A2A R mediated modulation in IP3 levels altering the [Ca2+]i through cAMP-dependent PKA signalling pathway

• Published in: Biochimica et biophysica acta. General subjects Vol. 1866; no. 12; p. 130242
• Main Authors: Barodia, Sandeep Kumar, Sophronea, Tuithung, Luthra, Pratibha Mehta
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.12.2022
• Subjects: Adenosine A2A R; adenylate cyclase; agonists; Ca 2+ signalling; caffeine; calcium; cAMP; cAMP-dependent PKA; colorimetry; enzyme immunoassays; Forskolin; IP3; Neomycin; neurodegenerative diseases; pertussis toxin; phosphorylation; therapeutics; cAMP-dependent PKA; PLC; Adenosine A2A R; ALS; CICR; cAMP; Epac; Ca 2+ signalling; Na+/Ca2+ exchanger; CREB; TRP; PTX; CNGCs; NMDA; AC; AD; [Ca2+]i; PKA; DAG; IP3; HEK; HEK 293-A2A R; NECA; PD; Forskolin; Neomycin; ROS; GPCR; ZM241385; HD; PIP2

Stimulation of A2A receptors (A2A R) coupled to Gs/olf protein activates Adenylyl cyclase (AC) leading to the release of cAMP which activates the cAMP-dependent PKA phosphorylation. The possible role of A2A R in the modulation of free cytosolic Ca2+ concentration ([Ca2+]i) involving IP3, cAMP and PK...