Association of polymorphism in glutamate-cysteine ligase catalytic subunit gene with schizophrenia: A case-control study in a Tunisian population
Glutathione (GSH) is a key regulator of oxidative balance in all mammals, especially in the central nervous system. The first step of glutathione synthesis is catalysed by glutamate cysteine ligase (GCL), which is composed of catalytic and modifier subunits (GCLC and GCLM, respectively). The purpose...
Saved in:
| Published in | Gene reports Vol. 4; pp. 249 - 252 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Elsevier Inc
01.09.2016
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 2452-0144 2452-0144 |
| DOI | 10.1016/j.genrep.2016.07.007 |
Cover
Loading…
| Abstract | Glutathione (GSH) is a key regulator of oxidative balance in all mammals, especially in the central nervous system. The first step of glutathione synthesis is catalysed by glutamate cysteine ligase (GCL), which is composed of catalytic and modifier subunits (GCLC and GCLM, respectively). The purpose of this study was to test the hypothesis that the -129C/T polymorphism in the promoter region of the glutamate-cysteine ligase catalytic subunit (GCLC) gene may be associated with the schizophrenia disease and if this polymorphism could affect plasma GSH concentrations. The GCLC -129C/T genotypes were determined in 138 schizophrenic patients and 123 healthy individuals using a PCR-based restriction fragment length polymorphism (RFLP) method. Glutathione levels: total glutathione (GSHt), reduced glutathione (GSHr) and oxidized glutathione (GSSG) were determined by spectrophotometry. The subjects with -129C/T and T/T genotypes are highly associated with schizophrenia. No association was found between glutathione levels and the -129C/C genotype, C/T and T/T genotypes in schizophrenic patients. The present finding indicated that the GCLC polymorphism seems to be associated with schizophrenia disease in at least a Tunisian population. |
|---|---|
| AbstractList | Glutathione (GSH) is a key regulator of oxidative balance in all mammals, especially in the central nervous system. The first step of glutathione synthesis is catalysed by glutamate cysteine ligase (GCL), which is composed of catalytic and modifier subunits (GCLC and GCLM, respectively). The purpose of this study was to test the hypothesis that the -129C/T polymorphism in the promoter region of the glutamate-cysteine ligase catalytic subunit (GCLC) gene may be associated with the schizophrenia disease and if this polymorphism could affect plasma GSH concentrations. The GCLC -129C/T genotypes were determined in 138 schizophrenic patients and 123 healthy individuals using a PCR-based restriction fragment length polymorphism (RFLP) method. Glutathione levels: total glutathione (GSHt), reduced glutathione (GSHr) and oxidized glutathione (GSSG) were determined by spectrophotometry. The subjects with -129C/T and T/T genotypes are highly associated with schizophrenia. No association was found between glutathione levels and the -129C/C genotype, C/T and T/T genotypes in schizophrenic patients. The present finding indicated that the GCLC polymorphism seems to be associated with schizophrenia disease in at least a Tunisian population. |
| Author | Raffa, Monia Kerkeni, Abdelhamid Mechri, Anwar Jrad, Besma Bel Hadj Khelil, Amel Haj |
