Manganese, selenium and other trace elements in spinal cord, liver and bone in motor neurone disease

Trace element levels were measured by neutron activation analysis in spinal cord, liver and bone of 7 control patients dying of non-neurological disease and 15 patients dying of motor neurone disease (MND). The concentration of selenium was significantly elevated in the cervical cord, liver and bone...

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Bibliographic Details
Published inEuropean neurology Vol. 31; no. 1; p. 7
Main Authors Mitchell, J D, East, B W, Harris, I A, Pentland, B
Format Journal Article
LanguageEnglish
Published Switzerland 1991
Subjects
Adult
Aged
Aged, 80 and over
Bone and Bones - chemistry
Female
Humans
Liver - chemistry
Male
Manganese - analysis
Middle Aged
Motor Neurons
Neuromuscular Diseases - metabolism
Neutron Activation Analysis
Selenium - analysis
Spinal Cord - chemistry
Trace Elements - analysis
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Summary:Trace element levels were measured by neutron activation analysis in spinal cord, liver and bone of 7 control patients dying of non-neurological disease and 15 patients dying of motor neurone disease (MND). The concentration of selenium was significantly elevated in the cervical cord, liver and bone in the MND group. Although spinal cord manganese levels were increased at both the cervical and thoracic levels, the hepatic concentration was reduced in the MND patients. These findings are discussed in relation to current understanding of the pathogenesis of MND.
ISSN:0014-3022
DOI:10.1159/000116626