5607/en.2013.22.4.244_ref22 publication-title: Mol Cell Neurosci doi: 10.1016/j.mcn.2007.07.007 – volume: 1 start-page: 114 year: 1993 ident: 10.5607/en.2013.22.4.244_ref8 publication-title: Eur J Hum Genet doi: 10.1159/000472398 – volume: 408 start-page: 297 year: 2007 ident: 10.5607/en.2013.22.4.244_ref39 publication-title: Biochem J doi: 10.1042/BJ20070797 – volume: 5 start-page: 725 year: 2004 ident: 10.5607/en.2013.22.4.244_ref2 publication-title: Nat Rev Genet doi: 10.1038/nrg1448 – volume: 39 start-page: 374 year: 2005 ident: 10.5607/en.2013.22.4.244_ref15 publication-title: Free Radic Biol Med doi: 10.1016/j.freeradbiomed.2005.03.023 – volume: 4 start-page: e4606 year: 2009 ident: 10.5607/en.2013.22.4.244_ref38 publication-title: PLoS One doi: 10.1371/journal.pone.0004606 – volume: 80 start-page: 79 year: 1987 ident: 10.5607/en.2013.22.4.244_ref13 publication-title: J Neurol Sci doi: 10.1016/0022-510X(87)90223-1 – volume: 8 start-page: e78561 year: 2013 ident: 10.5607/en.2013.22.4.244_ref20 publication-title: PLoS One doi: 10.1371/journal.pone.0078561 – volume: 33 start-page: 776 year: 2008 ident: 10.5607/en.2013.22.4.244_ref37 publication-title: Neurochem Res doi: 10.1007/s11064-007-9494-7 – volume: 79 start-page: 680 year: 1990 ident: 10.5607/en.2013.22.4.244_ref18 publication-title: Acta Neuropathol doi: 10.1007/BF00294247 – volume: 50 start-page: 207 year: 1980 ident: 10.5607/en.2013.22.4.244_ref19 publication-title: Acta Neuropathol doi: 10.1007/BF00688755 – volume: 35 start-page: 957 year: 1985 ident: 10.5607/en.2013.22.4.244_ref17 publication-title: Neurology doi: 10.1212/WNL.35.7.957 – volume: 17 start-page: 665 year: 2007 ident: 10.5607/en.2013.22.4.244_ref14 publication-title: Hippocampus doi: 10.1002/hipo.20308 – volume: 355 start-page: 609 year: 2001 ident: 10.5607/en.2013.22.4.244_ref32 publication-title: Biochem J doi: 10.1042/bj3550609 – volume: 282 start-page: 34850 year: 2007 ident: 10.5607/en.2013.22.4.244_ref33 publication-title: J Biol Chem doi: 10.1074/jbc.M707358200 – volume: 33 start-page: 54 year: 1995 ident: 10.5607/en.2013.22.4.244_ref1 publication-title: Ment Retard – volume: 47 start-page: 236 year: 1990 ident: 10.5607/en.2013.22.4.244_ref7 publication-title: Am J Hum Genet – volume: 275 start-page: 2431 year: 2000 ident: 10.5607/en.2013.22.4.244_ref10 publication-title: J Biol Chem doi: 10.1074/jbc.275.4.2431 – volume: 355 start-page: 165 year: 2000 ident: 10.5607/en.2013.22.4.244_ref4 publication-title: Lancet doi: 10.1016/S0140-6736(99)05264-2 – volume: 122 start-page: 2424 year: 2009 ident: 10.5607/en.2013.22.4.244_ref24 publication-title: J Cell Sci doi: 10.1242/jcs.040162 – volume: 16 start-page: 3562 year: 2005 ident: 10.5607/en.2013.22.4.244_ref21 publication-title: Mol Biol Cell doi: 10.1091/mbc.E04-12-1085 – volume: 6 start-page: e19264 year: 2011 ident: 10.5607/en.2013.22.4.244_ref40 publication-title: PLoS One doi: 10.1371/journal.pone.0019264 – volume: 18 start-page: 322 year: 2008 ident: 10.5607/en.2013.22.4.244_ref26 publication-title: Curr Biol doi: 10.1016/j.cub.2008.02.005 – volume: 17 start-page: 278 year: 1985 ident: 10.5607/en.2013.22.4.244_ref16 publication-title: Ann Neurol doi: 10.1002/ana.410170310 – volume: 276 start-page: 6324 year: 2009 ident: 10.5607/en.2013.22.4.244_ref25 publication-title: FEBS J doi: 10.1111/j.1742-4658.2009.07346.x – volume: 22 start-page: 2867 year: 2012 ident: 10.5607/en.2013.22.4.244_ref23 publication-title: Cereb Cortex doi: 10.1093/cercor/bhr362 – volume: 13 start-page: 125 year: 1988 ident: 10.5607/en.2013.22.4.244_ref31 publication-title: Histopathology doi: 10.1111/j.1365-2559.1988.tb02018.x – volume: 248 start-page: 1721 year: 1959 ident: 10.5607/en.2013.22.4.244_ref5 publication-title: C R Hebd Seances Acad Sci – volume: 10 start-page: R26 year: 2009 ident: 10.5607/en.2013.22.4.244_ref27 publication-title: Genome Biol doi: 10.1186/gb-2009-10-3-r26 – volume: 125 start-page: 67 year: 2012 ident: 10.5607/en.2013.22.4.244_ref28 publication-title: J Cell Sci doi: 10.1242/jcs.086124 – volume: 311 start-page: 1187 year: 1984 ident: 10.5607/en.2013.22.4.244_ref12 publication-title: N Engl J Med – volume: 22 start-page: 3224 year: 2008 ident: 10.5607/en.2013.22.4.244_ref34 publication-title: FASEB J doi: 10.1096/fj.07-104539 – reference: 18696092 - Acta Neuropathol. 2008 Oct;116(4):391-407 – reference: 17546680 - Hippocampus. 2007;17(8):665-78 – reference: 17850214 - Biochem J. 2007 Dec 15;408(3):297-315 – reference: 19242551 - PLoS One. 2009;4(2):e4606 – reference: 2141748 - Acta Neuropathol. 1990;79(6):680-5 – reference: 10644696 - J Biol Chem. 2000 Jan 28;275(4):2431-8 – reference: 7707939 - Ment Retard. 1995 Feb;33(1):54-6 – reference: 8055322 - Eur J Hum Genet. 1993;1(2):114-24 – reference: 19796173 - FEBS J. 2009 Nov;276(21):6324-37 – reference: 22767602 - J Biol Chem. 2012 Aug 31;287(36):30497-506 – reference: 13639368 - C R Hebd Seances Acad Sci. 1959 Mar 16;248(11):1721-2 – reference: 2143053 - Am J Hum Genet. 1990 Aug;47(2):236-46 – reference: 6237262 - N Engl J Med. 1984 Nov 1;311(18):1187-8 – reference: 3159974 - Neurology. 1985 Jul;35(7):957-61 – reference: 10675114 - Lancet. 2000 Jan 15;355(9199):165-9 – reference: 15917294 - Mol Biol Cell. 2005 Aug;16(8):3562-73 – reference: 2971602 - Histopathology. 1988 Aug;13(2):125-37 – reference: 23147510 - J Neuropathol Exp Neurol. 2012 Dec;71(12):1100-12 – reference: 15510164 - Nat Rev Genet. 2004 Oct;5(10):725-38 – reference: 12699967 - Lancet. 2003 Apr 12;361(9365):1281-9 – reference: 18509201 - FASEB J. 2008 Sep;22(9):3224-33 – reference: 11311121 - Biochem J. 2001 May 1;355(Pt 3):609-15 – reference: 17720532 - Mol Cell Neurosci. 2007 Oct;36(2):270-9 – reference: 17906291 - J Biol Chem. 2007 Nov 30;282(48):34850-7 – reference: 22215728 - Cereb Cortex. 2012 Dec;22(12):2867-77 – reference: 24205261 - PLoS One. 2013 Oct 30;8(10):e78561 – reference: 8564851 - Nat Med. 1996 Jan;2(1):93-5 – reference: 2956368 - J Neurol Sci. 1987 Aug;80(1):79-89 – reference: 22250195 - J Cell Sci. 2012 Jan 1;125(Pt 1):67-80 – reference: 6447982 - Acta Neuropathol. 