CircCDK14 ameliorates interleukin-1β-induced chondrocyte damage by the miR-1183/KLF5 pathway in osteoarthritis

• Published in: Autoimmunity (Chur, Switzerland) Vol. 55; no. 6; pp. 408 - 417
• Main Authors: Lai, Xiaowei, Song, Yali, Tian, Jimei
• Format: Journal Article
• Language: English
• Published: Taylor & Francis 18.08.2022; Taylor & Francis Group
• Subjects: circCDK14; exosomes; KLF5; miR-1183

The pathogenesis of osteoarthritis (OA), an endemic and debilitating disease, remains unclear. The study aimed to reveal the role of circular RNA cyclin dependent kinase 14 (circCDK14) in OA development and the underlying mechanism. Human chondrocytes were stimulated by 10 ng/mL interleukin-1β (IL-1...