Effect of the Platelet Activating Factor Antagonist BN52021 in Rabbits: Role in Gentamicin Nephrotoxicity

• Published in: Toxicology and applied pharmacology Vol. 128; no. 1; pp. 111 - 115
• Main Authors: Hanslik, T., Blanchet, F., Nochy, D., Pirotzky, E., Guilmard, C., Seta, N., Carbon, C.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.1994
• Subjects: Animals; Diterpenes; Dose-Response Relationship, Drug; Electrolytes - urine; Gentamicins - administration & dosage; Gentamicins - toxicity; Ginkgolides; Glomerular Filtration Rate - drug effects; Injections, Subcutaneous; Kidney - blood supply; Kidney - drug effects; Kidney - metabolism; Kidney Function Tests; Lactones - administration & dosage; Lactones - pharmacology; Male; Models, Biological; Platelet Activating Factor - antagonists & inhibitors; Platelet Activating Factor - physiology; Rabbits

Platelet activating factor (PAF) is an ubiquitous phospholipid that acts as a mediator of numerous pathophysiological conditions, including drug nephrotoxicity. Aminoglycosides are potent antibiotics but their use is limited by their nephrotoxic potential. We assumed that PAF could participate in in...