Identification of three metallothioneins in the black soldier fly and their functions in Cd accumulation and detoxification
The black soldier fly (BSF) Hermetia illucens has a strong tolerance to cadmium stress. This helps to use BSF in entomoremediation of heavy metal pollution. Rich metallothionein (MT) proteins were thought to be important for some insects to endure the toxicity of heavy metal. We identified and chara...
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| Published in | Environmental pollution (1987) Vol. 286; p. 117146 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
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Elsevier Ltd
01.10.2021
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| Subjects | |
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| Abstract | The black soldier fly (BSF) Hermetia illucens has a strong tolerance to cadmium stress. This helps to use BSF in entomoremediation of heavy metal pollution. Rich metallothionein (MT) proteins were thought to be important for some insects to endure the toxicity of heavy metal. We identified and characterized three MTs genes in BSF (BSFMTs), including BSFMT1, BSFMT2A, and BSFMT2B. Molecular modeling was used to predict metal binding sites. Phylogenetic analysis was used to identify gene families. Overexpression of the recombinant black soldier fly metallothioneins was found to confer Cd tolerance in Escherichia coli. Finally, functions of BSFMTs in BSF were explored through RNA interference (RNAi). RNAi results of BSFMT2B showed that the larval fresh weight decreased significantly, and the larvae mortality increased significantly. This study suggests that BSFMTs have important properties in Cd detoxification and tolerance in BSF. Further characterization analyses of physiological function about metallothioneins are necessary in BSF and other insects.
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•There are three BSFMTs in H. illucens which are rich in the gut and malpighian tubules.•Metal binding sites of BSFMTs are more than other insects.•BSFMTs expression level changed in response to Cd concentrations.•Overexpression of recombinant BSFMTs enhanced Cd tolerance in Escherichia coli.•RNAi of BSFMTs provided their function in Cd detoxification and tolerance.
BSFMTs which show Cd detoxification and tolerance can be used in entomoremediation of heavy metal pollution. |
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| AbstractList | The black soldier fly (BSF) Hermetia illucens has a strong tolerance to cadmium stress. This helps to use BSF in entomoremediation of heavy metal pollution. Rich metallothionein (MT) proteins were thought to be important for some insects to endure the toxicity of heavy metal. We identified and characterized three MTs genes in BSF (BSFMTs), including BSFMT1, BSFMT2A, and BSFMT2B. Molecular modeling was used to predict metal binding sites. Phylogenetic analysis was used to identify gene families. Overexpression of the recombinant black soldier fly metallothioneins was found to confer Cd tolerance in Escherichia coli. Finally, functions of BSFMTs in BSF were explored through RNA interference (RNAi). RNAi results of BSFMT2B showed that the larval fresh weight decreased significantly, and the larvae mortality increased significantly. This study suggests that BSFMTs have important properties in Cd detoxification and tolerance in BSF. Further characterization analyses of physiological function about metallothioneins are necessary in BSF and other insects.
[Display omitted]
•There are three BSFMTs in H. illucens which are rich in the gut and malpighian tubules.•Metal binding sites of BSFMTs are more than other insects.•BSFMTs expression level changed in response to Cd concentrations.•Overexpression of recombinant BSFMTs enhanced Cd tolerance in Escherichia coli.•RNAi of BSFMTs provided their function in Cd detoxification and tolerance.
BSFMTs which show Cd detoxification and tolerance can be used in entomoremediation of heavy metal pollution. |
| ArticleNumber | 117146 |
| Author | Wen, Yiting Zhu, Fen Gao, Zhenghui Wang, Wanqiang Zhang, Jie Shi, Zhihui Liu, Wen Wang, Xiaoping |
| Author_xml | – sequence: 1 givenname: Jie surname: Zhang fullname: Zhang, Jie email: jiezhangzf@webmail.hzau.edu.cn organization: Hubei International Scientific and Technological Cooperation Base of Waste Conversion By Insects, Huazhong Agricultural University, Wuhan, 430070, China – sequence: 2 givenname: Zhihui surname: Shi fullname: Shi, Zhihui email: zhihuishi@webmail.hzau.edu.cn organization: Hubei International Scientific and Technological Cooperation Base of Waste Conversion By Insects, Huazhong Agricultural University, Wuhan, 430070, China – sequence: 3 givenname: Zhenghui surname: Gao fullname: Gao, Zhenghui email: zhgao@webmail.hzau.edu.cn organization: Hubei International Scientific and Technological Cooperation Base of Waste Conversion By Insects, Huazhong Agricultural University, Wuhan, 430070, China – sequence: 4 givenname: Yiting surname: Wen fullname: Wen, Yiting email: ytwen@webmail.hzau.edu.cn organization: Hubei International Scientific and Technological Cooperation Base of Waste Conversion By Insects, Huazhong Agricultural University, Wuhan, 430070, China – sequence: 5 givenname: Wanqiang