A prospective randomized trial of continuous infusion 5-fluorouracil (5-FU) versus 5-FU plus cisplatin in patients with advanced colorectal cancer. A trial of the Spanish Cooperative Group for Digestive Tract Tumor Therapy (T.T.D.)

• Published in: American journal of clinical oncology Vol. 15; no. 1; p. 56
• Main Authors: Díaz-Rubio, E, Jimeno, J, Antón, A, Aranda, E, Sánchez, J, Massuti, B, Cruz-Hernández, J, Carrato, A, Martin, M, Belón, J
• Format: Journal Article
• Language: English
• Published: United States 01.02.1992
• Subjects: Adenocarcinoma - drug therapy; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols - adverse effects; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Cisplatin - administration & dosage; Colorectal Neoplasms - drug therapy; Fluorouracil - administration & dosage; Fluorouracil - therapeutic use; Humans; Infusions, Intravenous; Middle Aged; Prospective Studies; Remission Induction

One hundred sixty consecutive patients with histologically confirmed colorectal cancer (advanced disease) without prior chemotherapy were entered in a randomized trial comparing 5-fluorouracil (5-FU) 1,000 mg/m2 intravenously per day for 5 consecutive days in continuous infusion versus cisplatin (CP...