DEM modelling of breakage behaviour of semi-brittle agglomerates subject to compaction and impaction

• Published in: Powder technology Vol. 408; p. 117710
• Main Authors: Li, L.J., Zhu, Q.X., Gou, D.Z., Chan, H.-K., Kourmatzis, A., Zhao, G.T., Yang, R.Y.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.08.2022
• Subjects: Breakage; brittleness; Coarse grain; Discrete element method; drugs; energy; humidity; Semi-brittle agglomerates; Solid bonds; technology; temperature; van der Waals forces; Semi-brittle agglomerates; Solid bonds; Discrete element method; Breakage; Coarse grain

Drug powder in API-only dry powder inhalers (DPIs) is prepared in a form of agglomerates for easy handling and transport. Agglomerates tend to recrystallize due to temperature variation or being stored in a high humidity environment, causing the formation of solid bonds between particles which makes...