Optimisation of Itraconazole Therapy Using Target Drug Concentrations

• Published in: Clinical pharmacokinetics Vol. 35; no. 6; pp. 461 - 473
• Main Authors: Poirier, Marie, Cheymol, Georges
• Format: Journal Article
• Language: English
• Published: Auckland Adis international 01.12.1998
• Subjects: Antibiotics. Antiinfectious agents. Antiparasitic agents; Antifungal agents; Antifungal Agents - pharmacokinetics; Antifungal Agents - pharmacology; Antifungal Agents - therapeutic use; Biological and medical sciences; Drug Interactions; Drug Monitoring - methods; Food-Drug Interactions; Humans; Itraconazole - pharmacokinetics; Itraconazole - pharmacology; Itraconazole - therapeutic use; Medical sciences; Organ Specificity; Pharmacology. Drug treatments; Human; Drug combination; Intravenous administration; Healthy subject; Disease; Oral administration; Review; Food drug interaction; Antifungal agent; Intraindividual comparison; Activity concentration relation; Interindividual comparison; Triazole derivatives; Drug interaction; Pharmacokinetics; Itraconazole

Itraconazole is a new triazole compound with a broad spectrum of activity against a number of fungal pathogens, including Aspergillus species. The drug is being used increasingly as prophylaxis in patients with immunodepression. Itraconazole is highly lipophilic and only ionised at low pH. The absol...