Potential surgical targets for deep brain stimulation in treatment-resistant depression

• Published in: Neurosurgical focus Vol. 25; no. 1; p. E3
• Main Authors: Hauptman, Jason S, DeSalles, Antonio A F, Espinoza, Randall, Sedrak, Mark, Ishida, Warren
• Format: Journal Article
• Language: English
• Published: United States 2008
• Subjects: Animals; Brain - anatomy & histology; Brain - physiopathology; Brain - surgery; Deep Brain Stimulation - methods; Deep Brain Stimulation - standards; Deep Brain Stimulation - trends; Depressive Disorder - pathology; Depressive Disorder - physiopathology; Depressive Disorder - surgery; Drug Resistance - physiology; Gyrus Cinguli - anatomy & histology; Gyrus Cinguli - physiopathology; Gyrus Cinguli - surgery; Habenula - anatomy & histology; Habenula - physiopathology; Habenula - surgery; Humans; Limbic System - anatomy & histology; Limbic System - physiopathology; Limbic System - surgery; Nerve Net - pathology; Nerve Net - physiopathology; Nerve Net - surgery; Nucleus Accumbens - anatomy & histology; Nucleus Accumbens - physiopathology; Nucleus Accumbens - surgery; Treatment Outcome

The goal of this study was to evaluate the definition of treatment-resistant depression (TRD), review the literature regarding deep brain stimulation (DBS) for TRD, and identify potential anatomical and functional targets for future widespread clinical application. A comprehensive literature review...