surname: Wang fullname: Wang, Wanqiang email: wanqiangwang@webmail.hzau.edu.cn organization: Hubei International Scientific and Technological Cooperation Base of Waste Conversion By Insects, Huazhong Agricultural University, Wuhan, 430070, China – sequence: 6 givenname: Wen surname: Liu fullname: Liu, Wen email: liuwen@mail.hzau.edu.cn organization: Hubei Insect Resources Utilization and Sustainable Pest Management Key Laboratory, Huazhong Agricultural University, Wuhan, 430070, China – sequence: 7 givenname: Xiaoping surname: Wang fullname: Wang, Xiaoping email: xpwang@mail.hzau.edu.cn organization: Hubei Insect Resources Utilization and Sustainable Pest Management Key Laboratory, Huazhong Agricultural University, Wuhan, 430070, China – sequence: 8 givenname: Fen orcidid: 0000-0003-3909-0923 surname: Zhu fullname: Zhu, Fen email: zhufen@mail.hzau.edu.cn organization: Hubei International Scientific and Technological Cooperation Base of Waste Conversion By Insects, Huazhong Agricultural University, Wuhan, 430070, China |
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| Cites_doi | 10.1038/nmeth.3213 10.1371/journal.pone.0216086 10.1007/s11356-017-8550-3 10.1016/j.aquatox.2013.05.004 10.1002/cptx.17 10.1016/j.aquatox.2010.04.004 10.3390/toxins11080476 10.1007/s00775-011-0825-4 10.1007/s00018-002-8454-2 10.1016/j.bbrc.2014.02.055 10.15517/rbt.v64i2.18484 10.1016/j.jhazmat.2012.07.027 10.1016/j.envpol.2018.06.105 10.1016/j.jmb.2009.01.035 10.1002/jsfa.8702 10.1016/S0378-1119(01)00577-7 10.1371/journal.pone.0221420 10.1002/jemt.22919 10.1016/j.gene.2005.07.026 10.1371/journal.pone.0166186 10.1016/j.jclepro.2019.05.074 10.1039/C6FO01580H 10.1039/c2mt20081c 10.1104/pp.113.215681 10.3920/JIFF2015.0030 10.1038/40785 10.1186/2193-1801-3-280 10.1002/jat.3454 10.1128/MCB.26.6.2286-2296.2006 10.3390/toxins11090532 10.1016/j.cbpb.2011.06.008 10.1039/C8MT00165K 10.1016/j.ecoenv.2018.08.089 10.1016/j.jprot.2017.05.017 10.3389/fpls.2018.01388 10.1111/mec.14984 10.1016/j.scitotenv.2018.03.252 10.1007/s10661-015-4436-3 10.1038/s41598-019-46603-z 10.1016/S0742-8413(99)00087-0 10.3390/biom4020435 10.1016/j.copbio.2005.02.006 10.1093/emboj/cdg012 10.3390/ijms17091483 10.1093/bioinformatics/btt447 10.1016/j.envpol.2003.09.012 10.1016/j.jinorgbio.2016.11.017 10.1016/S0014-5793(00)01149-2 |
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| Keywords | Black soldier fly Cd detoxification Cadmium (Cd) accumulation Metallothioneins |
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| References | He, Li, Luo, Ma, Li, Qu, Gai, Jiang, Janz, Polle, Tyree, Luo (bib22) 2013; 162 Ziller, Fraissinet-Tachet (bib54) 2018; 10 Cai, Ma, Hu, Tomberlin, Yu, Huang, Zhan, Li, Zheng, Yu, Zhang (bib7) 2018; 242 Moltó, Bonzón-Kulichenko, del Arco, López-Alañón, Carrillo, Gallardo, Andrés (bib37) 2005; 361 van der Fels-Klerx, Camenzuli, van der Lee, Oonincx (bib49) 2016; 11 Tang, Huang, Zhang, Wu, Murphy, Liu (bib45) 2011; 160 Xiang, Zhu, Jin, Hu, Tan, Yang (bib50) 2013; 140–141 Guo, Gao, Cao, Jiang, Liu, Liu, Chen, Zhou, Cui, Wang (bib21) 2019 Isani, Carpene (bib27) 2014; 4 Leni, Cirlini, Jacobs, Depraetere, Gianotten, Sforza, Dall'Asta (bib29) 2019; 11 Shen, Zhao, Qiao, Liu, Wang, Cao, Li, Zhao (bib43) 2015; 10 Bhandari, Melchiorre, Dostie, Laukens, Devisscher, Louwrier, Thees, Lynes (bib4) 2017; 71 Gao, Wang, Wang, Lei, Zhu (bib16) 2017; 24 Meijer, Stoopen, van der Fels-Klerx, van Loon, Carney, Bosch (bib35) 2019; 11 Bulak, Polakowski, Nowak, Waśko, Wiącek, Bieganowski (bib6) 2018; 633 Egli, Selvaraj, Yepiskoposyan, Zhang, Hafen, Georgiev, Schaffner (bib12) 2003; 22 Ojo, Adewumi, Oluwatoyin (bib38) 2016; 64 Purac, Nikolic, Kojic, Celic, Plavsa, Blagojevic, Petri (bib40) 2019; 28 Diener, Zurbruegg, Tockner (bib10) 2015; 1 Mohanty (bib36) 2016; 6 Dallinger, Berger, Hunziger, Kgi (bib9) 1997; 388 Maremanda, Khan, Jena (bib34) 2014; 445 Ai, Naing, Yun, Lim, Kim (bib1) 2018; 9 Ling, Wei, Wang, Kong, Wu, Guo, Li, Li (bib31) 2016; 17 Giglio, Brandmayr (bib20) 2017; 37 Gao, Wang, Wang, Lei, Zhu (bib17) 2017; 24 Huang, Gong, Shen, He, Fu, Wang, Tan, Xu, Yang (bib25) 2018; 165 Biancarosa, Liland, Biemans, Araujo, Bruckner, Waagbo, Torstensen, Lock, Amlund (bib5) 2018; 98 Sas-Nowosielska, Kucharski, Małkowski, Pogrzeba, Kuperberg, Kryński (bib42) 2004; 128 Shumo, Osuga, Khamis, Tanga, Fiaboe, Subramanian, Ekesi, van Huis, Borgemeister (bib44) 2019; 9 Gall, Boyd, Rajakaruna (bib14) 2015; 187 Peroza, Schmucki, Guntert, Freisinger, Zerbe (bib39) 2009; 387 Huang, Wang (bib24) 2010; 99 Gao, Deng, Zhu (bib18) 2019; 14 Babula, Masarik, Adam, Eckschlager, Stiborova, Trnkova, Skutkova, Provaznik, Hubalek, Kizek (bib3) 2012; 4 Coyle, Philcox, Carey, Rofe (bib8) 2002; 59 Yang, Roy, Zhang (bib52) 2013; 29 Valls, Bofill, Romero-Isart, Gonzalez-Duarte, Abian, Carrascal, Gonzalez-Duarte, Capdevila, Atrian (bib48) 2000; 467 Ziller, Yadav, Capdevila, Reddy, Vallon, Marmeisse, Atrian, Palacios, Fraissinet-Tachet (bib55) 2017; 167 Yang, Yan, Roy, Xu, Poisson, Zhang (bib51) 2015; 12 Luo, Finet, Cong, Wei, Chung (bib33) 2020; 287 Kraemer (bib28) 2005; 16 Hensbergen, van Velzen, Adi Nugroho, Donker, van Straalen (bib23) 2000; 125 Huang, He, Shen, Guo, Mubeen, Yuan, Yang (bib26) 2017; 8 Salvaggio, Pecoraro, Scalisi, Tibullo, Lombardo, Messina, Loreto, Copat, Ferrante, Avola, D'amante, Genovese, Raccuia, Brundo (bib41) 2017; 80 Gao, Deng, Gao, Li, Liu, Wang, Zhu (bib15) 2019; 14 Egli, Yepiskoposyan, Selvaraj, Balamurugan, Rajaram, Simons, Multhaup, Mettler, Vardanyan, Georgiev, Schaffner (bib13) 2006; 26 Atanesyan, Gunther, Celniker, Georgiev, Schaffner (bib2) 2011; 16 Lim, Mohd-Noor, Wong, Lam, Goh, Beniers, Oh, Jumbri, Abd Ghani (bib30) 2019; 231 Zheng, Xie, Wang, Lin (bib53) 2017; 164 Douchiche, Chaïbi, Morvan (bib11) 2012; 235–236 Gao, Wang, Lu, Zhu, Liu, Wang, Lei (bib19) 2019; 230 Liu, Wu, Kou, Liu, Zhang, Guo, Ma (bib32) 2014; 9 Tzuc, Escalante, Rojas Herrera, Gaxiola Cortés, Ortiz (bib47) 2014; 3 Tanguy, Moraga (bib46) 2001; 273 He (10.1016/j.envpol.2021.117146_bib22) 2013; 162 Yang (10.1016/j.envpol.2021.117146_bib52) 2013; 29 Peroza (10.1016/j.envpol.2021.117146_bib39) 2009; 387 Sas-Nowosielska (10.1016/j.envpol.2021.117146_bib42) 2004; 128 Mohanty (10.1016/j.envpol.2021.117146_bib36) 2016; 6 Hensbergen (10.1016/j.envpol.2021.117146_bib23) 2000; 125 Huang (10.1016/j.envpol.2021.117146_bib26) 2017; 8 Diener (10.1016/j.envpol.2021.117146_bib10) 2015; 1 Egli (10.1016/j.envpol.2021.117146_bib12) 2003; 22 Liu (10.1016/j.envpol.2021.117146_bib32) 2014; 9 Bhandari (10.1016/j.envpol.2021.117146_bib4) 2017; 71 Gao (10.1016/j.envpol.2021.117146_bib19) 2019; 230 Guo (10.1016/j.envpol.2021.117146_bib21) 2019 Huang (10.1016/j.envpol.2021.117146_bib25) 2018; 165 Yang (10.1016/j.envpol.2021.117146_bib51) 2015; 12 Xiang (10.1016/j.envpol.2021.117146_bib50) 2013; 140–141 Tanguy (10.1016/j.envpol.2021.117146_bib46) 2001; 273 Shen (10.1016/j.envpol.2021.117146_bib43) 2015; 10 Douchiche (10.1016/j.envpol.2021.117146_bib11) 2012; 235–236 Meijer (10.1016/j.envpol.2021.117146_bib35) 2019; 11 Salvaggio (10.1016/j.envpol.2021.117146_bib41) 2017; 80 Gao (10.1016/j.envpol.2021.117146_bib18) 2019; 14 Moltó (10.1016/j.envpol.2021.117146_bib37) 2005; 361 van der Fels-Klerx (10.1016/j.envpol.2021.117146_bib49) 2016; 11 Atanesyan (10.1016/j.envpol.2021.117146_bib2) 2011; 16 Purac (10.1016/j.envpol.2021.117146_bib40) 2019; 28 Gao (10.1016/j.envpol.2021.117146_bib16) 2017; 24 Biancarosa (10.1016/j.envpol.2021.117146_bib5) 2018; 98 Ling (10.1016/j.envpol.2021.117146_bib31) 2016; 17 Gall (10.1016/j.envpol.2021.117146_bib14) 2015; 187 Kraemer (10.1016/j.envpol.2021.117146_bib28) 2005; 16 Gao (10.1016/j.envpol.2021.117146_bib15) 2019; 14 Tzuc (10.1016/j.envpol.2021.117146_bib47) 2014; 3 Dallinger (10.1016/j.envpol.2021.117146_bib9) 1997; 388 Babula (10.1016/j.envpol.2021.117146_bib3) 2012; 4 Huang (10.1016/j.envpol.2021.117146_bib24) 2010; 99 Bulak (10.1016/j.envpol.2021.117146_bib6) 2018; 633 Tang (10.1016/j.envpol.2021.117146_bib45) 2011; 160 Ziller (10.1016/j.envpol.2021.117146_bib54) 2018; 10 Valls (10.1016/j.envpol.2021.117146_bib48) 2000; 467 Gao (10.1016/j.envpol.2021.117146_bib17) 2017; 24 Ojo (10.1016/j.envpol.2021.117146_bib38) 2016; 64 Shumo (10.1016/j.envpol.2021.117146_bib44) 2019; 9 Egli (10.1016/j.envpol.2021.117146_bib13) 2006; 26 Lim (10.1016/j.envpol.2021.117146_bib30) 2019; 231 Zheng (10.1016/j.envpol.2021.117146_bib53) 2017; 164 Ziller (10.1016/j.envpol.2021.117146_bib55) 2017; 167 Ai (10.1016/j.envpol.2021.117146_bib1) 2018; 9 Maremanda (10.1016/j.envpol.2021.117146_bib34) 2014; 445 Luo (10.1016/j.envpol.2021.117146_bib33) 2020; 287 Coyle (10.1016/j.envpol.2021.117146_bib8) 2002; 59 Giglio (10.1016/j.envpol.2021.117146_bib20) 2017; 37 Cai (10.1016/j.envpol.2021.117146_bib7) 2018; 242 Isani (10.1016/j.envpol.2021.117146_bib27) 2014; 4 Leni (10.1016/j.envpol.2021.117146_bib29) 2019; 11 |
| References_xml | – volume: 16 start-page: 1047 year: 2011 end-page: 1056 ident: bib2 article-title: Characterization of MtnE, the fifth metallothionein member in publication-title: J. Biol. Inorg. Chem. contributor: fullname: Schaffner – volume: 231 start-page: 129 year: 2019 end-page: 136 ident: bib30 article-title: Palatability of black soldier fly larvae in valorizing mixed waste coconut endosperm and soybean curd residue into larval lipid and protein sources publication-title: J. Environ. Manag. contributor: fullname: Abd Ghani – volume: 388 start-page: 237 year: 1997 end-page: 238 ident: bib9 article-title: Metallothionein in snail Cd and Cu metabolism publication-title: Nature contributor: fullname: Kgi – volume: 99 start-page: 86 year: 2010 end-page: 92 ident: bib24 article-title: Expression and characterization analysis of type 2 metallothionein from grey mangrove species ( publication-title: Aquat. Toxicol. contributor: fullname: Wang – volume: 59 start-page: 627 year: 2002 end-page: 647 ident: bib8 article-title: Metallothionein: the multipurpose protein publication-title: Cell. Mol. Life Sci. contributor: fullname: Rofe – volume: 9 start-page: 13 year: 2019 ident: bib44 article-title: The nutritive value of black soldier fly larvae reared on common organic waste streams in Kenya publication-title: Sci. Rep. contributor: fullname: Borgemeister – volume: 22 start-page: 100 year: 2003 end-page: 108 ident: bib12 article-title: Knockout of 'metal-responsive transcription factor' MTF-1 in publication-title: EMBO J. contributor: fullname: Schaffner – volume: 633 start-page: 912 year: 2018 end-page: 919 ident: bib6 article-title: as a new and promising species for use in entomoremediation publication-title: