Mobilization of tumour cells during biopsy in an infant with Ewing sarcoma
Ewing sarcoma and the closely related peripheral primitive neuroectodermal tumour, recently referred to as Ewing tumour (ET), are characterised by unique gene rearrangements on chromosome 22. The breakpoints have been cloned and shown to fuse the Ewing sarcoma gene to one of two closely related ETS...
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Published in | European journal of pediatrics Vol. 155; no. 5; pp. 373 - 376 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Heidelberg
Springer
01.05.1996
Berlin Springer Nature B.V |
Subjects | |
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Abstract | Ewing sarcoma and the closely related peripheral primitive neuroectodermal tumour, recently referred to as Ewing tumour (ET), are characterised by unique gene rearrangements on chromosome 22. The breakpoints have been cloned and shown to fuse the Ewing sarcoma gene to one of two closely related ETS proto-oncogens, FLI-1 or ERG, which reside on chromosomes 11 and 21, respectively. The rearrangement results in the expression of specific hybrid transcripts which can be detected with high sensitivity by the reverse transcriptase polymerase chain reaction technique (RT-PCR) in primary tumours, blood and bone marrow. We report on a 7-month-old boy with a pelvic Ewing sarcoma in whom circulating tumour cells were identified in the peripheral blood during open tumour biopsy by RT-PCR. However, before and 6 days after surgery no tumour cells could be detected in the peripheral blood.
The application of RT-PCR to monitor shedding of tumour cells during surgical intervention will help to evaluate if open biopsy potentially contributes to metastatic tumour cell spread. |
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AbstractList | Ewing sarcoma and the closely relate peripheral primitive neuroectodermal tumour, recently referred to as Ewing tumour (ET), are characterised by unique gene rearrangements on chromosome 22. The breakpoints have been cloned and shown to fuse the Ewing sarcoma gene to one of two closely related ETS proto-oncogens, FLI-1 or ERG, which reside on chromosomes 11 and 21, respectively. The rearrangement results in the expression of specific hybrid transcripts which can be detected with high sensitivity by the reverse transcriptase polymerase chain reaction technique (RT-PCR) in primary tumours, blood and bone marrow. We report on a 7-month-old boy with a pelvic Ewing sarcoma in whom circulating tumour cells were identified in the peripheral blood during open tumour biopsy by RT-PCR. However, before and 6 days after surgery no tumour cells could be detected in the peripheral blood. The application of RTPCR to monito shedding of tumour cells during surgical intervention will nelp to evaluate if open biopsy potentially contributes to metastatic tumour cell spread. UNLABELLEDEwing sarcoma and the closely related peripheral primitive neuroectodermal tumour, recently referred to as Ewing tumour (ET), are characterised by unique gene rearrangements on chromosome 22. The breakpoints have been cloned and shown to fuse the Ewing sarcoma gene to one of two closely related ETS proto-oncogens, FLI-1 or ERG, which reside on chromosomes 11 and 21, respectively. The rearrangement results in the expression of specific hybrid transcripts which can be detected with high sensitivity by the reverse transcriptase polymerase chain reaction technique (RT-PCR) in primary tumours, blood and bone marrow. We report on a 7-month-old boy with a pelvic Ewing sarcoma in whom circulating tumour cells were identified in the peripheral blood during open tumour biopsy by RT-PCR. However, before and 6 days after surgery no tumour cells could be detected in the peripheral blood. CONCLUSIONThe application of RT-PCR to monitor shedding of tumour cells during surgical intervention will help to evaluate if open biopsy potentially contributes to metastatic tumour cell spread. Ewing sarcoma and the closely related peripheral primitive neuroectodermal tumour, recently referred to as Ewing tumour (ET), are characterised