1980;50(3):207-10 – reference: 15993336 - Free Radic Biol Med. 2005 Aug 1;39(3):374-80 – reference: 3158266 - Ann Neurol. 1985 Mar;17(3):278-82 – reference: 2529205 - Genomics. 1989 Aug;5(2):325-31 – reference: 19685005 - Cell Mol Life Sci. 2009 Oct;66(20):3235-40 – reference: 19549690 - J Cell Sci. 2009 Jul 15;122(Pt 14):2424-35 – reference: 17943438 - Neurochem Res. 2008 May;33(5):776-83 – reference: 19192387 - BMB Rep. 2009 Jan 31;42(1):6-15 – reference: 21573099 - PLoS One. 2011 May 06;6(5):e19264 – reference: 19265526 - Genome Biol. 2009;10(3):R26 – reference: 18328707 - Curr Biol. 2008 Mar 11;18(5):322-30 |
| SSID | ssj0000559516 |
| Score | 1.8567287 |
| SecondaryResourceType | review_article |
| Snippet | Down syndrome (DS) is one of the most common genetic disorders accompanying with mental retardation, cognitive impairment, and deficits in learning and memory.... Down syndrome (DS) is one of the most common genetic disorders accompanying with mental retardation, cognitive impairment,and deficits in learning and memory.... |
| SourceID | nrf pubmedcentral proquest pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | 244 |
| SubjectTerms | Review 뇌과학 |
| Title | New Perspectives of Dyrk1A Role in Neurogenesis and Neuropathologic Features of Down Syndrome |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/24465139 https://www.proquest.com/docview/1540110231 https://pubmed.ncbi.nlm.nih.gov/PMC3897685 https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART001844395 |
| Volume | 22 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| ispartofPNX | Experimental Neurobiology, 2013, 22(4), , pp.244-248 |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Nb9QwELVouXBBQPlYPiojISQOSRPbcdITWgFVQSpCwEq9ICt2nLLaxWmzXYn997xJstsWrThwipTYieKxZ97zxxvGXulSlxkoV5Q7cFXlUx8VwB1R7W3p4ZR93iWbOPmsjyfq02l2enU8emjAxVZqR_mkJu08_n2xeosBD_waI17nB550TFMZCxGrGOFqh91GXNJExU4GsN8rfWeAE91xI2COiGJ9v2659SWkEkxiYimlEb8WsnZCW29Do39vqrwWpY7usbsDvOTjvj_cZ7d8eMD2xgHU-teKv-bdhs9uJn2P_YCD41-uDlsueFPz96t2lo7512bu-TTwTrvjjPzhdMHLUPU3KI1x7zQ5QchlO9QFo-ffBgmEh2xy9OH7u-NoyLYQOakSFQn0KatsJpOyrEWlEelr6fM6S7RN_KEuXKkB75yysqg0CsjCSjr6ax1otKvkI7YbmuCfMK6kqlPtcngMoTJfgDVV1gIZHwqbOCFH7GDdoMYNUuSUEWNuQEnIGhiyhqxhhDDKwA4j9mZT47yX4fhH2ZewkZm5qSHtbLqeNWbWGjCEj0Z1ej4os7agwXiiRZIy-Ga5MICUBIkAe0fscW_RzRfXHWLE8hu23hSg7918EqY_O81u4EIQu-zpf9d8xu7QX_Y7aZ6z3ct26V8AD13a_a6b73cTVX8ApuwILQ |
| linkProvider | Scholars Portal |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=New+Perspectives+of+Dyrk1A+Role+in+Neurogenesis+and+Neuropathologic+Features+of+Down+Syndrome&rft.jtitle=Experimental+neurobiology&rft.au=Park%2C+Joongkyu&rft.au=Chung%2C+Kwang+Chul&rft.date=2013-12-01&rft.pub=The+Korean+Society+for+Brain+and+Neural+Science&rft.issn=1226-2560&rft.eissn=2093-8144&rft.volume=22&rft.issue=4&rft.spage=244&rft.epage=248&rft_id=info:doi/10.5607%2Fen.2013.22.4.244&rft_id=info%3Apmid%2F24465139&rft.externalDocID=PMC3897685 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1226-2560&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1226-2560&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1226-2560&client=summon |