Bedtime dosing of glyburide and the treatment of type II diabetes mellitus

• Published in: The American journal of the medical sciences Vol. 308; no. 4; p. 234
• Main Authors: Hennessey, J V, Bustamante, M A, Teter, M L, Markert, R J, McDonald, S D
• Format: Journal Article
• Language: English
• Published: United States 01.10.1994
• Subjects: Adolescent; Adult; Aged; Blood Glucose - metabolism; Circadian Rhythm; Diabetes Mellitus, Type 2 - drug therapy; Double-Blind Method; Fasting; Female; Glyburide - administration & dosage; Glyburide - therapeutic use; Glycated Hemoglobin A - metabolism; Humans; Male; Middle Aged; Placebos

Suppression of nocturnal hepatic glucose production is key in the treatment of noninsulin-dependent diabetes mellitus (NIDDM). In this article, the authors compare the effectiveness of dosing glyburide at bedtime versus in the morning on glycemic control in patients with NIDDM under suboptimal contr...