Development of a new fluorescence ratiometric switch for endogenous hypochlorite detection in monocytes of diabetic subjects by dye release method

• Published in: Tetrahedron letters Vol. 59; no. 12; pp. 1130 - 1135
• Main Authors: Das, Sangita, Aich, Krishnendu, Patra, Lakshman, Ghoshal, Kakali, Gharami, Saswati, Bhattacharyya, Maitree, Mondal, Tapan Kumar
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 21.03.2018; Elsevier
• Subjects: cardiovascular diseases; Cell-imaging; chemical reactions; chemical structure; Chemistry; Chemistry, Organic; Chemodosimeter; Colorimetric; fluorescence; fluorescent dyes; health hazards; humans; hyperlipidemia; Hypochlorite sensing; monocytes; noninsulin-dependent diabetes mellitus; organic compounds; oxidative stress; Physical Sciences; Ratiometric; Science & Technology; Hypochlorite sensing; Cell-imaging; Chemodosimeter; Ratiometric; Colorimetric; MYELOPEROXIDASE; REACTIVE OXYGEN; ACID; OXIDANT; HUMAN BLOOD-CELLS; PROBE; LIVING CELLS

A new quinoline-diaminomaleonitrile based probe was synthesised for the selective and ratiometric endogenous screening of OCl− in living diabetic blood cells. [Display omitted] •A new quinoline based probe has been designed for selective detection of OCl−.•The probe (HQMN) can detect OC− with a fast...