Vertex model instabilities for tissues subject to cellular activity or applied stresses

• Published in: Physical review. E Vol. 102; no. 5-1; p. 052604
• Main Authors: Pérez-Verdugo, Fernanda, Joanny, Jean-Francois, Soto, Rodrigo
• Format: Journal Article
• Language: English
• Published: United States 01.11.2020
• Subjects: Biomechanical Phenomena; Computer Simulation; Models, Biological; Stress, Mechanical

The vertex model is widely used to describe the dynamics of epithelial tissues, because of its simplicity and versatility and the direct inclusion of biophysical parameters. Here, it is shown that quite generally, when cells modify their equilibrium perimeter due to their activity, or the tissue is...