Effect of lycopene in the treatment of periodontal disease: a clinical study
Several epidemiologic studies have suggested a role of tomato products in decreasing the risk of the development of diseases related to oxidative stress (cancer and other chronic diseases). Oxidative stress may result in periodontal tissue damage either directly or indirectly. Lycopene, a powerful a...
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Published in | The journal of contemporary dental practice Vol. 14; no. 6; pp. 1054 - 1059 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
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India
01.11.2013
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Abstract | Several epidemiologic studies have suggested a role of tomato products in decreasing the risk of the development of diseases related to oxidative stress (cancer and other chronic diseases). Oxidative stress may result in periodontal tissue damage either directly or indirectly. Lycopene, a powerful antioxidant and the main carotenoid in tomato products possesses the greatest quenching ability of singlet oxygen among the various carotenoids and is effective in protecting blood lymphocytes from NOO-radical damage. Hence, the aim of the present study is to compare the effect of systemically administered lycopene as an adjunct to scaling and root planing in patients with gingivitis and periodontitis.
Twenty systemically healthy patients were involved in a randomized, double-blind, parallel study and based on their clinical signs were divided into two groups of mild to moderate periodontitis (A) and moderate gingivitis (B). The subjects under the groups A and B were randomly distributed between the two treatment groups: test group (n = 5), 4 mg lycopene/day for 2 weeks with oral prophylaxis (full mouth scaling and root planing (SRP) completed within 24 hours) and controls (n = 5), receiving only oral prophylaxis. Pre- and post-therapeutic periodontal parameters were evaluated.
In group A, statistically significant improvement in CAL was reported in test group as compared to control group. In group B, the difference between pretreatment and post-treatment bleeding on probing scores was found to be statistically non-significant in both groups.
Results show that lycopene is a promising treatment modality as an adjunct to full mouth SRP of the oral cavity in patients with moderate periodontal disease.
Modulation of the free radical production seems to be essential for the inhibition of tissue destruction, and treatment with antioxidants, like lycopene, which is the most potent among them will block the production of free ROS or its effects might prove to be therapeutically valuable. |
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AbstractList | Several epidemiologic studies have suggested a role of tomato products in decreasing the risk of the development of diseases related to oxidative stress (cancer and other chronic diseases). Oxidative stress may result in periodontal tissue damage either directly or indirectly. Lycopene, a powerful antioxidant and the main carotenoid in tomato products possesses the greatest quenching ability of singlet oxygen among the various carotenoids and is effective in protecting blood lymphocytes from NOO-radical damage. Hence, the aim of the present study is to compare the effect of systemically administered lycopene as an adjunct to scaling and root planing in patients with gingivitis and periodontitis.
Twenty systemically healthy patients were involved in a randomized, double-blind, parallel study and based on their clinical signs were divided into two groups of mild to moderate periodontitis (A) and moderate gingivitis (B). The subjects under the groups A and B were randomly distributed between the two treatment groups: test group (n = 5), 4 mg lycopene/day for 2 weeks with oral prophylaxis (full mouth scaling and root planing (SRP) completed within 24 hours) and controls (n = 5), receiving only oral prophylaxis. Pre- and post-therapeutic periodontal parameters were evaluated.
In group A, statistically significant improvement in CAL was reported in test group as compared to control group. In group B, the difference between pretreatment and post-treatment bleeding on probing scores was found to be statistically non-significant in both groups.
Results show that lycopene is a promising treatment modality as an adjunct to full mouth SRP of the oral cavity in patients with moderate periodontal disease.