| Author_xml | – sequence: 1 givenname: Monia surname: Raffa fullname: Raffa, Monia email: raffa_monia@yahoo.com organization: Research Laboratory of “Trace elements, free radicals and antioxidants”, Biophysical Department, Faculty of Medicine, University of Monastir, 5000 Monastir, Tunisia – sequence: 2 givenname: Besma Bel Hadj surname: Jrad fullname: Jrad, Besma Bel Hadj organization: Research Laboratory of “Genetic and Biodiversity” Superior Institute of Biotechnology, University of Monastir, 5000 Monastir, Tunisia – sequence: 3 givenname: Amel Haj surname: Khelil fullname: Khelil, Amel Haj organization: Biochemistry and Molecular Biology Laboratory, Faculty of Pharmacy, University of Monastir, 5000 Monastir, Tunisia – sequence: 4 givenname: Abdelhamid surname: Kerkeni fullname: Kerkeni, Abdelhamid organization: Research Laboratory of “Trace elements, free radicals and antioxidants”, Biophysical Department, Faculty of Medicine, University of Monastir, 5000 Monastir, Tunisia – sequence: 5 givenname: Anwar surname: Mechri fullname: Mechri, Anwar organization: Department of Psychiatry, Teaching Hospital of Monastir, 5000 Monastir, Tunisia |
| BookMark | eNqFkc2O1DAQhCO0SCzLvgEHH7kk2I6TbPaANFrxJ63EZe5Wx-nM9Mixg-2Awlvwxnh2OCAOcHJbrq9c6npZXDnvsCheC14JLtq3p-qALuBSyXyreFdx3j0rrqVqZMmFUld_zC-K2xhPnGdlJ_pOXRc_dzF6Q5DIO-Yntni7zT4sR4ozI8cOdk0wQ8LSbDEhOWSWDhCRGUhgt0SGxXVYHSWWcyD7TunIojnSD78cAzqCe7bL4pgdvEvBWxbTOm5nc2D7DEYCl_9dVvuU4lXxfAIb8fb3eVPsP7zfP3wqH798_PyweyxNXfepxEnyppOtGQSO7aSk4e00dROMPbR9U0-9aAwMQooGAMZWtO0w3EE39PmlVvVN8eZiuwT_dcWY9EzRoLXg0K9Ry7taSaFk02fp_UVqgo8x4KQNpaesKQBZLbg-N6FP-tKEPjeheadzExlWf8FLoBnC9j_s3QXDvIJvhEFHQ-gMjhTQJD16-rfBLySyq5g |
| CitedBy_id | crossref_primary_10_1016_j_biopha_2019_108642 crossref_primary_10_1186_s13071_020_04574_5 crossref_primary_10_1177_0269881119845820 |
| Cites_doi | 10.1089/ars.2010.3463 10.1016/j.freeradbiomed.2004.02.074 10.1111/j.1440-1746.2009.06001.x 10.1073/pnas.0706778104 10.1046/j.1460-9568.2000.00229.x 10.1016/j.freeradbiomed.2010.12.002 10.1164/rccm.200508-1281OC 10.1073/pnas.97.10.5101 10.1111/j.1440-1843.2006.00958.x 10.1016/j.neuroscience.2005.10.014 10.1086/507566 10.1016/j.ahj.2007.07.029 10.1515/BC.2003.059 10.1161/01.CIR.0000019739.66514.1E 10.1155/2006/248387 10.1055/s-2007-970574 10.1016/j.freeradbiomed.2013.05.001 10.1016/j.pnpbp.2009.06.018 10.1016/j.bbagen.2012.09.008 10.1093/ijnp/pyv110 10.1016/j.brainresbull.2008.10.015 10.1016/S0735-1097(02)02866-8 10.1016/j.freeradbiomed.2004.06.040 10.1016/S0006-2952(02)01174-7 10.1093/nar/16.3.1215 |
| ContentType | Journal Article |
| Copyright | 2016 Elsevier Inc. |
| Copyright_xml | – notice: 2016 Elsevier Inc. |
| DBID | AAYXX CITATION 7S9 L.6 |
| DOI | 10.1016/j.genrep.2016.07.007 |
| DatabaseName | CrossRef AGRICOLA AGRICOLA - Academic |
| DatabaseTitle | CrossRef AGRICOLA AGRICOLA - Academic |
| DatabaseTitleList | AGRICOLA |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 2452-0144 |
| EndPage | 252 |
| ExternalDocumentID | 10_1016_j_genrep_2016_07_007 S2452014416300450 |
| GroupedDBID | --M 0R~ 457 4G. 7-5 AACTN AAEDT AAEDW AAIAV AAKOC AALRI AAOAW AAXUO ABMAC ABUDA ABYKQ ACDAQ ACGFS ACRLP ADBBV ADEZE AEBSH AEHWI AFKWA AFTJW AFXIZ AGHFR AGUBO AIEXJ AIKHN AITUG AJBFU AJOXV ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ AXJTR BKOJK BLXMC EBS EFJIC EFLBG EJD FDB FIRID FYGXN KOM O9- OAUVE ROL SPCBC SSU SSZ T5K ~G- AAQFI AATTM AAXKI AAYWO AAYXX ABJNI ACVFH ADCNI AEIPS AEUPX AFJKZ AFPUW AGCQF AGRNS AIGII AIIUN AKBMS AKYEP ANKPU APXCP BNPGV CITATION SSH 7S9 EFKBS L.6 |
| ID | FETCH-LOGICAL-c339t-ef205726cb1ed6f42c06ff7fad9a6953f915cab1215aaad6166bb8a7b9f91343 |
