Clinical Characterization of [ 18 F]T-008, a Cholesterol 24-Hydroxylase PET Ligand: Dosimetry, Kinetic Modeling, Variability, and Soticlestat Occupancy - Constantinescu, Cristian C.; Brown, Terry; Wang, Shining; Yin, Wei; Barret, Olivier; Jennings, Danna; Tauscher, Johannes (Journal of Nuclear Medicine, 2023)
Keywords: Brain; Cholesterol; Cholesterol 24-Hydroxylase; Dosimeters; Dosimetry; Female; Fluorine isotopes; Humans; Ligands; Male; Modelling; Neuroimaging; Pharmacokinetics; Positron emission; Positron emission tomography; Positron-Emission Tomography - methods; Radioactive tracers; Radiometry; Seizures; cholesterol 24-hydroxylase; dose occupancy; developmental and epileptic encephalopathy; PET imaging; soticlestat