Modulation of the free radical production seems to be essential for the inhibition of tissue destruction, and treatment with antioxidants, like lycopene, which is the most potent among them will block the production of free ROS or its effects might prove to be therapeutically valuable. PURPOSESeveral epidemiologic studies have suggested a role of tomato products in decreasing the risk of the development of diseases related to oxidative stress (cancer and other chronic diseases). Oxidative stress may result in periodontal tissue damage either directly or indirectly. Lycopene, a powerful antioxidant and the main carotenoid in tomato products possesses the greatest quenching ability of singlet oxygen among the various carotenoids and is effective in protecting blood lymphocytes from NOO-radical damage. Hence, the aim of the present study is to compare the effect of systemically administered lycopene as an adjunct to scaling and root planing in patients with gingivitis and periodontitis. MATERIALS AND METHODSTwenty systemically healthy patients were involved in a randomized, double-blind, parallel study and based on their clinical signs were divided into two groups of mild to moderate periodontitis (A) and moderate gingivitis (B). The subjects under the groups A and B were randomly distributed between the two treatment groups: test group (n = 5), 4 mg lycopene/day for 2 weeks with oral prophylaxis (full mouth scaling and root planing (SRP) completed within 24 hours) and controls (n = 5), receiving only oral prophylaxis. Pre- and post-therapeutic periodontal parameters were evaluated. RESULTSIn group A, statistically significant improvement in CAL was reported in test group as compared to control group. In group B, the difference between pretreatment and post-treatment bleeding on probing scores was found to be statistically non-significant in both groups. CONCLUSIONResults show that lycopene is a promising treatment modality as an adjunct to full mouth SRP of the oral cavity in patients with moderate periodontal disease. CLINICAL SIGNIFICANCEModulation of the free radical production seems to be essential for the inhibition of tissue destruction, and treatment with antioxidants, like lycopene, which is the most potent among them will block the production of free ROS or its effects might prove to be therapeutically valuable. ABSTRACT Purpose Several epidemiologic studies have suggested a role of tomato products in decreasing the risk of the development of diseases related to oxidative stress (cancer and other chronic diseases). Oxidative stress may result in periodontal tissue damage either directly or indirectly. Lycopene, a powerful antioxidant and the main carotenoid in tomato products possesses the greatest quenching ability of singlet oxygen among the various carotenoids and is effective in protecting blood lymphocytes from NOO-radical damage. Hence, the aim of the present study is to compare the effect of systemically administered lycopene as an adjunct to scaling and root planing in patients with gingivitis and periodontitis. Materials and methods Twenty systemically healthy patients were involved in a randomized, double-blind, parallel study and based on their clinical signs were divided into two groups of mild to moderate periodontitis (A) and moderate gingivitis (B). The subjects under the groups A and B were randomly distributed between the two treatment groups: test group (n = 5), 4 mg lycopene/day for 2 weeks with oral prophylaxis (full mouth scaling and root planing (SRP) completed within 24 hours) and controls (n = 5), receiving only oral prophylaxis. Pre- and post-therapeutic periodontal parameters were evaluated. Results In group A, statistically