Associations Between TGFA/TGFB3/MSX1 Gene Polymorphisms and Congenital Non-Syndromic Hearing Impairment in a Chinese Population

• Published in: Medical science monitor Vol. 22; pp. 2253 - 2266
• Main Authors: Du, Jihong, Deng, Jianhua
• Format: Journal Article
• Language: English
• Published: United States International Scientific Literature, Inc 29.06.2016
• Subjects: Adolescent; Alleles; Asian Continental Ancestry Group - genetics; Case-Control Studies; Child; China; Clinical Research; Female; Gene Frequency; Genetic Predisposition to Disease; Genetic Variation; Hearing Loss - genetics; Humans; Linkage Disequilibrium; Male; MSX1 Transcription Factor - genetics; MSX1 Transcription Factor - metabolism; Polymorphism, Single Nucleotide; Transforming Growth Factor alpha - genetics; Transforming Growth Factor alpha - metabolism; Transforming Growth Factor beta3 - genetics; Transforming Growth Factor beta3 - metabolism

BACKGROUND The aim of this study was to investigate whether the TGFA/TGFB3/MSX1 gene polymorphisms and haplotypes lead to individual differences between congenital non-syndromic hearing impairment (NSHI) patients and normal people in a Chinese population and to analyze the risk factors for NSHI. MAT...