Low-activity haplotype of the microsomal epoxide hydrolase gene is protective against placental abruption

• Published in: Journal of the Society for Gynecologic Investigation Vol. 11; no. 8; p. 540
• Main Authors: Toivonen, Sari, Romppanen, Eeva-Liisa, Hiltunen, Mikko, Helisalmi, Seppo, Keski-Nisula, Leea, Punnonen, Kari, Heinonen, Seppo
• Format: Journal Article
• Language: English
• Published: United States 01.12.2004
• Subjects: Abruptio Placentae - enzymology; Abruptio Placentae - genetics; Adult; Alleles; Epoxide Hydrolases - genetics; Exons; Female; Gene Frequency; Genotype; Haplotypes; Humans; Polymorphism, Single Nucleotide; Pregnancy

We wanted to determine whether genetic variability in the gene encoding microsomal epoxide hydrolase (EPHX) contributes to individual differences in susceptibility to the occurrence of placental abruption. The study involved 117 women with placental abruption and 115 healthy control pregnant women w...