significant improvement in CAL was reported in test group as compared to control group. In group B, the difference between pretreatment and post-treatment bleeding on probing scores was found to be statistically non-significant in both groups. Conclusion Results show that lycopene is a promising treatment modality as an adjunct to full mouth SRP of the oral cavity in patients with moderate periodontal disease. Clinical significance Modulation of the free radical production seems to be essential for the inhibition of tissue destruction, and treatment with antioxidants, like lycopene, which is the most potent among them will block the production of free ROS or its effects might prove to be therapeutically valuable. How to cite this article Belludi SA, Verma S, Banthia R, Bhusari P, Parwani S, Kedia S, Saiprasad SV. Effect of Lycopene in the Treatment of Periodontal Disease: A Clinical Study. J Contemp Dent Pract 2013;14(6):1054-1059. |
Author | Bhusari, Prashanth Belludi, Sphoorthi Anup Parwani, Simran Verma, Shiras Banthia, Ruchi Kedia, Sameer Saiprasad, S V |
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References | Chandra RV, Prabhuji ML, Roopa DA, et al. (ref21) 2007; 5 Medzhitov R. (ref11) 2008; 454 Bohm F, Tinkler JH, Truscott TG. (ref29) 1995; 1 ref=26 Adriana SR, Patricia RS, Tarcilia A, da Silva, Ricardo AM. (ref3) 2010; 1 Riccioni G, Mancini B, Di Ilio E, Bucciarelli T, D'Orazio N. (ref7) 2008; 12 ref=24 ref=22 ref=20 Firatli E, Unal T, Onan U, Sandalli P. (ref25) 1994; 21 Preshaw PM. (ref33) 2009; 36 Chapple ILC, Matthews JP. (ref17) 2007; 43 Singh M, et al. (ref31) 2004; 40 ref=28 ref=6 Goultschin J, Levy H. (ref19) 1986; 57 ref=8 Wood N, Johnson RB. (ref35) 2004; 31 ref=2 Levy J, Sharoni Y. (ref37) 2004; 62 ref=4 ref=30 Babior BM. (ref15) 2000; 109 ref=16 ref=38 ref=14 ref=36 ref=12 Di Mascio P, Kaiser S, Sies H. (ref27) 1989; 274 ref=34 Linden GJ, Mc Clean KM, Woodside JV, et al. (ref9) 2009; 36 ref=10 ref=32 Rao AV, Agarwal S. (ref5) 2000; 19 Painter FM. (ref1) 2003; 8 ref=18 Brock GR, Butterworth CJ, Mathews JP, Chapple ILC. (ref13) 2004; 31 Di Paola R, Mazzon E, Zito D, et al. (ref23) 2005; 32 |
References_xml | – ident: ref=4 doi: 10.1155/2010/186018 – volume: 274: start-page: 532 year: 1989 ident: ref27 publication-title: Arch Biochem Biophys doi: 10.1016/0003-9861(89)90467-0 contributor: fullname: Di Mascio P, Kaiser S, Sies H. – volume: 19: start-page: 563 year: 2000 ident: ref5 publication-title: Journal of the American College of Nutrition doi: 10.1080/07315724.2000.10718953 contributor: fullname: Rao AV, Agarwal S. – volume: 62: start-page: 49 year: 2004 ident: ref37 publication-title: Herbal Gram contributor: fullname: Levy J, Sharoni Y. – volume: 454: start-page: 428 year: 2008 ident: ref11 publication-title: Nature doi: 10.1038/nature07201 contributor: fullname: Medzhitov R. – ident: ref=24 doi: 10.1111/j.1600-051X.2005.00818.x – volume: 31: start-page: 574 year: 2004 ident: ref35 publication-title: J Clin Periodontol doi: 10.1111/j.1600-051X.2004.00531.x contributor: fullname: Wood N, Johnson RB. – ident: ref=18 doi: 10.1111/j.1600-0757.2006.00178.x – ident: ref=28 doi: 10.1016/0003-9861(89)90467-0 – volume: 36: start-page: 1 year: 2009 ident: ref33 publication-title: J Clin Periodontol doi: 10.1111/j.1600-051X.2008.01320.x contributor: fullname: Preshaw PM. – ident: ref=34 doi: 10.1111/j.1600-051X.2008.01320.x – ident: ref=14 doi: 10.1111/j.1600-051X.2004.00509.x – volume: 1: start-page: 98 year: 1995 ident: ref29 publication-title: Nat Med doi: 10.1038/nm0295-98 contributor: fullname: Bohm F, Tinkler JH, Truscott TG. – ident: ref=22 – ident: ref=30 doi: 10.1038/nm0295-98 – volume: 32: start-page: 1062 year: 2005 ident: ref23 