by unique gene rearrangements on chromosome 22. The breakpoints have been cloned and shown to fuse the Ewing sarcoma gene to one of two closely related ETS proto-oncogens, FLI-1 or ERG, which reside on chromosomes 11 and 21, respectively. The rearrangement results in the expression of specific hybrid transcripts which can be detected with high sensitivity by the reverse transcriptase polymerase chain reaction technique (RT-PCR) in primary tumours, blood and bone marrow. We report on a 7-month-old boy with a pelvic Ewing sarcoma in whom circulating tumour cells were identified in the peripheral blood during open tumour biopsy by RT-PCR. However, before and 6 days after surgery no tumour cells could be detected in the peripheral blood. The application of RT-PCR to monitor shedding of tumour cells during surgical intervention will help to evaluate if open biopsy potentially contributes to metastatic tumour cell spread. |
Author | KRONBERGER, M WINDHAGER, R GRUBER, B AMANN, G GADNER, H ZOUBEK, A KOVAR, H |
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Cites_doi | 10.1002/1097-0142(19940801)74:3<988::AID-CNCR2820740334>3.0.CO;2-Z 10.1182/blood.V83.3.636.636 10.1002/ijc.2910640211 10.1200/JCO.1994.12.12.2634 10.1038/359162a0 10.1182/blood.V82.9.2605.2605 10.1056/NEJM199101243240403 10.1056/NEJM199408043310503 10.1002/1097-0142(19880101)61:1<23::AID-CNCR2820610106>3.0.CO;2-M 10.1016/S0039-6060(05)80235-1 10.1056/NEJM199402033300507 10.1093/jnci/87.5.385 10.1002/ijc.2910570510 10.1038/bjc.1995.283 10.1056/NEJM199003013220907 10.1038/bjc.1994.419 10.1055/s-2008-1046548 |
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Keywords | Human Ewing sarcoma Diseases of the osteoarticular system Reverse transcription Exploration Infant Malignant tumor Blood Polymerase chain reaction Biopsy Bone Molecular biology Tumor cell Blood dissemination |
Language | English |
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References | LA Liotta (BF01955264_CR12) 1974; 34 AA Ross (BF01955264_CR16) 1993; 82 M Peter (BF01955264_CR14) 1995; 72 A Zoubek (BF01955264_CR20) 1994; 70 O Delattre (BF01955264_CR6) 1992; 359 ME Horowitz (BF01955264_CR10) 1993 H Jürgens (BF01955264_CR11) 1988; 61 SA Burchill (BF01955264_CR3) 1994; 57 A Zoubek (BF01955264_CR21) 1995; 207 C Pfleiderer (BF01955264_CR15) 1995; 64 BR Zetter (BF01955264_CR19) 1990; 322 B Dockhorn-Dworniczak (BF01955264_CR9) 1994; 74 MJ Cline (BF01955264_CR5) 1994; 330 TJ Moss (BF01955264_CR13) 1991; 324 MV Seiden (BF01955264_CR17) 1994; 12 DC Brown (BF01955264_CR1) 1995; 117 JA Toretzky (BF01955264_CR18) 1995; 87 A Dobrovic (BF01955264_CR8) 1995; 36 W Brugger (BF01955264_CR2) 1994; 83 P Chomezynski (BF01955264_CR4) 1987; 162 O Delattre (BF01955264_CR7) 1994; 331 |
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Snippet | Ewing sarcoma and the closely related peripheral primitive neuroectodermal tumour, recently referred to as Ewing tumour (ET), are characterised by unique gene... Ewing sarcoma and the closely relate peripheral primitive neuroectodermal tumour, recently referred to as Ewing tumour (ET), are characterised by unique gene... UNLABELLEDEwing sarcoma and the closely related peripheral primitive neuroectodermal tumour, recently referred to as Ewing tumour (ET), are characterised by... |
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SubjectTerms | Base Sequence Biological and medical sciences Biopsy Bone marrow Bone Neoplasms - blood Bone Neoplasms - genetics Bone Neoplasms - pathology Bone Neoplasms - surgery Bone tumors Breakpoints Chromosome 22 Ewing's sarcoma Ewings sarcoma FLI-1 protein Hematologic and hematopoietic diseases Humans Infant Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Metastases Molecular Sequence Data Neoplasm Metastasis Neoplastic Cells, Circulating Pelvis Peripheral blood Polymerase Chain Reaction RNA-directed DNA polymerase Sarcoma, Ewing - blood Sarcoma, Ewing - genetics Sarcoma, Ewing - pathology Sarcoma, Ewing - surgery Surgery Transcription, Genetic |
Title | Mobilization of tumour cells during biopsy in an infant with Ewing sarcoma |
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