Selenium regulates transcription factor NF-κB activation during the acute phase reaction

• Published in: Clinica chimica acta Vol. 334; no. 1; pp. 163 - 171
• Main Authors: Maehira, Fusako, Miyagi, Ikuko, Eguchi, Yukinori
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier B.V 01.08.2003; Elsevier
• Subjects: Acute phase response; Biological and medical sciences; C-reactive protein; Fundamental and applied biological sciences. Psychology; Hepatocytes; Inflammation; Molecular and cellular biology; NF-κB activation; Selenium; NF-κB activation; C-reactive protein; Selenium; Hepatocytes; Acute phase response; Human; Signal transduction; Acute phase protein; Regulation(control); Hepatocyte; Inflammation; Transcription factor NFκB; Transcription factor

Background: We reported a reciprocal relationship between reduced serum selenium (Se) and elevated serum C-reactive protein (CRP) in various pathological conditions in comparison with the levels in 141 healthy subjects. To clarify the implications of these observations, the effect of Se on nuclear f...