Sci. Total Environ. contributor: fullname: Bieganowski – volume: 187 start-page: 21 year: 2015 ident: bib14 article-title: Transfer of heavy metals through terrestrial food webs: a review publication-title: Environ. Monit. Assess. contributor: fullname: Rajakaruna – volume: 98 start-page: 2176 year: 2018 end-page: 2183 ident: bib5 article-title: Uptake of heavy metals and arsenic in black soldier fly ( publication-title: J. Sci. Food Agric. contributor: fullname: Amlund – volume: 37 start-page: 889 year: 2017 end-page: 894 ident: bib20 article-title: Structural and functional alterations in Malpighian tubules as biomarkers of environmental pollution: synopsis and prospective publication-title: J. Appl. Toxicol. contributor: fullname: Brandmayr – volume: 11 year: 2019 ident: bib29 article-title: Impact of naturally contaminated substrates on publication-title: Toxins contributor: fullname: Dall'Asta – volume: 26 start-page: 2286 year: 2006 end-page: 2296 ident: bib13 article-title: A family knockout of all four publication-title: Mol. Cell Biol. contributor: fullname: Schaffner – volume: 12 start-page: 7 year: 2015 ident: bib51 article-title: The I-TASSER Suite: protein structure and function prediction publication-title: Nat. Methods contributor: fullname: Zhang – volume: 235–236 start-page: 101 year: 2012 end-page: 107 ident: bib11 article-title: Cadmium tolerance and accumulation characteristics of mature flax, cv. Hermes: contribution of the basal stem compared to the root publication-title: J. Hazard Mater. contributor: fullname: Morvan – volume: 242 start-page: 634 year: 2018 end-page: 642 ident: bib7 article-title: Systematic characterization and proposed pathway of tetracycline degradation in solid waste treatment by publication-title: Environ. Pollut. contributor: fullname: Zhang – volume: 164 start-page: 85 year: 2017 end-page: 93 ident: bib53 article-title: Determination of the protein expression profiles of publication-title: J. Proteom. contributor: fullname: Lin – volume: 9 year: 2018 ident: bib1 article-title: Overexpression of RsMYB1 enhances anthocyanin accumulation and heavy metal stress tolerance in Transgenic Petunia publication-title: Front. Plant Sci. contributor: fullname: Kim – volume: 24 start-page: 1 year: 2017 end-page: 8 ident: bib16 article-title: Influences of chromium and cadmium on the development of black soldier fly larvae publication-title: Environ. Sci. Pollut. Res. contributor: fullname: Zhu – volume: 80 start-page: 1215 year: 2017 end-page: 1220 ident: bib41 article-title: Morphostructural and immunohistochemical study on the role of metallothionein in the detoxification of heavy metals in publication-title: Microsc. Res. Tech. contributor: fullname: Brundo – volume: 16 start-page: 133 year: 2005 end-page: 141 ident: bib28 article-title: Phytoremediation: novel approaches to cleaning up polluted soils publication-title: Curr. Opin. Biotechnol. contributor: fullname: Kraemer – volume: 230 start-page: 974 year: 2019 end-page: 980 ident: bib19 article-title: Bioconversion performance and life table of black soldier fly ( publication-title: J. Clean. Prod. contributor: fullname: Lei – volume: 162 start-page: 424 year: 2013 ident: bib22 article-title: A transcriptomic network underlies microstructural and physiological responses to cadmium in publication-title: Plant Physiol. contributor: fullname: Luo – volume: 387 start-page: 207 year: 2009 end-page: 218 ident: bib39 article-title: The beta (e)-domain of wheat e-c-1 metallothionein: a metal-binding domain with a distinctive structure publication-title: J. Mol. Biol. contributor: fullname: Zerbe – volume: 29 start-page: 2588 year: 2013 end-page: 2595 ident: bib52 article-title: Protein-ligand binding site recognition using complementary binding-specific substructure comparison and sequence profile alignment publication-title: Bioinformatics contributor: fullname: Zhang – volume: 71 start-page: 17 year: 2017 end-page: 19 ident: bib4 article-title: Detection and manipulation of the stress response protein metallothionein publication-title: Curr. Protocols Toxicol. contributor: fullname: Lynes – volume: 165 start-page: 450 year: 2018 end-page: 458 ident: bib25 article-title: Cloning, characterization and expression analysis of metallothioneins from publication-title: Ecotoxicol. Environ. Saf. contributor: fullname: Yang – volume: 14 year: 2019 ident: bib18 article-title: Reference gene selection for quantitative gene expression analysis in black soldier fly ( publication-title: PloS One contributor: fullname: Zhu – volume: 287 year: 2020 ident: bib33 article-title: The evolution of insect metallothioneins publication-title: Proceed. Biol. Sci. contributor: fullname: Chung – volume: 6 start-page: 398 year: 2016 ident: bib36 article-title: Post-harvest management of phytoremediation technology publication-title: J. Environ. Anal. Toxicol. contributor: fullname: Mohanty – volume: 24 start-page: 8637 year: 2017 end-page: 8644 ident: bib17 article-title: Influences of chromium and cadmium on the development of black soldier fly larvae publication-title: Environ. Sci. Pollut. Control Ser. contributor: fullname: Zhu – volume: 160 start-page: 81 year: 2011 end-page: 88 ident: bib45 article-title: Identification of two metallothionein genes