Surface engineering of lipid nanoparticles: targeted nucleic acid delivery and beyond

• Published in: Biophysics reports Vol. 9; no. 5; pp. 255 - 278
• Main Authors: Lin, Yi, Cheng, Qiang, Wei, Tuo
• Format: Journal Article
• Language: English
• Published: China Institute of Biophysics 31.10.2023; Biophysics Reports Editorial Office
• Subjects: Acids; Conjugation; COVID-19 vaccines; Drug delivery; Engineering; Invited Review; Ligands; Lipids; mRNA; Nanoparticles; Nucleic acids; siRNA; Nucleic acid delivery; Surface engineering; Targeted delivery; Lipid nanoparticles

Harnessing surface engineering strategies to functionalize nucleic acid-lipid nanoparticles (LNPs) for improved performance has been a hot research topic since the approval of the first siRNA drug, patisiran, and two mRNA-based COVID-19 vaccines, BNT162b2 and mRNA-1273. Currently, efforts have been...