publication-title: J Clin Periodontol doi: 10.1111/j.1600-051X.2005.00818.x contributor: fullname: Di Paola R, Mazzon E, Zito D, et al. – ident: ref=38 – ident: ref=20 doi: 10.1902/jop.1986.57.7.422 – ident: ref=6 doi: 10.1080/07315724.2000.10718953 – volume: 21: start-page: 680 year: 1994 ident: ref25 publication-title: J Clin Periodontol doi: 10.1111/j.1600-051X.1994.tb00786.x contributor: fullname: Firatli E, Unal T, Onan U, Sandalli P. – ident: ref=2 – volume: 31: start-page: 515 year: 2004 ident: ref13 publication-title: J Clin Periodontol doi: 10.1111/j.1600-051X.2004.00509.x contributor: fullname: Brock GR, Butterworth CJ, Mathews JP, Chapple ILC. – ident: ref=12 doi: 10.1038/nature07201 – volume: 1: start-page: 1 year: 2010 ident: ref3 publication-title: International Journal of Dentistry contributor: fullname: Adriana SR, Patricia RS, Tarcilia A, da Silva, Ricardo AM. – ident: ref=8 – volume: 8: start-page: 336 year: 2003 ident: ref1 publication-title: Alternative Medicine Review contributor: fullname: Painter FM. – volume: 12: start-page: 183 year: 2008 ident: ref7 publication-title: European Review for Medical and Pharmacological Sciences contributor: fullname: Riccioni G, Mancini B, Di Ilio E, Bucciarelli T, D'Orazio N. – volume: 57: start-page: 422 year: 1986 ident: ref19 publication-title: J Periodontol doi: 10.1902/jop.1986.57.7.422 contributor: fullname: Goultschin J, Levy H. – volume: 5: start-page: 327 year: 2007 ident: ref21 publication-title: Oral Health Prev Dent contributor: fullname: Chandra RV, Prabhuji ML, Roopa DA, et al. – volume: 40: start-page: 591 year: 2004 ident: ref31 publication-title: Oral Oncology doi: 10.1016/j.oraloncology.2003.12.011 contributor: fullname: Singh M, et al. – ident: ref=36 doi: 10.1111/j.1600-051X.2004.00531.x – ident: ref=26 doi: 10.1111/j.1600-051X.1994.tb00786.x – volume: 36: start-page: 843 year: 2009 ident: ref9 publication-title: J Clin Periodontol doi: 10.1111/j.1600-051X.2009.01468.x contributor: fullname: Linden GJ, Mc Clean KM, Woodside JV, et al. – ident: ref=32 doi: 10.1016/j.oraloncology.2003.12.011 – volume: 43: start-page: 160 year: 2007 ident: ref17 publication-title: Periodontol 2000, doi: 10.1111/j.1600-0757.2006.00178.x contributor: fullname: Chapple ILC, Matthews JP. – ident: ref=10 doi: 10.1111/j.1600-051X.2009.01468.x – volume: 109: start-page: 33 year: 2000 ident: ref15 publication-title: American Journal of Medicine doi: 10.1016/S0002-9343(00)00481-2 contributor: fullname: Babior BM. – ident: ref=16 doi: 10.1016/S0002-9343(00)00481-2 |
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Snippet | Several epidemiologic studies have suggested a role of tomato products in decreasing the risk of the development of diseases related to oxidative stress... ABSTRACT Purpose Several epidemiologic studies have suggested a role of tomato products in decreasing the risk of the development of diseases related to... PURPOSESeveral epidemiologic studies have suggested a role of tomato products in decreasing the risk of the development of diseases related to oxidative stress... |
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SubjectTerms | Adult Antioxidants - therapeutic use Carotenoids - therapeutic use Combined Modality Therapy Dental Scaling - methods Dentistry Double-Blind Method Free Radicals - antagonists & inhibitors Gingival Hemorrhage - therapy Gingivitis - therapy Humans Periodontal Attachment Loss - therapy Periodontal Index Periodontal Pocket - therapy Periodontitis - therapy Reactive Oxygen Species - antagonists & inhibitors Root Planing - methods |
Title | Effect of lycopene in the treatment of periodontal disease: a clinical study |
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