Inhibition of glutaminolysis ameliorates lupus by regulating T and B cell subsets and downregulating the mTOR/P70S6K/4EBP1 and NLRP3/caspase-1/IL-1β pathways in MRL/lpr mice

• Published in: International immunopharmacology Vol. 112; p. 109133
• Main Authors: Zhang, Xiaomei, Wang, Gang, Bi, Ying, Jiang, Zhihang, Wang, Xiaofei
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.11.2022
• Subjects: B cell subsets; CB839; Glutamine metabolism; Lupus nephritis; mTOR pathway; NLRP3 pathway; Systemic lupus erythematosus; T cell subsets; CB839; Systemic lupus erythematosus; Glutamine metabolism; mTOR pathway; NLRP3 pathway; Lupus nephritis; B cell subsets; T cell subsets

•Herein, intracellular glutamine metabolism level in lupus was revealed.•In this study, a direct detection of intracellular metabolites was used to evaluate the glutamine metabolism level, avoiding the metabolic environmental difference between in vitro culture and in vivo and reflected a more intui...