Imaging the serotonin transporter using 123I-ADAM in the human brain
The aim of this study was to examine the feasibility of 123I-ADAM to image the serotonin transporter (SERT) in Asian (Taiwanese) subjects. Single photon emission computed tomography (SPECT) scans were performed on nine healthy volunteers who were s-allele carriers at the polymorphism within the sero...
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| Published in | Psychiatry research. Neuroimaging Vol. 172; no. 1; pp. 38 - 43 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Shannon
Elsevier Ireland Ltd
2009
Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0925-4927 1872-7506 |
| DOI | 10.1016/j.pscychresns.2008.12.006 |
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| Abstract | The aim of this study was to examine the feasibility of
123I-ADAM to image the serotonin transporter (SERT) in Asian (Taiwanese) subjects. Single photon emission computed tomography (SPECT) scans were performed on nine healthy volunteers who were s-allele carriers at the polymorphism within the serotonin transporter promoter region (SERTPR) after intravenous bolus injection of
123I-ADAM. Quantification of
123I-ADAM binding was performed using the ratio equilibrium method (REM) with specific uptake ratio (SUR) and a simplified reference tissue model (SRTM). Curve-fitting techniques were used to obtain the peak equilibrium point from 241 to 301 min (average 264
±
20 min) after injection of
123I-ADAM for the midbrain and from 215 to 270 min (average 235
±
18 min) after injection of
123I-ADAM for the striatum. Two sets of SUR were obtained by either curve fitting (estimated values) or integrated period from 240 to 270 min (observed values). The estimated values of SUR were 2.11
±
0.51 for the midbrain and 1.50
±
0.44 for the striatum, whereas the observed values were 2.11
±
0.83 for the midbrain and 1.24
±
0.31 for the striatum. The SRTM showed that the binding potential (BP) was 2.10
±
0.66 for the midbrain and 1.35
±
0.25 for the striatum. There was a good correlation between estimated SUR, observed SUR and SRTM in the midbrain but not in the striatum. The optimal scanning duration for both the midbrain and the striatum should be 220 to 280 min similar to that suggested by previous studies in Caucasians. However, due to the low signal-to-noise ratio in the striatum,
123I-ADAM could be an ideal tracer for imaging SERT in the midbrain but not in the striatum. |
|---|---|
| AbstractList | The aim of this study was to examine the feasibility of
123I-ADAM to image the serotonin transporter (SERT) in Asian (Taiwanese) subjects. Single photon emission computed tomography (SPECT) scans were performed on nine healthy volunteers who were s-allele carriers at the polymorphism within the serotonin transporter promoter region (SERTPR) after intravenous bolus injection of
123I-ADAM. Quantification of
123I-ADAM binding was performed using the ratio equilibrium method (REM) with specific uptake ratio (SUR) and a simplified reference tissue model (SRTM). Curve-fitting techniques were used to obtain the peak equilibrium point from 241 to 301 min (average 264
±
20 min) after injection of
123I-ADAM for the midbrain and from 215 to 270 min (average 235
±
18 min) after injection of
123I-ADAM for the striatum. Two sets of SUR were obtained by either curve fitting (estimated values) or integrated period from 240 to 270 min (observed values). The estimated values of SUR were 2.11
±
0.51 for the midbrain and 1.50
±
0.44 for the striatum, whereas the observed values were 2.11
±
0.83 for the midbrain and 1.24
±
0.31 for the striatum. The SRTM showed that the binding potential (BP) was 2.10
±
0.66 for the midbrain and 1.35
±
0.25 for the striatum. There was a good correlation between estimated SUR, observed SUR and SRTM in the midbrain but not in the striatum. The optimal scanning duration for both the midbrain and the striatum should be 220 to 280 min similar to that suggested by previous studies in Caucasians. However, due to the low signal-to-noise ratio in the striatum,
123I-ADAM could be an ideal tracer for imaging SERT in the midbrain but not in the striatum. |
| Author | Chung, Ming-Yi Chou, Yuan-Hwa Su, Tung-Ping Chen, Shih-Pei Chen, Chia-Chieh Yang, Bang-Hung Wang, Shyh-Jen |
| Author_xml | – sequence: 1 givenname: Yuan-Hwa surname: Chou fullname: Chou, Yuan-Hwa organization: Department of Psychiatry, Taipei Veterans General Hospital & National Yang Ming University, Taipei, Taiwan – sequence: 2 givenname: Bang-Hung surname: Yang fullname: Yang, Bang-Hung organization: Department of Nuclear Medicine, Taipei Veterans General Hospital & National Yang Ming University, Taipei, Taiwan – sequence: 3 givenname: Ming-Yi surname: Chung fullname: Chung, Ming-Yi organization: Faculty of Life Sciences & Institute of Genome Sciences, National Yang Ming University, Taipei, Taiwan – sequence: 4 givenname: Shih-Pei surname: Chen fullname: Chen, Shih-Pei organization: Department of Nuclear Medicine, Taipei Veterans General Hospital & National Yang Ming University, Taipei, Taiwan – sequence: 5 givenname: Tung-Ping surname: Su fullname: Su, Tung-Ping organization: Department of Psychiatry, Taipei Veterans General Hospital & National Yang Ming University, Taipei, Taiwan – sequence: 6 givenname: Chia-Chieh surname: Chen fullname: Chen, Chia-Chieh organization: eInstitute of Nuclear Energy Research, Lung-Tan, Taoyuan, Taiwan – sequence: 7 givenname: Shyh-Jen surname: Wang fullname: Wang, Shyh-Jen email: jwshyh@vghtpe.gov.tw organization: Department of Nuclear Medicine, Taipei Veterans General Hospital & National Yang Ming University, Taipei, Taiwan |
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| Keywords | Striatum 123I-ADAM Midbrain Serotonin transporter SPECT Radionuclide study Human Central nervous system Basal ganglion Corpus striatum Single photon emission tomography Photon Encephalon Imaging I-ADAM |
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123I-ADAM to image the serotonin transporter (SERT) in Asian (Taiwanese) subjects. Single photon... |
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| SubjectTerms | 123I-ADAM Biological and medical sciences Medical sciences Midbrain Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Serotonin transporter SPECT Striatum |
| Title | Imaging the serotonin transporter using 123I-ADAM in the human brain |
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