| IEDL.DBID | AIKHN |
| ISSN | 2452-0144 |
| IngestDate | Fri Sep 05 05:35:45 EDT 2025 Tue Jul 01 02:47:30 EDT 2025 Thu Apr 24 23:13:11 EDT 2025 Fri Feb 23 02:49:30 EST 2024 |
| IsPeerReviewed | false |
| IsScholarly | true |
| Keywords | Oxidative stress MgCl2 OR NS CI dNTP Schizophrenia DSM-IV-TR EDTA GCL SD GCLC DNA GSHr GSHt TNR GSSG oxidized GCLM GSH PCR RFLP ml Glutathione |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c339t-ef205726cb1ed6f42c06ff7fad9a6953f915cab1215aaad6166bb8a7b9f91343 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| PQID | 2834214259 |
| PQPubID | 24069 |
| PageCount | 4 |
| ParticipantIDs | proquest_miscellaneous_2834214259 crossref_citationtrail_10_1016_j_genrep_2016_07_007 crossref_primary_10_1016_j_genrep_2016_07_007 elsevier_sciencedirect_doi_10_1016_j_genrep_2016_07_007 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2016-09-01 |
| PublicationDateYYYYMMDD | 2016-09-01 |
| PublicationDate_xml | – month: 09 year: 2016 text: 2016-09-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationTitle | Gene reports |
| PublicationYear | 2016 |
| Publisher | Elsevier Inc |
| Publisher_xml | – name: Elsevier Inc |
| References | Butticaz, Gysin, Cuénod, Do (bb0025) 2011; 50 Zuo, Xu, Luo, Zhu, Zhu (bb0145) 2007; 35 Do (bb0045) 2000; 12 Lu (bb0085) 2013; 1830 Shi, Osei-Frimpong, Kala, Kala, Barrios, Habib (bb0120) 2000; 97 Liu, Li, Zhou, Zhong, Ran (bb0080) 2007; 12 Tosic (bb0135) 2006; 79 Dalton, Chen, Schneider, Nebert, Shertzer (bb0040) 2004; 37 Gysin (bb0055) 2007; 104 Jaiswal (bb0070) 2004; 36 Gysin (bb0065) 2011; 15 Miller, Dykes, Polesky (bb0095) 1988; 16 Akerboom, Sies (bb0005) 1981 Ristoff, Augustson, Geissler (bb0115) 2000; 95 Steullet, Neijt, Cuénod, Do (bb0130) 2006; 137 Oliveira, Stefano, Cavaleiro, Zanella Fortes, Vieira (bb0105) 2010; 25 Bharath, Hsu, Kaur, Rajagopalan, Andersen (bb0020) 2002; 64 Dringen, Hirrlinger (bb0050) 2003; 384 Koide (bb0075) 2003; 41 Smeyne, Smeyne (bb0125) 2014; 62 Gysin, Riederer, Cuénod, Do, Riederer (bb0060) 2009; 79 Nakamura (bb0100) 2002; 105 Corcoba (bb0035) 2015; 19 Yao, Leonard, Reddy (bb0140) 2006; 22 Raffa, Mechri, Othman, Fendri, Gaha, Kerkeni (bb0110) 2009; 33 Bekris (bb0015) 2007; 115 McKone (bb0090) 2006; 174 Campolo, Penco, Bianchi, Colombo, Parolini, Caruso (bb0030) 2007; 154 American Psychiatric Association (bb0010) 2000 Butticaz (10.1016/j.genrep.2016.07.007_bb0025) 2011; 50 Tosic (10.1016/j.genrep.2016.07.007_bb0135) 2006; 79 Do (10.1016/j.genrep.2016.07.007_bb0045) 2000; 12 Dringen (10.1016/j.genrep.2016.07.007_bb0050) 2003; 384 Smeyne (10.1016/j.genrep.2016.07.007_bb0125) 2014; 62 Zuo (10.1016/j.genrep.2016.07.007_bb0145) 2007; 35 Bekris (10.1016/j.genrep.2016.07.007_bb0015) 2007; 115 Akerboom (10.1016/j.genrep.2016.07.007_bb0005) 1981 Ristoff (10.1016/j.genrep.2016.07.007_bb0115) 2000; 95 Dalton (10.1016/j.genrep.2016.07.007_bb0040) 2004; 37 Gysin (10.1016/j.genrep.2016.07.007_bb0060) 2009; 79 Shi (10.1016/j.genrep.2016.07.007_bb0120) 2000; 97 American Psychiatric Association (10.1016/j.genrep.2016.07.007_bb0010) 2000 Bharath (10.1016/j.genrep.2016.07.007_bb0020) 2002; 64 Campolo (10.1016/j.genrep.2016.07.007_bb0030) 2007; 154 Koide (10.1016/j.genrep.2016.07.007_bb0075) 2003; 41 Liu (10.1016/j.genrep.2016.07.007_bb0080) 2007; 12 Gysin (10.1016/j.genrep.2016.07.007_bb0065) 2011; 15 Corcoba (10.1016/j.genrep.2016.07.007_bb0035) 2015; 19 Oliveira (10.1016/j.genrep.2016.07.007_bb0105) 2010; 25 Miller (10.1016/j.genrep.2016.07.007_bb0095) 1988; 16 Steullet (10.1016/j.genrep.2016.07.007_bb0130) 2006; 137 Lu (10.1016/j.genrep.2016.07.007_bb0085) 2013; 1830 Nakamura (10.1016/j.genrep.2016.07.007_bb0100) 2002; 105 Jaiswal (10.1016/j.genrep.2016.07.007_bb0070) 2004; 36 Raffa (10.1016/j.genrep.2016.07.007_bb0110) 2009; 33 Yao (10.1016/j.genrep.2016.07.007_bb0140) 2006; 22 McKone (10.1016/j.genrep.2016.07.007_bb0090) 2006; 174 Gysin (10.1016/j.genrep.2016.07.007_bb0055) 2007; 104 |
