ENANTIOSELECTIVE TOTAL SYNTHESIS OF (-)-SCABRONINE D

• Published in: Heterocycles Vol. 89; no. 3; pp. 669 - 677
• Main Authors: Kobayakawa, Yu, Nakada, Masahisa
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier 2014
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; SYSTEM; CYATHANE DITERPENES; MUSHROOM; ESTERS; CYATHINS; (+/-)-ALLOCYATHIN B-2; SCABRONINE; SECRETION; NERVE GROWTH-FACTOR; SKELETON

The first enantioselective total synthesis of (-)-scabronine D comprising a unique bridged hemiacetal is described. The total synthesis is successfully accomplished using an enantiopure intermediate prepared in the total synthesis of (-)-scabronines G and A, and (-)-episcabronine A. Because the adva...