and their roles in stress responses of publication-title: Comp. Biochem. Physiol. B Biochem. Mol. Biol. contributor: fullname: Liu – volume: 28 start-page: 731 year: 2019 end-page: 745 ident: bib40 article-title: Identification of a metallothionein gene in honey bee publication-title: Mol. Ecol. contributor: fullname: Petri – volume: 17 start-page: 1483 year: 2016 ident: bib31 article-title: Mammalian metallothionein-2a and oxidative stress publication-title: Int. J. Mol. Sci. contributor: fullname: Li – volume: 9 start-page: 10 year: 2014 ident: bib32 article-title: Two metallothionein genes in publication-title: PloS One contributor: fullname: Ma – volume: 273 start-page: 123 year: 2001 end-page: 130 ident: bib46 article-title: Cloning and characterization of a gene coding for a novel metallothionein in the Pacific Oyster publication-title: Gene contributor: fullname: Moraga – volume: 361 start-page: 140 year: 2005 end-page: 148 ident: bib37 article-title: Cloning, tissue expression and metal inducibility of an ubiquitous metallothionein 11EMBL accession no. MTPA AJ414050. from publication-title: Gene contributor: fullname: Andrés – volume: 125 start-page: 17 year: 2000 end-page: 24 ident: bib23 article-title: Metallothionein-bound cadmium in the gut of the insect publication-title: Comp. Biochem. Physiol. C Pharmacol. Toxicol. Endocrinol. contributor: fullname: van Straalen – volume: 3 year: 2014 ident: bib47 article-title: Microbiota from publication-title: SpringerPlus contributor: fullname: Ortiz – volume: 8 start-page: 1373 year: 2017 end-page: 1401 ident: bib26 article-title: Toxicity of cadmium and its health risks from leafy vegetable consumption publication-title: Food Funct. contributor: fullname: Yang – volume: 4 start-page: 739 year: 2012 end-page: 750 ident: bib3 article-title: Mammalian metallothioneins: properties and functions publication-title: Metallomics contributor: fullname: Kizek – volume: 14 year: 2019 ident: bib15 article-title: Effect of sulfonamide pollution on the growth of manure management candidate publication-title: PloS One contributor: fullname: Zhu – volume: 140–141 start-page: 1 year: 2013 end-page: 10 ident: bib50 article-title: Expression and function analysis of metallothionein in the testis of publication-title: Aquat. Toxicol. contributor: fullname: Yang – volume: 10 year: 2015 ident: bib43 article-title: Identification of Glutathione S-Transferase (GST) genes from a dark septate endophytic fungus ( publication-title: PloS One contributor: fullname: Zhao – volume: 10 start-page: 1549 year: 2018 end-page: 1559 ident: bib54 article-title: Metallothionein diversity and distribution in the tree of life: a multifunctional protein publication-title: Metallomics contributor: fullname: Fraissinet-Tachet – start-page: 1 year: 2019 end-page: 11 ident: bib21 article-title: Phytoremediation of Cd and Pb interactive polluted soils by switchgrass ( publication-title: Int. J. Phytoremediation contributor: fullname: Wang – volume: 128 start-page: 373 year: 2004 end-page: 379 ident: bib42 article-title: Phytoextraction crop disposal—an unsolved problem publication-title: Environ. Pollut. contributor: fullname: Kryński – volume: 167 start-page: 1 year: 2017 end-page: 11 ident: bib55 article-title: Metagenomics analysis reveals a new metallothionein family: sequence and metal-binding features of new environmental cysteine-rich proteins publication-title: J. Inorg. Biochem. contributor: fullname: Fraissinet-Tachet – volume: 4 start-page: 435 year: 2014 end-page: 457 ident: bib27 article-title: Metallothioneins, unconventional proteins from unconventional animals: a long journey from nematodes to mammals publication-title: Biomolecules contributor: fullname: Carpene – volume: 64 start-page: 779 year: 2016 end-page: 789 ident: bib38 article-title: Glutathione-S-transferase production in earthworm (Annelida: eudrilidae) as a tool for heavy metal pollution assessment in abattoir soil publication-title: Rev. Biol. Trop. contributor: fullname: Oluwatoyin – volume: 1 start-page: 261 year: 2015 end-page: 270 ident: bib10 article-title: Bioaccumulation of heavy metals in the black soldier fly, publication-title: J. Insects Food Feed contributor: fullname: Tockner – volume: 445 start-page: 591 year: 2014 end-page: 596 ident: bib34 article-title: Zinc protects cyclophosphamide-induced testicular damage in rat: involvement of metallothionein, tesmin and Nrf2 publication-title: Biochem. Biophys. Res. Commun. contributor: fullname: Jena – volume: 11 year: 2019 ident: bib35 article-title: Aflatoxin b1 conversion by black soldier fly ( publication-title: Toxins contributor: fullname: Bosch – volume: 467 start-page: 189 year: 2000 end-page: 194 ident: bib48 article-title: MTN: a metazoan copper-thionein related to fungal forms publication-title: FEBS Lett. contributor: fullname: Atrian – volume: 11 start-page: 13 year: 2016 ident: bib49 article-title: Uptake of cadmium, lead and arsenic by publication-title: PloS One contributor: fullname: Oonincx – volume: 287 year: 2020 ident: 10.1016/j.envpol.2021.117146_bib33 article-title: The evolution of insect metallothioneins publication-title: Proceed. Biol. Sci. contributor: fullname: Luo – volume: 9 start-page: 10 year: 2014 ident: 10.1016/j.envpol.2021.117146_bib32 