| References_xml | – volume: 1830 start-page: 3143 year: 2013 end-page: 3153 ident: bb0085 article-title: Glutathionesynthesis publication-title: Biochim. Biophys. Acta – volume: 137 start-page: 807 year: 2006 end-page: 819 ident: bb0130 article-title: Synaptic plasticity impairment and hypofunction of NMDA receptors induced by glutathione deficit: relevance to schizophrenia publication-title: Neuroscience – volume: 64 start-page: 1037 year: 2002 end-page: 1048 ident: bb0020 article-title: Glutathione, iron and Parkinson's disease publication-title: Biochem. Pharmacol. – volume: 97 start-page: 5101 year: 2000 end-page: 5106 ident: bb0120 article-title: Glutathione synthesis is essential for mouse development but not for cell growth in culture publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 19 year: 2015 ident: bb0035 article-title: Glutathione deficit affects the integrity and function of the fimbria/fornix and anterior commissure in mice: relevance for schizophrenia publication-title: Int. J. Neuropsychopharmacol. – volume: 79 start-page: 46 year: 2009 end-page: 52 ident: bb0060 article-title: Skin fibroblast model to study an impaired glutathione synthesis: consequences of a genetic polymorphism on the proteome publication-title: Brain Res. Bull. – volume: 25 start-page: 357 year: 2010 end-page: 361 ident: bb0105 article-title: Association of polymorphisms of glutamate-cystein ligase and microsomal triglyceride transfer protein genes in non-alcoholic fatty liver disease publication-title: J. Gastroenterol. Hepatol. – volume: 174 start-page: 415 year: 2006 end-page: 419 ident: bb0090 article-title: Variants in the glutamate-cysteine-ligase gene are associated with cystic fibrosis lung disease publication-title: Am. J. Respir. Crit. Care Med. – volume: 50 start-page: 617 year: 2011 end-page: 623 ident: bb0025 article-title: Interaction of GAG trinucleotide repeat and C-129T polymorphisms impairs expression of the glutamate-cysteine ligase catalytic subunit gene publication-title: Free Radic. Biol. Med. – volume: 12 start-page: 3721 year: 2000 end-page: 3728 ident: bb0045 article-title: Schizophrenia: glutathione deficit in cerebrospinal fluid and prefrontal cortex in vivo publication-title: Eur. J. Neurosci. – volume: 105 start-page: 2968 year: 2002 end-page: 2973 ident: bb0100 article-title: Polymorphism in the 5′-flanking region of human glutamate-cysteine ligase modifier subunit gene is associated with myocardial infarction publication-title: Circulation – year: 2000 ident: bb0010 article-title: Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision: DSM-IV-TR – volume: 37 start-page: 1511 year: 2004 end-page: 1526 ident: bb0040 article-title: Genetically altered mice to evaluate glutathione homeostasis in health and disease publication-title: Free Radic. Biol. Med. – volume: 384 start-page: 505 year: 2003 end-page: 516 ident: bb0050 article-title: Glutathione path ways in the brain publication-title: Biol. Chem. – volume: 62 start-page: 13 year: 2014 end-page: 25 ident: bb0125 article-title: Glutathione metabolism and Parkinson'sdisease publication-title: Free Radic. Biol. Med. – volume: 104 start-page: 16621 year: 2007 end-page: 16626 ident: bb0055 article-title: Impaired glutathione synthesis in schizophrenia: convergent genetic and functional evidence publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 95 start-page: 2193 year: 2000 end-page: 2219 ident: bb0115 article-title: A missense mutation in the heavy subunit of gamma-glutamylcysteine synthetase gene causes hemolytic anemia publication-title: Blood – volume: 16 start-page: 1215 year: 1988 ident: bb0095 article-title: A simple salting out procedure for extracting DNA from human nucleated cells publication-title: Nucleic Acids Res. – volume: 33 start-page: 1178 year: 2009 end-page: 1183 ident: bb0110 article-title: Decreased glutathione levels and antioxidant enzyme activities in untreated and treatedschizophrenic patients publication-title: Prog. Neuro-Psychopharmacol. Biol. Psychiatry – volume: 35 start-page: 637 year: 2007 end-page: 640 ident: bb0145 article-title: The glutamate–cysteine ligase catalytic subunit gene C-129 T and modifier subunit gene G-23 T polymorphisms and risk for coronary diseases publication-title: Zhonghua Xin Xue Guan Bing Za Zhi – volume: 22 start-page: 83 year: 2006 end-page: 93 ident: bb0140 article-title: Altered glutathione redox state in schizophrenia publication-title: Dis. Markers – volume: 12 start-page: 29 year: 2007 end-page: 33 ident: bb0080 article-title: Genetic analysis of CC16, OGG1 and GCLC polymorphisms and susceptibility to COPD publication-title: Respirology – volume: 115 start-page: 221 year: 2007 end-page: 228 ident: bb0015 article-title: Glutamate cysteine ligase catalytic subunit promoter polymorphisms and associations with type 1 diabetes age-at-onset and GAD65 autoantibody levels publication-title: Exp. Clin. Endocrinol. Diabetes – volume: 15 start-page: 2003 year: 2011 end-page: 2010 ident: bb0065 article-title: Genetic dysregulation of glutathione synthesis predicts alteration of plasma thiol redox status in schizophrenia publication-title: Antioxid. Redox Signal. – volume: 36 start-page: 1199 year: 2004 end-page: 1207 ident: bb0070 article-title: Nrf2 signaling in coordinated activation of antioxidant gene expression publication-title: Free Radic. Biol. Med. – volume: 41 start-page: 539 year: 2003 end-page: 545 ident: bb0075 article-title: Association of polymorphism in glutamate-cysteine ligase catalytic subunit gene with coronary vasomotor dysfunction and myocardial infarction publication-title: J. Am. Coll. Cardiol. – start-page: 373 year: 1981 end-page: 382 ident: bb0005 article-title: Assay of glutathione, glutathione disulfide and glutathione mixed disulfides in biological samples publication-title: Methods Enzymol Detoxification and Drug Metabolism: Conjugation and Related Systems – volume: 79 start-page: 586 year: 2006 end-page: 592 ident: bb0135 article-title: Schizophrenia and oxidative stress: glutamate cysteine ligase modifier as a susceptibility gene publication-title: Am. J. Hum. Genet. – volume: 154 start-page: 1123 year: 2007 end-page: 1129 ident: bb0030 article-title: Glutamate-cysteine ligase polymorphism, hypertension, and male sex are associated with cardiovascular events. Biochemical and genetic characterization of Italian subpopulation publication-title: Am. Heart J. – volume: 