Dysregulation of the Hypothalamic-Pituitary-Adrenal Axis in Short Children With and Without Growth Hormone Deficiency

The effects of L-dopamine (LD) administration and insulin-induced hypoglycemia in adrenocorticotropin (ACTH) and cortisol secretion were studied in 14 short boys. LD caused moderate changes in both hormones. The four boys with isolated, idiopathic growth hormone (GH) deficiency (IGD) demonstrated a...

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Published inJournal of Pediatric Endocrinology and Metabolism Vol. 13; no. 8; pp. 1095 - 1100
Main Authors Stratakis, C.A., Rusovici, D.E., Kulin, H.E., Finkelstein, J.W.
Format Journal Article
LanguageEnglish
Published Germany De Gruyter 01.09.2000
Subjects
Adolescent
Adrenocorticotropic Hormone - blood
Body Height
Child
Dopamine - pharmacology
Human Growth Hormone - deficiency
Humans
Hydrocortisone - blood
Hypoglycemia - blood
Hypoglycemia - chemically induced
Hypoglycemic Agents
Hypothalamo-Hypophyseal System - physiopathology
Insulin
Male
Pituitary-Adrenal System - physiopathology
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Abstract The effects of L-dopamine (LD) administration and insulin-induced hypoglycemia in adrenocorticotropin (ACTH) and cortisol secretion were studied in 14 short boys. LD caused moderate changes in both hormones. The four boys with isolated, idiopathic growth hormone (GH) deficiency (IGD) demonstrated a greater cortisol increase in response to hypoglycemia than the 10 boys with normal GH secretion. In at least some short children with IGD, abnormal regulation of the hypothalamic-pituitary-adrenal axis may be present.
AbstractList The effects of L-dopamine (LD) administration and insulin-induced hypoglycemia in adrenocorticotropin (ACTH) and cortisol secretion were studied in 14 short boys. LD caused moderate changes in both hormones. The four boys with isolated, idiopathic growth hormone (GH) deficiency (IGD) demonstrated a greater cortisol increase in response to hypoglycemia than the 10 boys with normal GH secretion. In at least some short children with IGD, abnormal regulation of the hypothalamic-pituitary-adrenal axis may be present.
Author Kulin, H.E.
Finkelstein, J.W.
Stratakis, C.A.
Rusovici, D.E.
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SubjectTerms Adolescent
Adrenocorticotropic Hormone - blood
Body Height
Child
Dopamine - pharmacology
Human Growth Hormone - deficiency
Humans
Hydrocortisone - blood
Hypoglycemia - blood
Hypoglycemia - chemically induced
Hypoglycemic Agents
Hypothalamo-Hypophyseal System - physiopathology
Insulin
Male
Pituitary-Adrenal System - physiopathology
Title Dysregulation of the Hypothalamic-Pituitary-Adrenal Axis in Short Children With and Without Growth Hormone Deficiency
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