article-title: Two metallothionein genes in Oxya chinensis: molecular characteristics, expression patterns and roles in heavy metal stress publication-title: PloS One contributor: fullname: Liu – volume: 12 start-page: 7 year: 2015 ident: 10.1016/j.envpol.2021.117146_bib51 article-title: The I-TASSER Suite: protein structure and function prediction publication-title: Nat. Methods doi: 10.1038/nmeth.3213 contributor: fullname: Yang – volume: 14 year: 2019 ident: 10.1016/j.envpol.2021.117146_bib15 article-title: Effect of sulfonamide pollution on the growth of manure management candidate Hermetia illucens publication-title: PloS One doi: 10.1371/journal.pone.0216086 contributor: fullname: Gao – volume: 24 start-page: 8637 year: 2017 ident: 10.1016/j.envpol.2021.117146_bib17 article-title: Influences of chromium and cadmium on the development of black soldier fly larvae publication-title: Environ. Sci. Pollut. Control Ser. doi: 10.1007/s11356-017-8550-3 contributor: fullname: Gao – volume: 140–141 start-page: 1 year: 2013 ident: 10.1016/j.envpol.2021.117146_bib50 article-title: Expression and function analysis of metallothionein in the testis of Portunus trituberculatus exposed to cadmium publication-title: Aquat. Toxicol. doi: 10.1016/j.aquatox.2013.05.004 contributor: fullname: Xiang – volume: 71 start-page: 17 year: 2017 ident: 10.1016/j.envpol.2021.117146_bib4 article-title: Detection and manipulation of the stress response protein metallothionein publication-title: Curr. Protocols Toxicol. doi: 10.1002/cptx.17 contributor: fullname: Bhandari – volume: 99 start-page: 86 year: 2010 ident: 10.1016/j.envpol.2021.117146_bib24 article-title: Expression and characterization analysis of type 2 metallothionein from grey mangrove species (Avicennia marina) in response to metal stress publication-title: Aquat. Toxicol. doi: 10.1016/j.aquatox.2010.04.004 contributor: fullname: Huang – volume: 11 year: 2019 ident: 10.1016/j.envpol.2021.117146_bib29 article-title: Impact of naturally contaminated substrates on Alphitobius diaperinus and Hermetia illucens: uptake and excretion of mycotoxins publication-title: Toxins doi: 10.3390/toxins11080476 contributor: fullname: Leni – volume: 16 start-page: 1047 year: 2011 ident: 10.1016/j.envpol.2021.117146_bib2 article-title: Characterization of MtnE, the fifth metallothionein member in Drosophila publication-title: J. Biol. Inorg. Chem. doi: 10.1007/s00775-011-0825-4 contributor: fullname: Atanesyan – volume: 59 start-page: 627 year: 2002 ident: 10.1016/j.envpol.2021.117146_bib8 article-title: Metallothionein: the multipurpose protein publication-title: Cell. Mol. Life Sci. doi: 10.1007/s00018-002-8454-2 contributor: fullname: Coyle – volume: 24 start-page: 1 year: 2017 ident: 10.1016/j.envpol.2021.117146_bib16 article-title: Influences of chromium and cadmium on the development of black soldier fly larvae publication-title: Environ. Sci. Pollut. Res. doi: 10.1007/s11356-017-8550-3 contributor: fullname: Gao – volume: 445 start-page: 591 year: 2014 ident: 10.1016/j.envpol.2021.117146_bib34 article-title: Zinc protects cyclophosphamide-induced testicular damage in rat: involvement of metallothionein, tesmin and Nrf2 publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2014.02.055 contributor: fullname: Maremanda – volume: 64 start-page: 779 year: 2016 ident: 10.1016/j.envpol.2021.117146_bib38 article-title: Glutathione-S-transferase production in earthworm (Annelida: eudrilidae) as a tool for heavy metal pollution assessment in abattoir soil publication-title: Rev. Biol. Trop. doi: 10.15517/rbt.v64i2.18484 contributor: fullname: Ojo – volume: 235–236 start-page: 101 year: 2012 ident: 10.1016/j.envpol.2021.117146_bib11 article-title: Cadmium tolerance and accumulation characteristics of mature flax, cv. Hermes: contribution of the basal stem compared to the root publication-title: J. Hazard Mater. doi: 10.1016/j.jhazmat.2012.07.027 contributor: fullname: Douchiche – volume: 242 start-page: 634 year: 2018 ident: 10.1016/j.envpol.2021.117146_bib7 article-title: Systematic characterization and proposed pathway of tetracycline degradation in solid waste treatment by Hermetia illucens with intestinal microbiota publication-title: Environ. Pollut. doi: 10.1016/j.envpol.2018.06.105 contributor: fullname: Cai – volume: 387 start-page: 207 year: 2009 ident: 10.1016/j.envpol.2021.117146_bib39 article-title: The beta (e)-domain of wheat e-c-1 metallothionein: a metal-binding domain with a distinctive structure publication-title: J. Mol. Biol. doi: 10.1016/j.jmb.2009.01.035 contributor: fullname: Peroza – volume: 98 start-page: 2176 year: 2018 ident: 10.1016/j.envpol.2021.117146_bib5 article-title: Uptake of heavy metals and arsenic in black soldier fly (Hermetia illucens) larvae grown on seaweed-enriched media publication-title: J. Sci. Food Agric. doi: 10.1002/jsfa.8702 contributor: fullname: Biancarosa – volume: 273 start-page: 123 year: 2001 ident: 10.1016/j.envpol.2021.117146_bib46 article-title: Cloning and characterization of a gene coding for a novel metallothionein in the Pacific Oyster Crassostrea gigas (CgMT2): a case of adaptive response to metal-induced stress? publication-title: Gene doi: 10.1016/S0378-1119(01)00577-7 contributor: fullname: Tanguy – volume: 14 year: 2019 