35 start-page: 637 year: 2007 ident: 10.1016/j.genrep.2016.07.007_bb0145 article-title: The glutamate–cysteine ligase catalytic subunit gene C-129 T and modifier subunit gene G-23 T polymorphisms and risk for coronary diseases publication-title: Zhonghua Xin Xue Guan Bing Za Zhi – volume: 15 start-page: 2003 issue: 7 year: 2011 ident: 10.1016/j.genrep.2016.07.007_bb0065 article-title: Genetic dysregulation of glutathione synthesis predicts alteration of plasma thiol redox status in schizophrenia publication-title: Antioxid. Redox Signal. doi: 10.1089/ars.2010.3463 – volume: 36 start-page: 1199 year: 2004 ident: 10.1016/j.genrep.2016.07.007_bb0070 article-title: Nrf2 signaling in coordinated activation of antioxidant gene expression publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2004.02.074 – volume: 25 start-page: 357 year: 2010 ident: 10.1016/j.genrep.2016.07.007_bb0105 article-title: Association of polymorphisms of glutamate-cystein ligase and microsomal triglyceride transfer protein genes in non-alcoholic fatty liver disease publication-title: J. Gastroenterol. Hepatol. doi: 10.1111/j.1440-1746.2009.06001.x – volume: 104 start-page: 16621 issue: 42 year: 2007 ident: 10.1016/j.genrep.2016.07.007_bb0055 article-title: Impaired glutathione synthesis in schizophrenia: convergent genetic and functional evidence publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.0706778104 – start-page: 373 year: 1981 ident: 10.1016/j.genrep.2016.07.007_bb0005 article-title: Assay of glutathione, glutathione disulfide and glutathione mixed disulfides in biological samples – volume: 12 start-page: 3721 year: 2000 ident: 10.1016/j.genrep.2016.07.007_bb0045 article-title: Schizophrenia: glutathione deficit in cerebrospinal fluid and prefrontal cortex in vivo publication-title: Eur. J. Neurosci. doi: 10.1046/j.1460-9568.2000.00229.x – volume: 50 start-page: 617 issue: 5 year: 2011 ident: 10.1016/j.genrep.2016.07.007_bb0025 article-title: Interaction of GAG trinucleotide repeat and C-129T polymorphisms impairs expression of the glutamate-cysteine ligase catalytic subunit gene publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2010.12.002 – volume: 174 start-page: 415 issue: 4 year: 2006 ident: 10.1016/j.genrep.2016.07.007_bb0090 article-title: Variants in the glutamate-cysteine-ligase gene are associated with cystic fibrosis lung disease publication-title: Am. J. Respir. Crit. Care Med. doi: 10.1164/rccm.200508-1281OC – volume: 97 start-page: 5101 issue: 10 year: 2000 ident: 10.1016/j.genrep.2016.07.007_bb0120 article-title: Glutathione synthesis is essential for mouse development but not for cell growth in culture publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.97.10.5101 – volume: 12 start-page: 29 issue: 1 year: 2007 ident: 10.1016/j.genrep.2016.07.007_bb0080 article-title: Genetic analysis of CC16, OGG1 and GCLC polymorphisms and susceptibility to COPD publication-title: Respirology doi: 10.1111/j.1440-1843.2006.00958.x – volume: 137 start-page: 807 issue: 3 year: 2006 ident: 10.1016/j.genrep.2016.07.007_bb0130 article-title: Synaptic plasticity impairment and hypofunction of NMDA receptors induced by glutathione deficit: relevance to schizophrenia publication-title: Neuroscience doi: 10.1016/j.neuroscience.2005.10.014 – volume: 79 start-page: 586 issue: 3 year: 2006 ident: 10.1016/j.genrep.2016.07.007_bb0135 article-title: Schizophrenia and oxidative stress: glutamate cysteine ligase modifier as a