The TNF-β Gene Nco I Polymorphism Is Not Associated with Hypertriglyceridemia or Insulin Resistance in Lean and Obese Subjects

• Published in: Biochemical and biophysical research communications Vol. 236; no. 3; pp. 829 - 832
• Main Authors: Fernandez-Real, J.M., Gutierrez, C., Ricant, W., Casamitjana, R.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 30.07.1997
• Subjects: Adult; Body Composition; Body Constitution; Body Mass Index; Deoxyribonucleases, Type II Site-Specific; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - genetics; Electric Impedance; Female; Heterozygote; Homozygote; Humans; Hypertriglyceridemia - genetics; Insulin Resistance - genetics; Lymphotoxin-alpha - genetics; Male; Middle Aged; Obesity - genetics; Polymorphism, Restriction Fragment Length

Interindividual differences in TNF-α monocyte responses can be accounted for by genetic polymorphisms at the TNF-β locus defined by theNco Irestriction enzyme. Higher triglyceride levels in non-insulin-dependent diabetic patients homozygous at the 10.5-kb fragment of the TNF-β gene have been describ...