Dissociation of Heat Shock Proteins Expression with Ischemic Tolerance by Whole Body Hyperthermia in Rat Heart

• Published in: Journal of molecular and cellular cardiology Vol. 30; no. 6; pp. 1163 - 1172
• Main Authors: Qian, Yong-Zhen, Shipley, Joshua B., Levasseur, Joseph E., Kukreja, Rakesh C.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.1998
• Subjects: Animals; Heat shock proteins; Heat-Shock Proteins - metabolism; Heat-Shock Response; Hemodynamics; Hyperthermia; Hyperthermia, Induced - adverse effects; Infarction; Ischemia; Male; Myocardial Infarction - metabolism; Myocardial Infarction - pathology; Myocardial Ischemia - metabolism; Myocardial Reperfusion; Myocardium - metabolism; Myocardium - pathology; Rats; Rats, Sprague-Dawley; Time Factors; Heat shock proteins; Infarction; Ischemia; Hyperthermia

Heat shock (HS) results in the expression of heat shock proteins (hsp) and confers tolerance against subsequent ischemic injury. We examined the extent of myocardial protectionin vivo, and determined the level of hsp expression induced by HS as a function of time. Anesthetized rats were subjected to...