susceptibility gene publication-title: Am. J. Hum. Genet. doi: 10.1086/507566 – volume: 154 start-page: 1123 issue: 6 year: 2007 ident: 10.1016/j.genrep.2016.07.007_bb0030 article-title: Glutamate-cysteine ligase polymorphism, hypertension, and male sex are associated with cardiovascular events. Biochemical and genetic characterization of Italian subpopulation publication-title: Am. Heart J. doi: 10.1016/j.ahj.2007.07.029 – volume: 384 start-page: 505 year: 2003 ident: 10.1016/j.genrep.2016.07.007_bb0050 article-title: Glutathione path ways in the brain publication-title: Biol. Chem. doi: 10.1515/BC.2003.059 – volume: 105 start-page: 2968 year: 2002 ident: 10.1016/j.genrep.2016.07.007_bb0100 article-title: Polymorphism in the 5′-flanking region of human glutamate-cysteine ligase modifier subunit gene is associated with myocardial infarction publication-title: Circulation doi: 10.1161/01.CIR.0000019739.66514.1E – volume: 22 start-page: 83 year: 2006 ident: 10.1016/j.genrep.2016.07.007_bb0140 article-title: Altered glutathione redox state in schizophrenia publication-title: Dis. Markers doi: 10.1155/2006/248387 – volume: 115 start-page: 221 issue: 4 year: 2007 ident: 10.1016/j.genrep.2016.07.007_bb0015 article-title: Glutamate cysteine ligase catalytic subunit promoter polymorphisms and associations with type 1 diabetes age-at-onset and GAD65 autoantibody levels publication-title: Exp. Clin. Endocrinol. Diabetes doi: 10.1055/s-2007-970574 – volume: 62 start-page: 13 year: 2014 ident: 10.1016/j.genrep.2016.07.007_bb0125 article-title: Glutathione metabolism and Parkinson'sdisease publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2013.05.001 – volume: 33 start-page: 1178 issue: 7 year: 2009 ident: 10.1016/j.genrep.2016.07.007_bb0110 article-title: Decreased glutathione levels and antioxidant enzyme activities in untreated and treatedschizophrenic patients publication-title: Prog. Neuro-Psychopharmacol. Biol. Psychiatry doi: 10.1016/j.pnpbp.2009.06.018 – year: 2000 ident: 10.1016/j.genrep.2016.07.007_bb0010 – volume: 1830 start-page: 3143 year: 2013 ident: 10.1016/j.genrep.2016.07.007_bb0085 article-title: Glutathionesynthesis publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbagen.2012.09.008 – volume: 19 issue: 3 year: 2015 ident: 10.1016/j.genrep.2016.07.007_bb0035 article-title: Glutathione deficit affects the integrity and function of the fimbria/fornix and anterior commissure in mice: relevance for schizophrenia publication-title: Int. J. Neuropsychopharmacol. doi: 10.1093/ijnp/pyv110 – volume: 79 start-page: 46 issue: 1 year: 2009 ident: 10.1016/j.genrep.2016.07.007_bb0060 article-title: Skin fibroblast model to study an impaired glutathione synthesis: consequences of a genetic polymorphism on the proteome publication-title: Brain Res. Bull. doi: 10.1016/j.brainresbull.2008.10.015 – volume: 41 start-page: 539 issue: 4 year: 2003 ident: 10.1016/j.genrep.2016.07.007_bb0075 article-title: Association of polymorphism in glutamate-cysteine ligase catalytic subunit gene with coronary vasomotor dysfunction and myocardial infarction publication-title: J. Am. Coll. Cardiol. doi: 10.1016/S0735-1097(02)02866-8 – volume: 37 start-page: 1511 year: 2004 ident: 10.1016/j.genrep.2016.07.007_bb0040 article-title: Genetically altered mice to evaluate glutathione homeostasis in health and disease publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2004.06.040 – volume: 64 start-page: 1037 issue: 5–6 year: 2002 