Stochastic Dynamics of Nanoparticle and Virus Uptake

• Published in: Physical review letters Vol. 122; no. 8; p. 088102
• Main Authors: Frey, Felix, Ziebert, Falko, Schwarz, Ulrich S
• Format: Journal Article
• Language: English
• Published: United States 01.03.2019
• Subjects: Models, Biological; Nanoparticles - chemistry; Nanoparticles - metabolism; Stochastic Processes; Virus Internalization; Viruses - chemistry; Viruses - metabolism

The cellular uptake of nanoparticles or viruses requires that the gain of adhesion energy overcomes the cost of plasma membrane bending. It is well known that this leads to a minimal particle size for uptake. Using a simple deterministic theory for this process, we first show that, for the same radi...