Streptogramins and their Potential Role in Geriatric Medicine

• Published in: Drugs & aging Vol. 13; no. 6; pp. 443 - 465
• Main Authors: Lomaestro, Ben M., Briceland, Laurie L.
• Format: Journal Article
• Language: English
• Published: Auckland Adis International 01.12.1998
• Subjects: Aged; Aging - metabolism; Anti-Bacterial Agents - pharmacokinetics; Anti-Bacterial Agents - therapeutic use; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Area Under Curve; Bacterial Infections - drug therapy; Biological and medical sciences; Drug Combinations; Drug Resistance, Microbial; Female; Geriatrics; Humans; Male; Medical sciences; Microbial Sensitivity Tests; Pharmacology. Drug treatments; Virginiamycin - analogs & derivatives; Virginiamycin - pharmacokinetics; Virginiamycin - therapeutic use; Human; Drug combination; Senescence; Toxicity; Use; Quinupristin; Review; Biological activity; Dalfopristin; Resistance; Antibiotic; Secondary effect; Streptogramins; Drug interaction; Activity spectrum; Antibacterial agent; Mechanism of action; Pharmacokinetics; Elderly; Geriatrics

Despite advances in antimicrobial chemotherapy over recent decades, morbidity and mortality secondary to infection continues to rise. In addition, the incidence of infection caused by resistant organisms has also increased. Concurrently, the elderly are living longer than prior generations, often wi...