ident: 10.1016/j.genrep.2016.07.007_bb0020 article-title: Glutathione, iron and Parkinson's disease publication-title: Biochem. Pharmacol. doi: 10.1016/S0006-2952(02)01174-7 – volume: 95 start-page: 2193 year: 2000 ident: 10.1016/j.genrep.2016.07.007_bb0115 article-title: A missense mutation in the heavy subunit of gamma-glutamylcysteine synthetase gene causes hemolytic anemia publication-title: Blood – volume: 16 start-page: 1215 year: 1988 ident: 10.1016/j.genrep.2016.07.007_bb0095 article-title: A simple salting out procedure for extracting DNA from human nucleated cells publication-title: Nucleic Acids Res. doi: 10.1093/nar/16.3.1215 |
| SSID | ssj0001671974 |
| Score | 1.9953096 |
| Snippet | Glutathione (GSH) is a key regulator of oxidative balance in all mammals, especially in the central nervous system. The first step of glutathione synthesis is... |
| SourceID | proquest crossref elsevier |
| SourceType | Aggregation Database Enrichment Source Index Database Publisher |
| StartPage | 249 |
| SubjectTerms | GCLC Glutathione Oxidative stress Schizophrenia |
| Title | Association of polymorphism in glutamate-cysteine ligase catalytic subunit gene with schizophrenia: A case-control study in a Tunisian population |
| URI | https://dx.doi.org/10.1016/j.genrep.2016.07.007 https://www.proquest.com/docview/2834214259 |
| Volume | 4 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1JSywxEA6iCO8ibg93IngNM70lE2-DKKOiF0fwFrJKP-b1DPbMwZ_hP7Yq3e2GIHjsJlXdpJKqSlXlK0JONJe-n-qM-b5xGK1yTCd5YFnQhjvBhRF4Ufjmlo_u86uH4mGJnHV3YbCsstX9jU6P2rp902tnszcry94d5gzjeSCiRuG5fSXNJIcT2Mrw8np0-x5q4SKREY8ZSRjSdJfoYqVXlBRiVyYNkCe2lv3eSH1R19EGXayTtdZ5pMPm_zbIkq82yWrTTvJ5i7x8mGs6DXQ2ncDJHiayrP_TsqKPsMo0eKieWcRvBv-STspHMGM0BnGegSutF2YBu5zC33qKQVpafyzLO6VDGFwDh6bEnUZ4WmSu6Rgz47Da4LtdU7BtMr44H5-NWNtygdksk3PmQwoOXMqtSbzjIU9tn4cggnYSpFpkQSaF1QYhKbTWjiecGzPQwsiAKfzsL1muppXfIZSL1NkwsM54k6cG9LsdFGEgdSFT7bzYJVk3xcq2cOTYFWOiurqzf6oRjELBqD7myYGKvVHNGjiOH8aLTnrq07JSYDF-oDzuhK1gx2EaRVd-uqgVOGQ5AtUVcu_X3PfJH3xqitUOyPL8aeEPwbuZm6N29b4CUcn-YA |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LTxsxELYiUFUuqJQiKI-6Elcr2Zcdc4uiolAgl6YSN8tPtChsom5y4Gfwj5nx7rZQISFx3fXMrjzjmbFn_A0hp5pLP0h1xvzAODytckwneWBZ0IY7wYUReFH4esonv_OfN8VNj4y7uzBYVtna_samR2vdPum3s9lflmX_F-YM434gokbhvn0T0alA2TdHF5eT6b-jFi4SGfGYkYQhTXeJLlZ6RUkhdmXSAHlia9nXndR_5jr6oPNPZLsNHumo-b8d0vPVZ_KhaSf5sEsen801XQS6XMxhZw8TWdb3tKzoLWiZhgjVM4v4zRBf0nl5C26MxkOcB-BK67VZwyqn8Lee4iEtrZ-X5Z3REQyugUNT4k4jPC0y13SGmXHQNvhu1xTsC5md_5iNJ6xtucBslskV8yGFAC7l1iTe8ZCndsBDEEE7CVItsiCTwmqDkBRaa8cTzo0ZamFkwBR-tkc2qkXl9wnlInU2DK0z3uSpAftuh0UYSl3IVDsvDkjWTbGyLRw5dsWYq67u7E41glEoGDXAPDlQsb9UywaO443xopOeeqFWCjzGG5TfO2ErWHGYRtGVX6xrBQFZjkB1hfz6bu7fyMfJ7PpKXV1MLw_JFr5pCteOyMbqz9ofQ6SzMietJj8BU2wBVQ |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Association+of+polymorphism+in+glutamate-cysteine+ligase+catalytic+subunit+gene+with+schizophrenia%3A+A+case-control+study+in+a+Tunisian+population&rft.jtitle=Gene+reports&rft.au=Raffa%2C+Monia&rft.au=Jrad%2C+Besma+Bel+Hadj&rft.au=Khelil%2C+Amel+Haj&rft.au=Kerkeni%2C+Abdelhamid&rft.date=2016-09-01&rft.pub=Elsevier+Inc&rft.issn=2452-0144&rft.eissn=2452-0144&rft.volume=4&rft.spage=249&rft.epage=252&rft_id=info:doi/10.1016%2Fj.genrep.2016.07.007&rft.externalDocID=S2452014416300450 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2452-0144&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2452-0144&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2452-0144&client=summon |