ident: 10.1016/j.envpol.2021.117146_bib18 article-title: Reference gene selection for quantitative gene expression analysis in black soldier fly (Hermetia illucens) publication-title: PloS One doi: 10.1371/journal.pone.0221420 contributor: fullname: Gao – volume: 80 start-page: 1215 year: 2017 ident: 10.1016/j.envpol.2021.117146_bib41 article-title: Morphostructural and immunohistochemical study on the role of metallothionein in the detoxification of heavy metals in Apis mellifera L., 1758 publication-title: Microsc. Res. Tech. doi: 10.1002/jemt.22919 contributor: fullname: Salvaggio – volume: 361 start-page: 140 year: 2005 ident: 10.1016/j.envpol.2021.117146_bib37 article-title: Cloning, tissue expression and metal inducibility of an ubiquitous metallothionein 11EMBL accession no. MTPA AJ414050. from Panulirus argus publication-title: Gene doi: 10.1016/j.gene.2005.07.026 contributor: fullname: Moltó – volume: 11 start-page: 13 year: 2016 ident: 10.1016/j.envpol.2021.117146_bib49 article-title: Uptake of cadmium, lead and arsenic by Tenebrio molitor and Hermetia illucens from contaminated substrates publication-title: PloS One doi: 10.1371/journal.pone.0166186 contributor: fullname: van der Fels-Klerx – volume: 230 start-page: 974 year: 2019 ident: 10.1016/j.envpol.2021.117146_bib19 article-title: Bioconversion performance and life table of black soldier fly (Hermetia illucens) on fermented maize straw publication-title: J. Clean. Prod. doi: 10.1016/j.jclepro.2019.05.074 contributor: fullname: Gao – volume: 8 start-page: 1373 year: 2017 ident: 10.1016/j.envpol.2021.117146_bib26 article-title: Toxicity of cadmium and its health risks from leafy vegetable consumption publication-title: Food Funct. doi: 10.1039/C6FO01580H contributor: fullname: Huang – volume: 4 start-page: 739 year: 2012 ident: 10.1016/j.envpol.2021.117146_bib3 article-title: Mammalian metallothioneins: properties and functions publication-title: Metallomics doi: 10.1039/c2mt20081c contributor: fullname: Babula – volume: 162 start-page: 424 year: 2013 ident: 10.1016/j.envpol.2021.117146_bib22 article-title: A transcriptomic network underlies microstructural and physiological responses to cadmium in Populus x canescens publication-title: Plant Physiol. doi: 10.1104/pp.113.215681 contributor: fullname: He – volume: 1 start-page: 261 year: 2015 ident: 10.1016/j.envpol.2021.117146_bib10 article-title: Bioaccumulation of heavy metals in the black soldier fly, Hermetia illucens and effects on its life cycle publication-title: J. Insects Food Feed doi: 10.3920/JIFF2015.0030 contributor: fullname: Diener – volume: 10 year: 2015 ident: 10.1016/j.envpol.2021.117146_bib43 article-title: Identification of Glutathione S-Transferase (GST) genes from a dark septate endophytic fungus (Exophiala pisciphila) and their expression patterns under varied metals stress publication-title: PloS One contributor: fullname: Shen – volume: 388 start-page: 237 year: 1997 ident: 10.1016/j.envpol.2021.117146_bib9 article-title: Metallothionein in snail Cd and Cu metabolism publication-title: Nature doi: 10.1038/40785 contributor: fullname: Dallinger – volume: 3 year: 2014 ident: 10.1016/j.envpol.2021.117146_bib47 article-title: Microbiota from Litopenaeus vannamei: digestive tract microbial community of Pacific white shrimp (Litopenaeus vannamei) publication-title: SpringerPlus doi: 10.1186/2193-1801-3-280 contributor: fullname: Tzuc – volume: 37 start-page: 889 year: 2017 ident: 10.1016/j.envpol.2021.117146_bib20 article-title: Structural and functional alterations in Malpighian tubules as biomarkers of environmental pollution: synopsis and prospective publication-title: J. Appl. Toxicol. doi: 10.1002/jat.3454 contributor: fullname: Giglio – volume: 26 start-page: 2286 year: 2006 ident: 10.1016/j.envpol.2021.117146_bib13 article-title: A family knockout of all four Drosophila metallothioneins reveals a central role in copper homeostasis and detoxification publication-title: Mol. Cell Biol. doi: 10.1128/MCB.26.6.2286-2296.2006 contributor: fullname: Egli – volume: 6 start-page: 398 year: 2016 ident: 10.1016/j.envpol.2021.117146_bib36 article-title: Post-harvest management of phytoremediation technology publication-title: J. Environ. Anal. Toxicol. contributor: fullname: Mohanty – start-page: 1 year: 2019 ident: 10.1016/j.envpol.2021.117146_bib21 article-title: Phytoremediation of Cd and Pb interactive polluted soils by switchgrass (Panicum virgatum L.) publication-title: Int. J. Phytoremediation contributor: fullname: Guo – volume: 11 year: 2019 ident: 10.1016/j.envpol.2021.117146_bib35 article-title: Aflatoxin b1 conversion by black soldier fly (Hermetia illucens) larval enzyme extracts publication-title: Toxins doi: 10.3390/toxins11090532 contributor: fullname: Meijer – volume: 160 start-page: 81 year: 2011 ident: 10.1016/j.envpol.2021.117146_bib45 article-title: Identification of two metallothionein genes and their roles in stress responses of Musca domestica toward hyperthermy and cadmium tolerance publication-title: Comp. Biochem. Physiol. B Biochem. Mol. Biol. doi: 10.1016/j.cbpb.2011.06.008 contributor: fullname: Tang – volume: 10 start-page: 1549 year: 2018 ident: 10.1016/j.envpol.2021.117146_bib54 article-title: Metallothionein diversity and distribution in the tree of life: a multifunctional protein publication-title: Metallomics doi: 10.1039/C8MT00165K contributor: fullname: Ziller – volume: 165 start-page: 450 year: 2018 ident: 10.1016/j.envpol.2021.117146_bib25 article-title: Cloning, characterization and expression analysis of metallothioneins from Ipomoea aquatica and their cultivar-dependent roles in Cd accumulation and detoxification publication-title: Ecotoxicol. Environ. Saf. doi: 10.1016/j.ecoenv.2018.08.089 contributor: fullname: Huang – volume: 164 start-page: 85 year: 2017 ident: 10.1016/j.envpol.2021.117146_bib53 article-title: Determination of the protein expression profiles of Propsilocerus akamusi (Tokunaga) malpighian tubules response to cadmium stress by iTRAQ coupled LC–MS/MS publication-title: J. Proteom. doi: 10.1016/j.jprot.2017.05.017 contributor: fullname: Zheng – volume: 9 year: 2018 ident: 10.1016/j.envpol.2021.117146_bib1 article-title: Overexpression of RsMYB1 enhances anthocyanin accumulation and heavy metal stress tolerance in Transgenic Petunia publication-title: Front. Plant Sci. doi: 10.3389/fpls.2018.01388 contributor: fullname: Ai – volume: 231 start-page: 129 year: 2019 ident: 10.1016/j.envpol.2021.117146_bib30 article-title: Palatability of black soldier fly larvae in valorizing mixed waste coconut endosperm and soybean curd residue into larval lipid and protein sources publication-title: J. Environ. Manag. contributor: fullname: Lim – volume: 28 start-page: 731 year: 2019 ident: 10.1016/j.envpol.2021.117146_bib40 article-title: Identification of a metallothionein gene in honey bee Apis mellifera and its expression profile in response to Cd, Cu and Pb exposure publication-title: Mol. Ecol. doi: 10.1111/mec.14984 contributor: fullname: Purac – volume: 633 start-page: 912 year: 2018 ident: 10.1016/j.envpol.2021.117146_bib6 article-title: Hermetia illucens as a new and promising species for use in entomoremediation publication-title: Sci. Total Environ. doi: 10.1016/j.scitotenv.2018.03.252 contributor: fullname: Bulak – volume: 187 start-page: 21 year: 2015 ident: 10.1016/j.envpol.2021.117146_bib14 article-title: Transfer of heavy metals through terrestrial food webs: a review publication-title: Environ. Monit. Assess. doi: 10.1007/s10661-015-4436-3 contributor: fullname: Gall – volume: 9 start-page: 13 year: 2019 ident: 10.1016/j.envpol.2021.117146_bib44 article-title: The nutritive value of black soldier fly larvae reared on common organic waste streams in Kenya publication-title: Sci. Rep. doi: 10.1038/s41598-019-46603-z contributor: fullname: Shumo – volume: 125 start-page: 17 year: 2000 ident: 10.1016/j.envpol.2021.117146_bib23 article-title: Metallothionein-bound cadmium in the gut of the insect Orchesella cincta (Collembola) in relation to dietary cadmium exposure publication-title: Comp. Biochem. Physiol. C Pharmacol. Toxicol. Endocrinol. doi: 10.1016/S0742-8413(99)00087-0 contributor: fullname: Hensbergen – volume: 4 start-page: 435 year: 2014 ident: 10.1016/j.envpol.2021.117146_bib27 article-title: Metallothioneins, unconventional proteins from unconventional animals: a long journey from nematodes to mammals publication-title: Biomolecules doi: 10.3390/biom4020435 contributor: fullname: Isani – volume: 16 start-page: 133 year: 2005 ident: 10.1016/j.envpol.2021.117146_bib28 article-title: Phytoremediation: novel approaches to cleaning up polluted soils publication-title: Curr. Opin. Biotechnol. doi: 10.1016/j.copbio.2005.02.006 contributor: fullname: Kraemer – volume: 22 start-page: 100 year: 2003 ident: 10.1016/j.envpol.2021.117146_bib12 article-title: Knockout of 'metal-responsive transcription factor' MTF-1 in Drosophila by homologous recombination reveals its central role in heavy metal homeostasis publication-title: EMBO J. doi: 10.1093/emboj/cdg012 contributor: fullname: Egli – volume: 17 start-page: 1483 year: 2016 ident: 10.1016/j.envpol.2021.117146_bib31 article-title: Mammalian metallothionein-2a and oxidative stress publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms17091483 contributor: fullname: Ling – volume: 29 start-page: 2588 year: 2013 ident: 10.1016/j.envpol.2021.117146_bib52 article-title: Protein-ligand binding site recognition using complementary binding-specific substructure comparison and sequence profile alignment publication-title: Bioinformatics doi: 10.1093/bioinformatics/btt447 contributor: fullname: Yang – volume: 128 start-page: 373 year: 2004 ident: 10.1016/j.envpol.2021.117146_bib42 article-title: Phytoextraction crop disposal—an unsolved problem publication-title: Environ. Pollut. doi: 10.1016/j.envpol.2003.09.012 contributor: fullname: Sas-Nowosielska – volume: 167 start-page: 1 year: 2017 ident: 10.1016/j.envpol.2021.117146_bib55 article-title: Metagenomics analysis reveals a new metallothionein family: sequence and metal-binding features of new environmental cysteine-rich proteins publication-title: J. Inorg. Biochem. doi: 10.1016/j.jinorgbio.2016.11.017 contributor: fullname: Ziller – volume: 467 start-page: 189 year: 2000 ident: 10.1016/j.envpol.2021.117146_bib48 article-title: Drosophila MTN: a metazoan copper-thionein related to fungal forms publication-title: FEBS Lett. doi: 10.1016/S0014-5793(00)01149-2 contributor: fullname: Valls |
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